2023
Cognitive impairment in long-COVID and its association with persistent dysregulation in inflammatory markers
Damiano R, de Almeida Rocca C, de Pádua Serafim A, Loftis J, Talib L, Pan P, Cunha-Neto E, Kalil J, de Castro G, Seelaender M, Guedes B, Marie S, de Souza H, Nitrini R, Miguel E, Busatto G, Forlenza O, Group H, Utiyama E, Segurado A, Perondi B, Miethke-Morais A, Montal A, Harima L, Fusco S, Silva M, Rocha M, Marcilio I, Rios I, Kawano F, de Jesus M, Kallas É, Carmo C, Tanaka C, Marchini J, Carvalho C, Ferreira J, Levin A, Oliveira M, Guimarães T, dos Santos Lázari C, da Silva Duarte A, Sabino E, Magri M, Barros-Filho T, Francisco M. Cognitive impairment in long-COVID and its association with persistent dysregulation in inflammatory markers. Frontiers In Immunology 2023, 14: 1174020. PMID: 37287969, PMCID: PMC10242059, DOI: 10.3389/fimmu.2023.1174020.Peer-Reviewed Original ResearchConceptsCognitive impairmentInflammatory markersSARS-CoV-2 infectionLong-term cognitive impairmentLong-term cognitive outcomesC-reactive proteinDisease severity markersCOVID-19 infectionCognitive performanceHospital dischargeInflammatory backgroundClinical statusD-dimerSeverity markersGeneral cognitionOverall cognitive performanceTNF-betaPhysical activityParticipants 6Severe formG-CSFPersistent dysregulationMultivariate analysisSociodemographic characteristicsCognitive deficitsSpatial normalization discrepancies between native and MNI152 brain template scans in gamma ventral capsulotomy patients
Giff A, Noren G, Magnotti J, Lopes A, Batistuzzo M, Hoexter M, Greenberg B, Marsland R, Miguel E, Rasmussen S, McLaughlin N. Spatial normalization discrepancies between native and MNI152 brain template scans in gamma ventral capsulotomy patients. Psychiatry Research Neuroimaging 2023, 329: 111595. PMID: 36680842, PMCID: PMC10153791, DOI: 10.1016/j.pscychresns.2023.111595.Peer-Reviewed Original ResearchDepression in mothers at childhood: Direct and indirect association with problematic gaming in late adolescence/young adulthood
Roza T, Rabelo-da-Ponte F, Spritzer D, Hoffmann M, Massuda R, Salum G, Miguel E, Rohde L, Pan P, Kessler F, Gadelha A, Passos I. Depression in mothers at childhood: Direct and indirect association with problematic gaming in late adolescence/young adulthood. Journal Of Psychiatric Research 2023, 159: 14-21. PMID: 36652752, DOI: 10.1016/j.jpsychires.2023.01.022.Peer-Reviewed Original ResearchConceptsAdolescence/young adulthoodMothers' depressionLate adolescence/young adulthoodRisk factorsSchool-based cohortYoung adulthoodMultiple confounding factorsLogistic regression modelsInverse probability weightsConfounding factorsExternalizing disordersInternalizing disordersDepressionPotential roleDisordersChildhoodMediatorsRegression modelsMothersSexAdulthoodInternalizing psychopathologySignificant mediatorMediation analysisAssociation
2022
Maternal distress, DNA methylation, and fetal programing of stress physiology in Brazilian mother–infant pairs
Wiley K, Camilo C, Gouveia G, Euclydes V, Panter‐Brick C, Matijasevich A, Ferraro A, Fracolli L, Chiesa A, Miguel E, Polanczyk G, Brentani H. Maternal distress, DNA methylation, and fetal programing of stress physiology in Brazilian mother–infant pairs. Developmental Psychobiology 2022, 65: e22352. PMID: 36567654, PMCID: PMC9792831, DOI: 10.1002/dev.22352.Peer-Reviewed Original ResearchConceptsPrenatal psychological distressLate pregnancyMaternal prenatal psychosocial stressMaternal hair cortisolMaternal prenatal psychological distressPrenatal psychosocial stressPsychological distressAdrenal axis functionInfants of mothersEvening salivary cortisolMother-infant pairsInfant DNA methylationMultivariable linear regressionHair cortisol concentrationsElevated anxiety symptomsAxis functionFetal programingEvening cortisolPregnant adolescentsMaternal distressPsychosocial stressCortisol concentrationsPregnancyHair cortisolSalivary cortisolDisentangling the influences of parental genetics on offspring's cognition, education, and psychopathology via genetic and phenotypic pathways
