2023
Use of Wearable Devices in Individuals With or at Risk for Cardiovascular Disease in the US, 2019 to 2020
Dhingra L, Aminorroaya A, Oikonomou E, Nargesi A, Wilson F, Krumholz H, Khera R. Use of Wearable Devices in Individuals With or at Risk for Cardiovascular Disease in the US, 2019 to 2020. JAMA Network Open 2023, 6: e2316634. PMID: 37285157, PMCID: PMC10248745, DOI: 10.1001/jamanetworkopen.2023.16634.Peer-Reviewed Original ResearchConceptsHealth Information National Trends SurveyUS adultsExacerbate disparitiesWearable device usersCardiovascular diseaseCardiovascular healthPopulation-based cross-sectional studySelf-reported cardiovascular diseaseCardiovascular disease risk factorsNational Trends SurveyOverall US adult populationCardiovascular risk factor profileSelf-reported accessAssociated with lower useUse of wearable devicesImprove cardiovascular healthLower household incomeLower educational attainmentUS adult populationRisk factor profileNationally representative sampleCross-sectional studyProportion of adultsTrends SurveyWearable device data
2019
Adipose tissue–derived WNT5A regulates vascular redox signaling in obesity via USP17/RAC1-mediated activation of NADPH oxidases
Akoumianakis I, Sanna F, Margaritis M, Badi I, Akawi N, Herdman L, Coutinho P, Fagan H, Antonopoulos AS, Oikonomou EK, Thomas S, Chiu AP, Chuaiphichai S, Kotanidis CP, Christodoulides C, Petrou M, Krasopoulos G, Sayeed R, Lv L, Hale A, Naeimi Kararoudi M, McNeill E, Douglas G, George S, Tousoulis D, Channon KM, Antoniades C. Adipose tissue–derived WNT5A regulates vascular redox signaling in obesity via USP17/RAC1-mediated activation of NADPH oxidases. Science Translational Medicine 2019, 11 PMID: 31534019, PMCID: PMC7212031, DOI: 10.1126/scitranslmed.aav5055.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAdipose TissueAnimalsArteriesAtherosclerosisBlood VesselsCell MovementEndopeptidasesEnzyme ActivationLigandsMice, Inbred C57BLMuscle, Smooth, VascularMyocytes, Smooth MuscleNADPH OxidasesObesityOxidantsOxidation-ReductionRac1 GTP-Binding ProteinSignal TransductionVascular DiseasesWnt-5a ProteinConceptsAdipose tissueArterial wallFrizzled-related protein 5Oxidative stressArterial oxidative stressVascular disease pathogenesisNADPH oxidaseCoronary plaque progressionCoronary artery diseaseVascular oxidative stressVascular smooth muscle cellsFrizzled-2Smooth muscle cellsVascular redoxArtery diseaseHuman arterial wallPlasma concentrationsPlaque progressionParacrine mechanismsObesityParacrine effectsDisease pathogenesisMuscle cellsTranslational implicationsVascular signaling