2013
Candidate Sequence Variants and Fetal Hemoglobin in Children with Sickle Cell Disease Treated with Hydroxyurea
Green NS, Ender KL, Pashankar F, Driscoll C, Giardina PJ, Mullen CA, Clark LN, Manwani D, Crotty J, Kisselev S, Neville KA, Hoppe C, Barral S. Candidate Sequence Variants and Fetal Hemoglobin in Children with Sickle Cell Disease Treated with Hydroxyurea. PLOS ONE 2013, 8: e55709. PMID: 23409025, PMCID: PMC3567082, DOI: 10.1371/journal.pone.0055709.Peer-Reviewed Original ResearchConceptsSickle cell diseaseFetal hemoglobin levelsHemoglobin levelsCell diseaseFetal hemoglobinBaseline levelsAdult sickle cell diseasePediatric sickle cell diseaseSubset of childrenPharmacologic therapyHydroxyurea therapyClinical severityPediatric diseasesInduced levelsSignificant associationTherapeutic inductionCandidate single nucleotide polymorphismsDiseaseSingle nucleotide polymorphismsHemoglobinSequence variantsChildrenTherapyBaselineHydroxyurea
2012
Massive splenic infarction in an adolescent with hemoglobin S‐HPFH
Whyte D, Forget B, Chui DH, Luo H, Pashankar F. Massive splenic infarction in an adolescent with hemoglobin S‐HPFH. Pediatric Blood & Cancer 2012, 60: e49-e51. PMID: 23281181, DOI: 10.1002/pbc.24444.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnemia, Sickle CellFetal HemoglobinHemoglobin, SickleHumansMaleSplenic InfarctionConceptsMassive splenic infarctVaso-occlusive crisisBenign clinical courseMassive splenic infarctionHistory of anemiaSickle cell anemiaClinical courseClinical suspicionSevere complicationsSplenic infarctSplenic infarctionHb S mutationCell anemiaAnemiaCompound heterozygosityFetal hemoglobinComplicationsPatientsS mutationsLittle evidenceHigh levelsInfarctionInfarctsHospitalSuspicion