Axelrud L, Hoffmann M, Vosberg D, Santoro M, Pan P, Gadelha A, Belangero S, Miguel E, Shin J, Thapar A, Smoller J, Pausova Z, Rohde L, Keller M, Paus T, Salum G. Disentangling the influences of parental genetics on offspring's cognition, education, and psychopathology via genetic and phenotypic pathways. Journal Of Child Psychology And Psychiatry 2022, 64: 408-416. PMID: 36162806, DOI: 10.1111/jcpp.13708.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderPolygenic scoresOffspring cognitionIntergenerational transmissionMultiple mediation modelEducational attainmentBehavioral traitsCognitive measuresExecutive functionGeneral intelligenceHyperactivity disorderMediation modelMultiple mediationCognitive AssessmentCognitionPsychopathologyGenetic influencesParental educationPsychotic symptomsDirect associationParental geneticsAttainmentDiscovery sampleGenetic riskFathersCo-Occurring Obsessive–Compulsive Disorder and Compulsive Sexual Behavior: Clinical Features and Psychiatric Comorbidities
Snaychuk L, Ferrão Y, Fontenelle L, Miguel E, de Mathis M, Scanavino M, Kim H. Co-Occurring Obsessive–Compulsive Disorder and Compulsive Sexual Behavior: Clinical Features and Psychiatric Comorbidities. Archives Of Sexual Behavior 2022, 51: 4111-4123. PMID: 36066680, DOI: 10.1007/s10508-022-02412-6.Peer-Reviewed Original ResearchConceptsCo-occurring obsessive-compulsive disorderObsessive-compulsive disorderPsychiatric comorbidityCompulsive sexual behaviorBinary logistic regression analysisComorbid obsessive-compulsive disorderGreater psychiatric comorbidityLogistic regression analysisComplex treatment needsSexual behaviorClinical characteristicsClinical factorsClinical featuresStandardized self-report measuresComorbiditiesControl disordersTreatment needsPsychiatric conditionsDisordersRegression analysisPreliminary evidenceSelf-report measuresCurrent studySemi-structured interviewsParticipantsAssociations between Family Functioning and Maternal Behavior on Default Mode Network Connectivity in School-Age Children
Rebello K, Moura L, Bueno A, Picon F, Pan P, Gadelha A, Miguel E, Bressan R, Rohde L, Sato J. Associations between Family Functioning and Maternal Behavior on Default Mode Network Connectivity in School-Age Children. International Journal Of Environmental Research And Public Health 2022, 19: 6055. PMID: 35627592, PMCID: PMC9141331, DOI: 10.3390/ijerph19106055.Peer-Reviewed Original ResearchConceptsDefault mode networkFamily Environment ScaleSchool-aged childrenPosterior cingulate cortexMedial prefrontal cortexFamily environmentFunctional connectivityDMN functional connectivityCohesive familiesMaternal behaviorDefault mode network connectivityFunctional magnetic resonance imaging (fMRI) dataEarly child experiencesPositive maternal behaviorParent-child relationshipMode network connectivityBrain functional connectivityChild affectFamily functioningMaternal overprotectionEarly adolescenceFamily cohesivenessMode networkPrefrontal cortexFamily contextPost-acute sequelae of SARS-CoV-2 infection: relationship of central nervous system manifestations with physical disability and systemic inflammation
Busatto G, de Araujo A, Castaldelli-Maia J, Damiano R, Imamura M, Guedes B, de Rezende Pinna F, Sawamura M, Mancini M, da Silva K, Garcia M, Sumita N, Brunoni A, da Silva Duarte A, Burdmann E, Kallas E, Cerri G, Nitrini R, Bento R, Rocha V, de Souza H, Miguel E, de Carvalho C, Forlenza O, Batistella L. Post-acute sequelae of SARS-CoV-2 infection: relationship of central nervous system manifestations with physical disability and systemic inflammation. Psychological Medicine 2022, 52: 2387-2398. PMID: 35521752, PMCID: PMC9151630, DOI: 10.1017/s0033291722001374.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionPost-acute sequelaeC-reactive proteinSystemic inflammationBlood levelsPhysical disabilityD-dimer blood levelsCentral nervous system manifestationsPersistent physical disabilityPersistent systemic inflammationNervous system manifestationsSevere COVID-19Cognitive manifestationsPoor physical performanceElevated blood levelsCoronavirus disease 2019Pattern of symptomsDifferent organ systemsExploratory factor analysisSame followSystem manifestationsD-dimerClinical manifestationsKidney dysfunctionPerson visitsDNA methylation mediates a randomized controlled trial home-visiting intervention during pregnancy and the Bayley infant’s cognitive scores at 12 months of age
