2024
An evaluation of treatment response and remission definitions in adult obsessive-compulsive disorder: A systematic review and individual-patient data meta-analysis
Ramakrishnan D, Farhat L, Vattimo E, Levine J, Johnson J, Artukoglu B, Landeros-Weisenberger A, Zangen A, Pelissolo A, de B Pereira C, Rück C, Costa D, Mataix-Cols D, Shannahoff-Khalsa D, Tolin D, Zarean E, Meyer E, Hawken E, Storch E, Andersson E, Miguel E, Maina G, Leckman J, Sarris J, March J, Diniz J, Kobak K, Mallet L, Vulink N, Amiaz R, Fernandes R, Shavitt R, Wilhelm S, Golshan S, Tezenas du Montcel S, Erzegovesi S, Baruah U, Greenberg W, Kobayashi Y, Bloch M. An evaluation of treatment response and remission definitions in adult obsessive-compulsive disorder: A systematic review and individual-patient data meta-analysis. Journal Of Psychiatric Research 2024, 173: 387-397. PMID: 38598877, DOI: 10.1016/j.jpsychires.2024.03.044.Peer-Reviewed Original ResearchMeSH KeywordsAdultHumansObsessive-Compulsive DisorderPsychiatric Status Rating ScalesTreatment OutcomeConceptsYale-Brown Obsessive-Compulsive ScaleObsessive-compulsive disorderCGI-IRandomized-controlled trialsAdult obsessive-compulsive disorderClinical Global Impression ImprovementObsessive-Compulsive ScaleTreatment responseIndividual-patient data meta-analysisPosttreatment scoresEvaluation of treatment responseMeta-analysis of randomized-controlled trialsFirst-line therapyCGIIndividual participant dataMeta-analysisNovel treatment modalitiesExpert consensusIndividual participant data meta-analysisSystematic reviewDisordersData meta-analysisPosttreatmentRemission definitionsImpressive improvement
2023
Measurement Fidelity of Clinical Assessment Methods in a Global Study on Identifying Reproducible Brain Signatures of Obsessive–Compulsive Disorder
Shavitt R, Sheshachala K, Hezel D, Wall M, Balachander S, Lochner C, Narayanaswamy J, Costa D, de Mathis M, van Balkom A, de Joode N, Narayan M, van den Heuvel O, Stein D, Miguel E, Simpson H, Reddy Y. Measurement Fidelity of Clinical Assessment Methods in a Global Study on Identifying Reproducible Brain Signatures of Obsessive–Compulsive Disorder. Neuropsychology 2023, 37: 330-343. PMID: 36442004, PMCID: PMC10073274, DOI: 10.1037/neu0000849.Peer-Reviewed Original Research
2022
Factor structure of the Dimensional Yale-Brown Obsessive-Compulsive Scale in a large sample of adults with obsessive-compulsive disorder
Batistuzzo M, Fontenelle L, Ferrão Y, Rosário M, Miguel E, Fatori D. Factor structure of the Dimensional Yale-Brown Obsessive-Compulsive Scale in a large sample of adults with obsessive-compulsive disorder. Brazilian Journal Of Psychiatry 2022, 44: 57-60. PMID: 34878003, PMCID: PMC8827375, DOI: 10.1590/1516-4446-2021-2088.Peer-Reviewed Original ResearchAdultCross-Sectional StudiesHumansObsessive-Compulsive DisorderPsychiatric Status Rating ScalesPsychometricsReproducibility of ResultsSeverity of Illness Index
2020
Social losses predict a faster onset and greater severity of obsessive-compulsive disorder
Destrée L, Albertella L, Torres A, Ferrão Y, Shavitt R, Miguel E, Fontenelle L. Social losses predict a faster onset and greater severity of obsessive-compulsive disorder. Journal Of Psychiatric Research 2020, 130: 187-193. PMID: 32828024, DOI: 10.1016/j.jpsychires.2020.07.027.Peer-Reviewed Original ResearchMeSH KeywordsBrazilDiagnostic and Statistical Manual of Mental DisordersFemaleHumansMaleObsessive-Compulsive DisorderPsychiatric Status Rating ScalesSeverity of Illness IndexSurveys and QuestionnairesConceptsClinical obsessive-compulsive disorderObsessive-compulsive disorderStressful life eventsSpeed of progressionYale-Brown ObsessiveDSM-IV Axis I DisordersLife eventsCompulsive ScaleAxis I DisordersStructured Clinical InterviewSeverity of symptomsSymptom dimensionsBeck Depression InventorySubclinical obsessive-compulsive symptomsBeck Anxiety InventorySpecific obsessive-compulsive symptom dimensionsI disordersFaster onsetPsychiatric disordersHistory questionnaireBrown AssessmentClinical InterviewGreater severityDepression InventoryObsessive-compulsive symptomsIs it time to change the gold standard of obsessive-compulsive disorder severity assessment? Factor structure of the Yale-Brown Obsessive-Compulsive Scale
Fatori D, Costa D, Asbahr F, Ferrão Y, Rosário M, Miguel E, Shavitt R, Batistuzzo M. Is it time to change the gold standard of obsessive-compulsive disorder severity assessment? Factor structure of the Yale-Brown Obsessive-Compulsive Scale. Australian & New Zealand Journal Of Psychiatry 2020, 54: 732-742. PMID: 32475123, DOI: 10.1177/0004867420924113.Peer-Reviewed Original ResearchAdultHumansObsessive BehaviorObsessive-Compulsive DisorderPsychiatric Status Rating ScalesPsychometricsReproducibility of ResultsSeverity of Illness Index
