2015
Genomic landscape of cutaneous T cell lymphoma
Choi J, Goh G, Walradt T, Hong BS, Bunick CG, Chen K, Bjornson RD, Maman Y, Wang T, Tordoff J, Carlson K, Overton JD, Liu KJ, Lewis JM, Devine L, Barbarotta L, Foss FM, Subtil A, Vonderheid EC, Edelson RL, Schatz DG, Boggon TJ, Girardi M, Lifton RP. Genomic landscape of cutaneous T cell lymphoma. Nature Genetics 2015, 47: 1011-1019. PMID: 26192916, PMCID: PMC4552614, DOI: 10.1038/ng.3356.Peer-Reviewed Original Research
2002
Immunomodulatory effects of RXR rexinoids: modulation of high-affinity IL-2R expression enhances susceptibility to denileukin diftitox
Gorgun G, Foss F. Immunomodulatory effects of RXR rexinoids: modulation of high-affinity IL-2R expression enhances susceptibility to denileukin diftitox. Blood 2002, 100: 1399-1403. PMID: 12149223, DOI: 10.1182/blood-2002-01-0300.Peer-Reviewed Original ResearchMeSH KeywordsAdjuvants, ImmunologicAlitretinoinAntineoplastic AgentsBexaroteneB-LymphocytesDiphtheria ToxinGene Expression RegulationHumansInterleukin-2Leukemia, Lymphocytic, Chronic, B-CellLeukemia-Lymphoma, Adult T-CellPrecursor B-Cell Lymphoblastic Leukemia-LymphomaReceptors, Interleukin-2Receptors, Retinoic AcidRecombinant Fusion ProteinsRetinoid X ReceptorsRetinoidsTetrahydronaphthalenesT-LymphocytesTranscription FactorsTretinoinTumor Cells, CulturedConceptsRetinoic acid receptorsImmunomodulatory effectsIL-2RHigh affinity IL-2R expressionCutaneous T-cell lymphomaHigh affinity IL-2R.Interleukin-2 receptor expressionIL-2R expressionT-cell lymphomaB cell leukemia cellsB-cell leukemiaT-cell leukemiaMechanism of actionAutoimmune diseasesHematologic malignanciesClinical activityReceptor expressionLymphoid malignanciesIL-2R.Retinoid X receptor (RXR) familyP75 subunitAcid receptorsRexinoid receptorsLeukemia cellsRexinoidsInterleukin-7 receptor expression and activation in nonhaematopoietic neoplastic cell lines
Cosenza L, Gorgun G, Urbano A, Foss F. Interleukin-7 receptor expression and activation in nonhaematopoietic neoplastic cell lines. Cellular Signalling 2002, 14: 317-325. PMID: 11858939, DOI: 10.1016/s0898-6568(01)00245-5.Peer-Reviewed Original ResearchMeSH KeywordsBrain NeoplasmsCell LineEpithelial CellsHematopoietic Stem CellsHumansImmunoblottingInterleukin Receptor Common gamma SubunitJanus Kinase 3Lung NeoplasmsNeoplasmsNuclease Protection AssaysProtein-Tyrosine KinasesProto-Oncogene ProteinsProto-Oncogene Proteins c-fynReceptors, Interleukin-7RNA, MessengerSignal TransductionTissue DistributionTranscription, GeneticTumor Cells, CulturedConceptsIL-7R mRNABrain tumor cell linesIL-7RIL-7RalphaCell linesTumor cell linesInterleukin-7 receptor expressionReceptor-directed therapyNational Cancer Institute tumor panelBreast cancer cell linesReceptor gamma chainLung cancer cellsInterleukin-2 receptor gamma chainHeterodimeric complex consistingS1 nuclease protection assaysCellular differentiation processesEpithelial tumor cellsCancer cell linesNuclease protection assaysS1 nuclease protectionLung cancerSerine residue phosphorylationReceptor expressionNeoplastic cell linesInterleukin-7Mechanisms of apoptosis by the tyrphostin AG957 in hematopoietic cells
Urbano A, Gorgun G, Foss F. Mechanisms of apoptosis by the tyrphostin AG957 in hematopoietic cells. Biochemical Pharmacology 2002, 63: 689-692. PMID: 11992636, DOI: 10.1016/s0006-2952(01)00916-9.Peer-Reviewed Original ResearchConceptsCytochrome c/ApafPhosphatidylinositol-3-kinase/AktHematopoietic cellsTyrphostin tyrosine kinase inhibitorKinase/AktChronic myelogenous leukemia blastsMechanism of apoptosisCell line NALM-6BAD complexLeukemia cellsPhosphorylation stateC-CblAdaptor moleculeGrowth arrestAltered phosphorylationChronic myelogenous leukemia cellsMyelogenous leukemia cellsProgenitor cellsApoptosisTyrphostin AG957AG957NALM-6Kinase inhibitorsGrowth inhibitionAkt