Euclydes V, Gastaldi V, Feltrin A, Hoffman D, Gouveia G, Cogo H, Felipe-Silva A, Vieira R, Miguel E, Polanczyk G, Chiesa A, Fracolli L, Matijasevich A, Ferraro A, Argeu A, Maschietto M, Brentani H. DNA methylation mediates a randomized controlled trial home-visiting intervention during pregnancy and the Bayley infant’s cognitive scores at 12 months of age. Journal Of Developmental Origins Of Health And Disease 2022, 13: 556-565. PMID: 35256034, DOI: 10.1017/s2040174421000738.Peer-Reviewed Original ResearchInattention symptoms in early pregnancy predict parenting skills and infant maltreatment during the first year of life
de Oliveira J, Fatori D, Shephard E, Xavier M, Matijasevich A, Ferraro A, Rohde L, Chiesa A, Miguel E, Polanczyk G. Inattention symptoms in early pregnancy predict parenting skills and infant maltreatment during the first year of life. Brazilian Journal Of Psychiatry 2022, 44: 388-400. PMID: 35751597, PMCID: PMC9375657, DOI: 10.47626/1516-4446-2021-2045.Peer-Reviewed Original ResearchConceptsMaternal attention-deficit/hyperactivity disorderAttention-deficit/hyperactivity disorderHyperactivity/impulsivity symptomsInattention symptomsImpulsivity symptomsAdolescent mothersHyperactivity disorderMaternal inattentionInfant maltreatmentEarly intervention programsParenting skillsPoor home environmentInfant developmentIntervention programsInattentionChild maltreatmentMaternal competenceMaltreatmentSkillsHome visit programHome environmentFirst yearInfant's lifeMultilevel linear regression modelsEarly pregnancy
2021
Childhood poverty and mental health disorders in early adulthood: evidence from a Brazilian cohort study
Ziebold C, Evans-Lacko S, Andrade M, Hoffmann M, Fonseca L, Barbosa M, Pan P, Miguel E, Bressan R, Rohde L, Salum G, Schafer J, de Jesus Mari J, Gadelha A. Childhood poverty and mental health disorders in early adulthood: evidence from a Brazilian cohort study. European Child & Adolescent Psychiatry 2021, 32: 903-914. PMID: 34853911, DOI: 10.1007/s00787-021-01923-2.Peer-Reviewed Original ResearchConceptsMental health disordersStressful life eventsEarly adulthoodHealth disordersPreventable risk factorsDifferent stressful life eventsInternalizing disordersBrazilian cohort studyProspective community cohortWell-Being AssessmentCohort studyCommunity cohortRisk factorsStratified analysisPsychiatric diagnosisExternalizing disordersChildhood povertyDisordersBaselineAdulthoodStandardized classificationHigh exposureLife eventsAssociationYoung peopleCOMVC-19: A Program to protect healthcare workers' mental health during the COVID-19 Pandemic. What we have learned
Fukuti P, Uchôa C, Mazzoco M, da Cruz I, Echegaray M, de Castro Humes E, Silveira J, Di Santi T, Miguel E, Corchs F, program C, Fatori D, Campello G, de Oliveira G, Argolo F, de M. Ferreira F, Machado G, Argeu A, de Oliveira G, de Pádua Serafim A, de Lima Siqueira L, de Rossi L, Rios I, de Oliveira T, Antoniazzi L, Gagliotti D, Abelama E, de Oliveira P, Correia A, Gonçalves L, Tortato L, Busato W, Guimarães-Fernandes F, Alves M, Leite O, de Campos Lindenberg Schoueri P, de Assis Roque M, Merlin S, Boer G, Sallet P, Malbergier A, Spedo M, Kamitsuji C, de Faria E, de Godoy Moreira M, Kaufman A, Abdo C, de Tubino Scanavino M, Lancman S, Tavares H, Polanczyk G, Brunoni A, Forlenza O, de Barros-Filho T. COMVC-19: A Program to protect healthcare workers' mental health during the COVID-19 Pandemic. What we have learned. Clinics 2021, 76: e2631. PMID: 34817044, PMCID: PMC8579850, DOI: 10.6061/clinics/2021/e2631.Peer-Reviewed Original ResearchConceptsNursing staffHospital das Clinicas da FaculdadeHealthcare workers' mental healthMedicina da Universidade de São PauloMental healthCOVID-19 patientsMental health impairmentMental health treatmentCOVID-19 pandemicMental health programsWorkers' mental healthCommon diagnosisPreventive actionsSleep disturbancesMood disordersPsychiatric evaluationMultimodal interventionHealth treatmentDepression symptomsHealth programsPublic hospitalsHealth impairmentSymptomsMobile phone appMost participantsBrain areas involved with obsessive-compulsive disorder present different DNA methylation modulation
