2024
Genome-Wide Association Study of Chronic Pain in Sickle Cell Disease
Sowa A, Hu Y, Gladwin M, Gordeuk V, Nouraie S, Zhang Y, Pashankar F, Krishnamurti L, Gruen J. Genome-Wide Association Study of Chronic Pain in Sickle Cell Disease. Blood 2024, 144: 5298. DOI: 10.1182/blood-2024-208093.Peer-Reviewed Original ResearchGenome-wide association studiesChronic painSickle cell diseaseGenome-wide association study studiesCHD2 geneGenome-wide significance thresholdAssociated with cognitive functionGenome-wide significancePatient-reported painStudy of chronic painModify chromatin structureFamily of genesSubtypes of sickle cell diseaseProportional odds logistic regressionHardy-Weinberg equilibriumChronic pain levelsCohort of individualsCell diseaseWell-phenotyped cohortAssociation of genetic polymorphismsEpisodes of acute painSickle cell disease patientsPopulation stratificationAtypical absence seizuresChromatin structure
2021
Prevalence and risk factors of cognitive impairment in children with sickle cell disease in Egypt
Youssry I, ElGhamrawy M, Seif H, Balsamo L, Pashankar F, Mahrous M, Salama N. Prevalence and risk factors of cognitive impairment in children with sickle cell disease in Egypt. International Journal Of Hematology 2021, 115: 399-405. PMID: 34792734, DOI: 10.1007/s12185-021-03260-1.Peer-Reviewed Original ResearchConceptsSickle cell diseaseHigh lactate dehydrogenaseCell diseaseCognitive impairmentRisk factorsLactate dehydrogenaseCairo University Children's HospitalOlder ageSickle cell disease patientsUniversity Children's HospitalPossible risk factorsMagnetic resonance angiographyMagnetic resonance imagingHydroxyurea therapyTranscranial DopplerChildren's HospitalDisease patientsUnivariate analysisEarly initiationPatientsResonance angiographyImpaired cognitionResonance imagingIntelligence quotient (IQ) testDisease