2024
Repetitive Mild Closed-Head Injury Induced Synapse Loss and Increased Local BOLD-fMRI Signal Homogeneity
Markicevic M, Mandino F, Toyonaga T, Cai Z, Fesharaki-Zadeh A, Shen X, Strittmatter S, Lake E. Repetitive Mild Closed-Head Injury Induced Synapse Loss and Increased Local BOLD-fMRI Signal Homogeneity. Journal Of Neurotrauma 2024 PMID: 39096127, DOI: 10.1089/neu.2024.0095.Peer-Reviewed Original ResearchChronic variable stressRegional homogeneityFunctional brain abnormalitiesSynapse densityMild closed-head injuryClosed-head injuryTraumatic brain injuryTreat traumatic brain injuryNeurobiological alterationsMild head injuryVariable stressBrain abnormalitiesPositron emission tomographyMultimodal studiesSynaptic densityMagnetic resonance imagingBrain imagingBrain injuryInduce synapse lossFMRIInjured miceMouse modelEmission tomographyResonance imagingCompensatory mechanisms
2021
Lipocalin‐Type Prostaglandin d Synthase Conjugates as Magnetic Resonance Imaging Contrast Agents for Detecting Amyloid β‐Rich Regions in the Brain of Live Alzheimer's Disease Mice
Sharma B, Grandjean J, Phillips M, Kumar A, Mandino F, Yeow L, Low K, Nandwana V, Dravid V, Bengang X, Lim S, Pervushin K. Lipocalin‐Type Prostaglandin d Synthase Conjugates as Magnetic Resonance Imaging Contrast Agents for Detecting Amyloid β‐Rich Regions in the Brain of Live Alzheimer's Disease Mice. Advanced NanoBiomed Research 2021, 1 DOI: 10.1002/anbr.202100019.Peer-Reviewed Original ResearchMagnetic resonance imagingAlzheimer's diseaseDisease miceNon-invasive intranasal administrationEarly detectionAlzheimer's disease micePotential neuroprotective functionQuality of lifeContrast-enhanced visualizationLipocalin-type prostaglandin D synthaseBrain amyloidIntranasal administrationNeuroprotective functionDetection of amyloidProstaglandin D synthaseCerebrospinal fluidAmyloid β-peptideL-PGDSCurrent diagnosisMouse brainResonance imagingBrain regionsLow success rateNeuronal cellsSuccess rate
2020
Animal Functional Magnetic Resonance Imaging: Trends and Path Toward Standardization
Mandino F, Cerri D, Garin C, Straathof M, van Tilborg G, Chakravarty M, Dhenain M, Dijkhuizen R, Gozzi A, Hess A, Keilholz S, Lerch J, Shih Y, Grandjean J. Animal Functional Magnetic Resonance Imaging: Trends and Path Toward Standardization. Frontiers In Neuroinformatics 2020, 13: 78. PMID: 32038217, PMCID: PMC6987455, DOI: 10.3389/fninf.2019.00078.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingWhole-brain functional magnetic resonance imagingResting-state fMRI connectivityMagnetic resonance imagingAnimal fMRI studiesNeuromodulatory toolNeuronal activityNon-invasive windowResonance imagingStudy designFMRI connectivityNeuroimaging protocolGold standardLack of standardizationFMRI studyBrain activityEvidence-based scienceReplication studyPast yearFMRI communityBrain