Fengshan Liang, PhD
Research Scientist In Laboratory MedicineDownloadHi-Res Photo
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Laboratory Medicine
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Research Scientist In Laboratory Medicine
Appointments
Laboratory Medicine
Research ScientistPrimary
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Education & Training
- PhD
- Chinese Academy of Sciences (2004)
Research
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Overview
Medical Research Interests
Chemicals and Drugs; Diseases; Health Care
ORCID
0009-0007-9551-9508
Research at a Glance
Yale Co-Authors
Frequent collaborators of Fengshan Liang's published research.
Publications Timeline
A big-picture view of Fengshan Liang's research output by year.
Sandy Chang, MD, PhD, BS
Abhishek Gupta
Former YSMManoj M Pillai, MBBS, MD
Peili Gu, PhD
Prajwal Boddu, MD, PhD
Rekha Rai, PhD
21Publications
1,003Citations
Publications
2026
TRF2–RAP1 inhibits homology-directed repair of telomeres by promoting BLM-mediated removal of telomere R-loops
Liang F, Chang S. TRF2–RAP1 inhibits homology-directed repair of telomeres by promoting BLM-mediated removal of telomere R-loops. Nucleic Acids Research 2026, 54: gkag272. PMID: 41914496, PMCID: PMC13036488, DOI: 10.1093/nar/gkag272.Peer-Reviewed Original ResearchCitationsAltmetric
2024
TRF2–RAP1 represses RAD51-dependent homology-directed telomere repair by promoting BLM-mediated D-loop unwinding and inhibiting BLM–DNA2-dependent 5′-end resection
Liang F, Rai R, Sodeinde T, Chang S. TRF2–RAP1 represses RAD51-dependent homology-directed telomere repair by promoting BLM-mediated D-loop unwinding and inhibiting BLM–DNA2-dependent 5′-end resection. Nucleic Acids Research 2024, 52: 9695-9709. PMID: 39082275, PMCID: PMC11381343, DOI: 10.1093/nar/gkae642.Peer-Reviewed Original ResearchCitationsAltmetricThe FANCI/FANCD2 complex links DNA damage response to R-loop regulation through SRSF1-mediated mRNA export
Olazabal-Herrero A, He B, Kwon Y, Gupta A, Dutta A, Huang Y, Boddu P, Liang Z, Liang F, Teng Y, Lan L, Chen X, Pei H, Pillai M, Sung P, Kupfer G. The FANCI/FANCD2 complex links DNA damage response to R-loop regulation through SRSF1-mediated mRNA export. Cell Reports 2024, 43: 113610. PMID: 38165804, PMCID: PMC10865995, DOI: 10.1016/j.celrep.2023.113610.Peer-Reviewed Original ResearchCitationsAltmetric
2023
Pot1b −/− tumors activate G-quadruplex-induced DNA damage to promote telomere hyper-elongation
Takasugi T, Gu P, Liang F, Staco I, Chang S. Pot1b −/− tumors activate G-quadruplex-induced DNA damage to promote telomere hyper-elongation. Nucleic Acids Research 2023, 51: 9227-9247. PMID: 37560909, PMCID: PMC10516629, DOI: 10.1093/nar/gkad648.Peer-Reviewed Original ResearchCitationsAltmetric
2020
The DNA-binding activity of USP1-associated factor 1 is required for efficient RAD51-mediated homologous DNA pairing and homology-directed DNA repair
Liang F, Miller AS, Tang C, Maranon D, Williamson EA, Hromas R, Wiese C, Zhao W, Sung P, Kupfer GM. The DNA-binding activity of USP1-associated factor 1 is required for efficient RAD51-mediated homologous DNA pairing and homology-directed DNA repair. Journal Of Biological Chemistry 2020, 295: 8186-8194. PMID: 32350107, PMCID: PMC7294083, DOI: 10.1074/jbc.ra120.013714.Peer-Reviewed Original ResearchCitations
2019
Chromatin‐bound cGAS is an inhibitor of DNA repair and hence accelerates genome destabilization and cell death
Jiang H, Xue X, Panda S, Kawale A, Hooy RM, Liang F, Sohn J, Sung P, Gekara NO. Chromatin‐bound cGAS is an inhibitor of DNA repair and hence accelerates genome destabilization and cell death. The EMBO Journal 2019, 38: embj2019102718. PMID: 31544964, PMCID: PMC6826206, DOI: 10.15252/embj.2019102718.Peer-Reviewed Original ResearchCitationsAltmetricDNA requirement in FANCD2 deubiquitination by USP1-UAF1-RAD51AP1 in the Fanconi anemia DNA damage response