de Oliveira K, Camilo C, Gastaldi V, Sant’Anna Feltrin A, Lisboa B, de Jesus Rodrigues de Paula V, Moretto A, Lafer B, Hoexter M, Miguel E, Maschietto M, Brentani H. Brain areas involved with obsessive-compulsive disorder present different DNA methylation modulation. BMC Genomic Data 2021, 22: 45. PMID: 34717534, PMCID: PMC8557022, DOI: 10.1186/s12863-021-00993-0.Peer-Reviewed Original ResearchConceptsGene modulesMethylation changesBrain areasCpG sitesProtein-protein interaction networkDNA methylation modulationCommon transcriptional factorsDNA methylation changesSpecific signaling pathwaysGene expression dataOCD patientsPost-mortem brain tissueEpigenetic mechanismsInteraction networksMethylation modulationHypomethylation patternTranscriptional factorsEnvironmental risk factorsGene expressionBiological processesBackgroundObsessive–compulsive disorderSignaling pathwaysExpression dataG proteinsRisk factorsThe impact of child psychiatric conditions on future educational outcomes among a community cohort in Brazil
Hoffmann M, McDaid D, Salum G, Silva-Ribeiro W, Ziebold C, King D, Gadelha A, Miguel E, de Jesus Mari J, Rohde L, Pan P, Bressan R, Mojtabai R, Evans-Lacko S. The impact of child psychiatric conditions on future educational outcomes among a community cohort in Brazil. Epidemiology And Psychiatric Sciences 2021, 30: e69. PMID: 36178130, PMCID: PMC8581950, DOI: 10.1017/s2045796021000561.Peer-Reviewed Original ResearchConceptsBullying perpetrationAdverse educational outcomesPsychiatric conditionsEducational outcomesWell-Being Behavior AssessmentImpact of fearHigh family riskMental health problemsFamily riskLiteracy performanceGrade repetitionChild psychiatric conditionsFuture educational outcomesCommunity cohortPopulation attributable risk percentageSchool dropoutPerpetrationNegative long-term effectsSample attritionAttributable risk percentageLarge Brazilian cohortBehavior assessmentNegative impactRobust negative impactBrazilian childrenMental health conditions in Lesbian, Gay, Bisexual, Transgender, Queer and Asexual youth in Brazil: A call for action
Terra T, Schafer J, Pan P, Costa A, Caye A, Gadelha A, Miguel E, Bressan R, Rohde L, Salum G. Mental health conditions in Lesbian, Gay, Bisexual, Transgender, Queer and Asexual youth in Brazil: A call for action. Journal Of Affective Disorders 2021, 298: 190-193. PMID: 34715179, DOI: 10.1016/j.jad.2021.10.108.Peer-Reviewed Original ResearchConceptsAsexual youthMental disordersWell-Being Behavior AssessmentHigh-risk cohortMental health conditionsPost-traumatic stress disorderAttention deficit hyperactivity disorderMental health problemsDeficit hyperactivity disorderMental health disparitiesStressful life eventsDepressive disorderPsychiatric disordersPrevalence estimatesHealth problemsConfidential questionnaireHealth disparitiesLogistic regressionStress disorderAnxiety disordersHealth conditionsConduct disorderGroup comparisonsHyperactivity disorderDisordersLongitudinal associations between positive attributes and psychopathology and their interactive effects on educational outcomes
