2020
Insulin-induced vascular redox dysregulation in human atherosclerosis is ameliorated by dipeptidyl peptidase 4 inhibition
Akoumianakis I, Badi I, Douglas G, Chuaiphichai S, Herdman L, Akawi N, Margaritis M, Antonopoulos AS, Oikonomou EK, Psarros C, Galiatsatos N, Tousoulis D, Kardos A, Sayeed R, Krasopoulos G, Petrou M, Schwahn U, Wohlfart P, Tennagels N, Channon KM, Antoniades C. Insulin-induced vascular redox dysregulation in human atherosclerosis is ameliorated by dipeptidyl peptidase 4 inhibition. Science Translational Medicine 2020, 12 PMID: 32350133, PMCID: PMC7212010, DOI: 10.1126/scitranslmed.aav8824.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAtherosclerosisCoronary Artery BypassDipeptidyl Peptidase 4HumansInsulinMiceOxidation-ReductionConceptsDipeptidyl peptidase-4 inhibitorsCoronary artery bypass surgeryAggressive insulin treatmentInsulin treatmentCoronary atherosclerosisEndothelial functionAbnormal responseHigh-fat diet-fed ApoEOral dipeptidyl peptidase-4 inhibitorLong-term combination therapyHuman internal mammary arteryDipeptidyl peptidase-4 inhibitionHigher cardiac mortalityPeptidase-4 inhibitionVascular insulin responsesVascular redox stateArtery bypass surgeryInternal mammary arteryInsulin resistance statusNitric oxide bioavailabilityPeptidase-4 inhibitorsPlasma DPP4 activityVascular oxidative stressRecent clinical trialsInsulin-sensitizing effects
2017
A prospective study of external stenting of saphenous vein grafts to the right coronary artery: the VEST II study
Taggart DP, Amin S, Djordjevic J, Oikonomou EK, Thomas S, Kampoli AM, Sabharwal N, Antoniades C, Krasopoulos G. A prospective study of external stenting of saphenous vein grafts to the right coronary artery: the VEST II study. European Journal Of Cardio-Thoracic Surgery 2017, 51: 952-958. PMID: 28379404, DOI: 10.1093/ejcts/ezw438.Peer-Reviewed Original ResearchMeSH KeywordsAgedCoronary AngiographyCoronary Artery BypassCoronary VesselsFemaleHumansMaleMiddle AgedProspective StudiesSaphenous VeinStentsVascular PatencyConceptsRight coronary arteryComputed tomography angiographyCoronary arteryExternal stentRight internal mammary artery graftInternal mammary artery graftLeft internal mammary arteryGraft 1 yearMammary artery graftsRight coronary territoryCoronary artery bypassEnd of surgeryInternal mammary arterySaphenous vein graftsSide branchesLeft territoryRight territorySVG patencyArtery bypassArtery graftExternal stentingMammary arteryPrimary endpointGraft failureII study