2019
Excisional Curettage of Benign Cystic Lesions.
Ibe IK, Alder KD, Henderson SE, Yu KE, Lee FY. Excisional Curettage of Benign Cystic Lesions. JBJS Essential Surgical Techniques 2019, 9: e24. PMID: 32021719, PMCID: PMC6948994, DOI: 10.2106/jbjs.st.18.00036.Peer-Reviewed Original ResearchBenign cystic lesionsAneurysmal bone cystCystic lesionsBone cystExcisional curettageWide resectionFeeding vesselsTreatment modalitiesInitial incisionUnicameral bone cystsLow recurrence rateRate of recurrenceGiant cell tumorCareful preoperative planningHigh-speed burrAdjuvant therapyThorough curettageSurgical treatmentTotal resectionRecurrence rateCortical windowCell tumorsCystic contentsNonossifying fibromaCurettageBisphosphonate-loaded Bone Cement as a Local Adjuvant Therapy for Giant Cell Tumor of Bone
Greenberg DD, Lee FY. Bisphosphonate-loaded Bone Cement as a Local Adjuvant Therapy for Giant Cell Tumor of Bone. American Journal Of Clinical Oncology 2019, 42: 231-237. PMID: 30811352, DOI: 10.1097/coc.0000000000000504.Peer-Reviewed Original ResearchConceptsGiant cell tumorAdjuvant therapyLocal adjuvant therapySystemic side effectsAvascular necrosisCell tumorsSide effectsMusculoskeletal Tumor Society scoreOsteoclast-like giant cellsAggressive bone resorptionTherapeutic Level IVHigh-speed burringLocal recurrence rateAtypical femur fracturesLevel of evidenceTraditional adjuvant therapyBone cementAtypical fracturesSystemic bisphosphonatesPulmonary metastasesSociety ScoreCurettage proceduresRecurrence rateFemur fracturesPolymethylmethacrylate bone cement
2014
Systemic Therapy in Patients with Resectable and Unresectable Cases of Giant Cell Tumor: A Systematic Review
Kaiser P, Compton J, Caldwell J, Hickernell T, Lee F. Systemic Therapy in Patients with Resectable and Unresectable Cases of Giant Cell Tumor: A Systematic Review. Journal Of Cancer Therapy 2014, 2014: 339-353. DOI: 10.4236/jct.2014.54041.Peer-Reviewed Original ResearchGiant cell tumorAnti-osteoclastic agentsSystemic bisphosphonatesSystemic treatmentResectable tumorsUnresectable casesRecurrence rateCell tumorsSide effectsCases of GCTMetastatic giant cell tumorUnresectable giant cell tumorPrimary giant cell tumorSevere side effect profileStabilization of diseaseOverall recurrence rateRetrospective case seriesSide effect profileSubset of patientsHigh-level evidenceSeries of patientsLow recurrence ratePrimary bone tumorsStandard of careCommon benign tumor
2004
Bisphosphonates May Reduce Recurrence in Giant Cell Tumor by Inducing Apoptosis
Chang SS, Suratwala SJ, Jung KM, Doppelt JD, Zhang HZ, Blaine TA, Kim TW, Winchester RJ, Lee FY. Bisphosphonates May Reduce Recurrence in Giant Cell Tumor by Inducing Apoptosis. Clinical Orthopaedics And Related Research® 2004, 426: 103-109. PMID: 15346059, DOI: 10.1097/01.blo.0000141372.54456.80.Peer-Reviewed Original ResearchConceptsGiant cell tumorCell tumorsAdjuvant therapyGiant cellsExogenous receptor activatorSpecific adjuvant therapyExtensive bone destructionTumor culturesLocal adjuvant therapyHigh recurrence rateNovel adjuvant therapyOsteoclastlike giant cellsNovel therapeutic agentsNF-kappaB ligandDose-dependent mannerBone destructionRecurrence rateAggressive tumorsBone resorptionSystemic useReceptor activatorAutocrine loopAutocrine mannerTumorsAutocrine regulation
2000
Chondroblastoma of bone.
Ramappa AJ, Lee FY, Tang P, Carlson JR, Gebhardt MC, Mankin HJ. Chondroblastoma of bone. Journal Of Bone And Joint Surgery 2000, 82: 1140-5. PMID: 10954104, DOI: 10.2106/00004623-200008000-00011.Peer-Reviewed Original ResearchConceptsChondroblastoma of boneMetastatic lesionsPrincipal presenting symptomExcellent functional resultsAggressive tumor behaviorProximal partLimitation of movementAutograft bone chipsGroup of surgeonsPresenting symptomAggressive treatmentIntralesional curettageLocal recurrenceRecurrent tumorsWidespread metastasesHistological findingsRecurrence rateSecond recurrenceThird recurrenceRare lesionsFunctional resultsTumor behaviorPatientsLarge seriesAdjacent joints