Romani-Sponchiado A, Vidal-Ribas P, Bressan R, de Jesus Mari J, Miguel E, Gadelha A, Rohde L, Evans-Lacko S, Salum G, Hoffmann M. Longitudinal associations between positive attributes and psychopathology and their interactive effects on educational outcomes. European Child & Adolescent Psychiatry 2021, 32: 463-474. PMID: 34559317, DOI: 10.1007/s00787-021-01882-8.Peer-Reviewed Original ResearchConceptsEducational outcomesSchool dropoutCross-lagged panel modelBetter educational outcomesLow literacy abilityPositive attributesLiteracy abilitiesLongitudinal impactGeneral factorDropoutConduct symptomsSchoolingLiteracyLearningConduct problemsYouthConstructsOutcomesPanel modelLongitudinal associationsAttributesA randomized controlled trial testing the efficacy of a Nurse Home Visiting Program for Pregnant Adolescents
Fatori D, Fonseca Zuccolo P, Shephard E, Brentani H, Matijasevich A, Archanjo Ferraro A, Aparecida Fracolli L, Chiesa AM, Leckman J, Constantino Miguel E, V. Polanczyk G. A randomized controlled trial testing the efficacy of a Nurse Home Visiting Program for Pregnant Adolescents. Scientific Reports 2021, 11: 14432. PMID: 34257407, PMCID: PMC8277870, DOI: 10.1038/s41598-021-93938-7.Peer-Reviewed Original ResearchConceptsWeeks of pregnancyAdolescent mothersNurse Home Visiting ProgramStandardized effect sizeChild's ageHome Visiting ProgramTrajectories of outcomesInfant Development-Third EditionEffect sizeLow-income adolescent mothersChildren's expressive language developmentAnthropometric indicesNurse homeDaily stimulationEndpoint assessmentBayley ScalesPregnant adolescentsVisiting ProgramExpressive language developmentPromising interventionChild developmentIntervention effectsPregnancyPoor urban areasAlpha frequencyThe price of love: an investigation into the relationship between romantic love and the expression of obsessive–compulsive disorder
McLauchlan J, Thompson E, Ferrão Y, Miguel E, Albertella L, Marazziti D, Fontenelle L. The price of love: an investigation into the relationship between romantic love and the expression of obsessive–compulsive disorder. CNS Spectrums 2021, 27: 691-698. PMID: 34039460, DOI: 10.1017/s1092852921000444.Peer-Reviewed Original ResearchCellular and Extracellular White Matter Abnormalities in Obsessive-Compulsive Disorder: A Diffusion Magnetic Resonance Imaging Study
Maziero M, Seitz-Holland J, Cho K, Goldenberg J, Tanamatis T, Diniz J, Cappi C, Alice de Mathis M, Otaduy M, da Graça Morais Martin M, de Melo Felipe da Silva R, Shavitt R, Batistuzzo M, Lopes A, Miguel E, Pasternak O, Hoexter M. Cellular and Extracellular White Matter Abnormalities in Obsessive-Compulsive Disorder: A Diffusion Magnetic Resonance Imaging Study. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2021, 6: 983-991. PMID: 33862255, PMCID: PMC8502196, DOI: 10.1016/j.bpsc.2021.04.001.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderClinical variablesControl subjectsLower fractional anisotropyFractional anisotropyWhite matterDiffusion-weighted magnetic resonance imagingMagnetic resonance imaging studyDiffusion measuresDiffusion magnetic resonance imaging studyWhite matter abnormalitiesTract-based spatial statisticsResonance imaging studyMagnetic resonance imagingFree-water imagingExtracellular abnormalitiesPromoting mother‐infant relationships and underlying neural correlates: Results from a randomized controlled trial of a home‐visiting program for adolescent mothers in Brazil
Alarcão FSP, Shephard E, Fatori D, Amável R, Chiesa A, Fracolli L, Matijasevich A, Brentani H, Nelson CA, Leckman J, Miguel EC, Polanczyk GV. Promoting mother‐infant relationships and underlying neural correlates: Results from a randomized controlled trial of a home‐visiting program for adolescent mothers in Brazil. Developmental Science 2021, 24: e13113. PMID: 33844435, PMCID: PMC8596406, DOI: 10.1111/desc.13113.Peer-Reviewed Original ResearchConceptsMother-infant attachmentHome visit programHealthy parent-child relationshipsEarly attachment relationshipsAdolescent mothersParent-child relationshipMother-infant interactionGood social behaviourMother-infant relationshipSocial processingAttachment relationshipsNeural correlatesNc amplitudeMother's faceElectrophysiological correlatesAge 6 monthsHome-visiting interventionInfant developmentSocial behaviorPregnant youthSecondary outcomesMiddle-income countriesFirst trimesterMother's healthIntervention group