2024
Development and multinational validation of an algorithmic strategy for high Lp(a) screening
Aminorroaya A, Dhingra L, Oikonomou E, Saadatagah S, Thangaraj P, Vasisht Shankar S, Spatz E, Khera R. Development and multinational validation of an algorithmic strategy for high Lp(a) screening. Nature Cardiovascular Research 2024, 3: 558-566. PMID: 39195936, DOI: 10.1038/s44161-024-00469-1.Peer-Reviewed Original ResearchElectronic health recordsAssociated with premature atherosclerotic cardiovascular diseaseElevated Lp(aHealth recordsUK BiobankPremature atherosclerotic cardiovascular diseaseMachine learning modelsAtherosclerotic cardiovascular diseaseCohort studyReal-world settingsTargeted screeningCardiovascular diseaseLearning modelsNovel targeted therapeuticsAlgorithmic strategiesCohortProbability thresholdScreeningClinical featuresValidation cohortElevated lipoproteinRisk inspectionARICLp(a
2016
Prognostic implications of epicardial fat volume quantification in acute pericarditis
Lazaros G, Antonopoulos AS, Oikonomou EK, Vasileiou P, Oikonomou E, Stroumpouli E, Karavidas A, Antoniades C, Tousoulis D. Prognostic implications of epicardial fat volume quantification in acute pericarditis. European Journal Of Clinical Investigation 2016, 47: 129-136. PMID: 27931089, DOI: 10.1111/eci.12711.Peer-Reviewed Original ResearchConceptsEpicardial fat volumeCardiac computerized tomographyComposite clinical endpointAcute pericarditisIncessant pericarditisChest painPrognostic implicationsClinical endpointsPoor responsePericardial effusion sizeOutcomes of patientsAtrial fibrillation developmentImportant prognostic implicationsCardiovascular disease pathogenesisAnti-inflammatory drugsLower odds ratioFifty patientsClinical featuresEffusion sizeFirst diagnosisPrognostic informationOdds ratioPericarditisFat volumePatients