Liang F, Miller AS, Longerich S, Tang C, Maranon D, Williamson EA, Hromas R, Wiese C, Kupfer GM, Sung P. DNA requirement in FANCD2 deubiquitination by USP1-UAF1-RAD51AP1 in the Fanconi anemia DNA damage response. Nature Communications 2019, 10: 2849. PMID: 31253762, PMCID: PMC6599204, DOI: 10.1038/s41467-019-10408-5.Peer-Reviewed Original ResearchCitationsAltmetricBinding of FANCI-FANCD2 Complex to RNA and R-Loops Stimulates Robust FANCD2 Monoubiquitination
Liang Z, Liang F, Teng Y, Chen X, Liu J, Longerich S, Rao T, Green AM, Collins NB, Xiong Y, Lan L, Sung P, Kupfer GM. Binding of FANCI-FANCD2 Complex to RNA and R-Loops Stimulates Robust FANCD2 Monoubiquitination. Cell Reports 2019, 26: 564-572.e5. PMID: 30650351, PMCID: PMC6350941, DOI: 10.1016/j.celrep.2018.12.084.Peer-Reviewed Original ResearchCitationsAltmetric
2017
BRCA1–BARD1 promotes RAD51-mediated homologous DNA pairing
Zhao W, Steinfeld JB, Liang F, Chen X, Maranon DG, Jian Ma C, Kwon Y, Rao T, Wang W, Sheng C, Song X, Deng Y, Jimenez-Sainz J, Lu L, Jensen RB, Xiong Y, Kupfer GM, Wiese C, Greene EC, Sung P. BRCA1–BARD1 promotes RAD51-mediated homologous DNA pairing. Nature 2017, 550: 360-365. PMID: 28976962, PMCID: PMC5800781, DOI: 10.1038/nature24060.Peer-Reviewed Original ResearchCitationsAltmetricMeSH KeywordsAmino Acid SequenceBase PairingBRCA1 ProteinBRCA2 ProteinChromosome PairingFanconi Anemia Complementation Group N ProteinGenes, BRCA1Genes, BRCA2HumansMultiprotein ComplexesMutationProtein BindingRad51 RecombinaseRecombinational DNA RepairSequence Homology, Nucleic AcidTemplates, GeneticTumor Suppressor ProteinsUbiquitin-Protein Ligases
2016
Ubiquilin/Dsk2 promotes inclusion body formation and vacuole (lysosome)-mediated disposal of mutated huntingtin.
Chuang KH, Liang F, Higgins R, Wang Y. Ubiquilin/Dsk2 promotes inclusion body formation and vacuole (lysosome)-mediated disposal of mutated huntingtin. Molecular Biology Of The Cell 2016, 27: 2025-36. PMID: 27170182, PMCID: PMC4927277, DOI: 10.1091/mbc.E16-01-0026.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
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Activities
activity UAF1 DNA Binding Activity is Critical for RAD51-Mediated Homologous DNA Pairing.
01/01/2019 - PresentOral PresentationUAF1 DNA Binding Activity is Critical for RAD51-Mediated Homologous DNA Pairing.DetailsChicago, IL, United StatesSponsored by The 31st Annual FA Scientific Symposium.activity The Role of UAF1 in the Fanconi Anemia Pathway Regulation of Homologous Recombination-Mediated Genome Maintenance.
01/01/2016 - PresentPoster PresentationThe Role of UAF1 in the Fanconi Anemia Pathway Regulation of Homologous Recombination-Mediated Genome Maintenance.DetailsWashington, DC, United StatesSponsored by The 2016 American Society of Hematology (ASH) meeting.activity Promotion of RAD51-mediated Homologous DNA Pairing by the RAD51AP1-UAF1 Complex.
01/01/2016 - PresentPoster PresentationPromotion of RAD51-mediated Homologous DNA Pairing by the RAD51AP1-UAF1 Complex.DetailsBellevue, WA, United StatesSponsored by The 28th Annual FA Scientific Symposium.activity RAD51AP1-UAF1 Promotes RAD51-mediated Homologous DNA Pairing.
01/01/2015 - PresentPoster PresentationRAD51AP1-UAF1 Promotes RAD51-mediated Homologous DNA Pairing.DetailsFalmouth, MA, United StatesSponsored by Yale Molecular Biophysics and Biochemistry Research Meetingactivity Coordination of chromatid separation and spindle elongation by antagonistic activities of mitotic and S-phase CDKs
01/01/2012 - PresentPoster PresentationCoordination of chromatid separation and spindle elongation by antagonistic activities of mitotic and S-phase CDKsDetailsAtlanta, GA, United StatesSponsored by SERYM