2019
Adipose tissue–derived WNT5A regulates vascular redox signaling in obesity via USP17/RAC1-mediated activation of NADPH oxidases
Akoumianakis I, Sanna F, Margaritis M, Badi I, Akawi N, Herdman L, Coutinho P, Fagan H, Antonopoulos AS, Oikonomou EK, Thomas S, Chiu AP, Chuaiphichai S, Kotanidis CP, Christodoulides C, Petrou M, Krasopoulos G, Sayeed R, Lv L, Hale A, Naeimi Kararoudi M, McNeill E, Douglas G, George S, Tousoulis D, Channon KM, Antoniades C. Adipose tissue–derived WNT5A regulates vascular redox signaling in obesity via USP17/RAC1-mediated activation of NADPH oxidases. Science Translational Medicine 2019, 11 PMID: 31534019, PMCID: PMC7212031, DOI: 10.1126/scitranslmed.aav5055.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAdipose TissueAnimalsArteriesAtherosclerosisBlood VesselsCell MovementEndopeptidasesEnzyme ActivationLigandsMice, Inbred C57BLMuscle, Smooth, VascularMyocytes, Smooth MuscleNADPH OxidasesObesityOxidantsOxidation-ReductionRac1 GTP-Binding ProteinSignal TransductionVascular DiseasesWnt-5a ProteinConceptsAdipose tissueArterial wallFrizzled-related protein 5Oxidative stressArterial oxidative stressVascular disease pathogenesisNADPH oxidaseCoronary plaque progressionCoronary artery diseaseVascular oxidative stressVascular smooth muscle cellsFrizzled-2Smooth muscle cellsVascular redoxArtery diseaseHuman arterial wallPlasma concentrationsPlaque progressionParacrine mechanismsObesityParacrine effectsDisease pathogenesisMuscle cellsTranslational implicationsVascular signaling
2017
Predictive value of telomere length on outcome following acute myocardial infarction: evidence for contrasting effects of vascular vs. blood oxidative stress
Margaritis M, Sanna F, Lazaros G, Akoumianakis I, Patel S, Antonopoulos AS, Duke C, Herdman L, Psarros C, Oikonomou EK, Shirodaria C, Petrou M, Sayeed R, Krasopoulos G, Lee R, Tousoulis D, Channon KM, Antoniades C. Predictive value of telomere length on outcome following acute myocardial infarction: evidence for contrasting effects of vascular vs. blood oxidative stress. European Heart Journal 2017, 38: 3094-3104. PMID: 28444175, PMCID: PMC5837455, DOI: 10.1093/eurheartj/ehx177.Peer-Reviewed Original ResearchConceptsPeripheral blood mononuclear cellsAcute myocardial infarctionVascular smooth muscle cellsVascular oxidative stressSaphenous veinMyocardial infarctionOxidative stressPredictive valueRecent acute myocardial infarctionCoronary artery bypassBlood mononuclear cellsClinical predictive valueBlood oxidative stressSmooth muscle cellsFunctional genetic polymorphismsEffects of vascularTissue-specific biomarkersArtery bypassProspective cohortConsecutive patientsClinical outcomesVascular factorsPost-AMIMononuclear cellsArtery segments
2016
Inflammatory cytokines in atherosclerosis: current therapeutic approaches
Tousoulis D, Oikonomou E, Economou EK, Crea F, Kaski JC. Inflammatory cytokines in atherosclerosis: current therapeutic approaches. European Heart Journal 2016, 37: 1723-1732. PMID: 26843277, DOI: 10.1093/eurheartj/ehv759.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsChronic inflammatory diseaseCurrent therapeutic approachesPathogenesis of atherosclerosisRole of cytokinesCardiovascular disease progressionTreatment of atherosclerosisPotential clinical significanceSmooth muscle cellsInflammatory cascadeInflammatory cytokinesInflammatory diseasesDisease progressionClinical significanceTherapeutic approachesAtherosclerotic plaquesColchicine actAtherosclerosisMuscle cellsCytokinesTypes of cellsSpecific antibodiesKey moleculesMultiple effectsCellsStatins
2015
The Role and Predictive Value of Cytokines in Atherosclerosis and Coronary Artery Disease.
Tousoulis D, Economou EK, Oikonomou E, Papageorgiou N, Siasos G, Latsios G, Kokkou E, Mourouzis K, Papaioannou S, Deftereos S, Cleman MW, Lymberi M, Gennimata V, Stefanadis C. The Role and Predictive Value of Cytokines in Atherosclerosis and Coronary Artery Disease. Current Medicinal Chemistry 2015, 22: 2636-50. PMID: 25876746, DOI: 10.2174/0929867322666150415145814.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCoronary artery diseaseArtery diseaseChronic inflammatory diseasePathogenesis of atherosclerosisRole of cytokinesProcess of atherogenesisSmooth muscle cellsPrognostic significanceInflammatory diseasesAtherosclerotic plaquesPredictive valueAtherosclerosisCytokinesMuscle cellsTypes of cellsDiseaseMultiple effectsCellsCurrent informationInflammationAtherogenesisPathogenesisLeukocytesPlaques