2018
Dual diagnosis of obsessive compulsive and compulsive buying disorders: Demographic, clinical, and psychiatric correlates
Kim H, Hodgins D, Torres A, Fontenelle L, do Rosário M, de Mathis M, Ferrão Y, Miguel E, Tavares H. Dual diagnosis of obsessive compulsive and compulsive buying disorders: Demographic, clinical, and psychiatric correlates. Comprehensive Psychiatry 2018, 86: 67-73. PMID: 30081209, DOI: 10.1016/j.comppsych.2018.07.013.Peer-Reviewed Original ResearchConceptsCompulsive buying disorderObsessive-compulsive disorderBuying disorderComorbid obsessive-compulsive disorderDual diagnosisUnique clinical populationInternet use disordersDual diagnosis populationPsychiatric correlatesPsychiatric disordersPsychological mechanismsSocial phobiaOCD symptomsStructured Clinical InterviewClinical populationsSound measureLarge multi-centre studyClinical InterviewProtective factorsMulti-center studyUse disordersPresent researchTreatment utilityBinary logistic regressionCorrelates
2017
Personality measures after gamma ventral capsulotomy in intractable OCD
Paiva R, Batistuzzo M, McLaughlin N, Canteras M, de Mathis M, Requena G, Shavitt R, Greenberg B, Norén G, Rasmussen S, Tavares H, Miguel E, Lopes A, Hoexter M. Personality measures after gamma ventral capsulotomy in intractable OCD. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2017, 81: 161-168. PMID: 29100975, DOI: 10.1016/j.pnpbp.2017.10.023.Peer-Reviewed Original ResearchMeSH KeywordsAdultFemaleFollow-Up StudiesHumansInternal CapsuleLinear ModelsMaleObsessive-Compulsive DisorderPersonalityPersonality InventoryPsychiatric Status Rating ScalesRadiosurgeryTreatment OutcomeLow frequency fluctuation of brain spontaneous activity and obsessive-compulsive symptoms in a large school-age sample
Hoexter M, Biazoli C, Alvarenga P, Batistuzzo M, Salum G, Gadelha A, Pan P, Anés M, Mancini-Martins L, Moura L, Soriano-Mas C, Aquilla M, Amaro E, Rohde L, Jackowski A, Bressan R, Miguel E, do Rosario M, Sato J. Low frequency fluctuation of brain spontaneous activity and obsessive-compulsive symptoms in a large school-age sample. Journal Of Psychiatric Research 2017, 96: 224-230. PMID: 29102817, DOI: 10.1016/j.jpsychires.2017.10.009.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBrainBrain MappingChildCohort StudiesFemaleHumansMagnetic Resonance ImagingMaleObsessive-Compulsive DisorderPsychiatric Status Rating ScalesRestConceptsObsessive-compulsive symptomsBrain spontaneous activityLow-frequency fluctuationsSpontaneous activityRight sensorimotor cortexHigh Risk Cohort StudyState functional magnetic resonance imaging (rs-fMRI) dataSpontaneous activity changesPredictors of riskWell-Being AssessmentSpontaneous brain activitySuperior temporal cortexSuperior temporal gyrusCohort studyObsessive-compulsive disorderSensorimotor cortexMagnetic resonance imaging dataPsychiatric disordersOverall psychopathologyTemporal gyrusFractional amplitudeGeneral linear modelFunctional magnetic resonance imaging (fMRI) dataCompulsive symptomsBrain activityRandomized, Double-Blind, Placebo-Controlled Trial of N-Acetylcysteine Augmentation for Treatment-Resistant Obsessive-Compulsive Disorder.
Costa DLC, Diniz JB, Requena G, Joaquim MA, Pittenger C, Bloch MH, Miguel EC, Shavitt RG. Randomized, Double-Blind, Placebo-Controlled Trial of N-Acetylcysteine Augmentation for Treatment-Resistant Obsessive-Compulsive Disorder. The Journal Of Clinical Psychiatry 2017, 78: e766-e773. PMID: 28617566, DOI: 10.4088/jcp.16m11101.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcysteineAdolescentAdultAgedAnxiety DisordersComorbidityDepressive DisorderDouble-Blind MethodDrug ResistanceDrug Therapy, CombinationFemaleHumansMaleMiddle AgedObsessive-Compulsive DisorderPsychiatric Status Rating ScalesPsychometricsSelective Serotonin Reuptake InhibitorsYoung AdultConceptsTreatment-resistant obsessive-compulsive disorderObsessive-compulsive disorderY-BOCS scoresN-acetylcysteineNAC groupYale-Brown Obsessive Compulsive Scale scoresTreatment-resistant OCD patientsBaseline Y-BOCS scoresTreatment-Resistant ObsessivePrimary outcome measureAnxiety symptomsDSM-IV criteriaSymptom dimensionsCompulsive Scale scoresSpecific OCD symptom dimensionsOCD symptom dimensionsAntioxidant medicationsAbdominal painPlacebo groupGlutamate modulatorsSecondary outcomesTertiary hospitalOutpatient clinicSeverity scoreWeek 16Quantifying dimensional severity of obsessive-compulsive disorder for neurobiological research
Shavitt R, Requena G, Alonso P, Zai G, Costa D, de Bragança Pereira C, do Rosário M, Morais I, Fontenelle L, Cappi C, Kennedy J, Menchon J, Miguel E, Richter P. Quantifying dimensional severity of obsessive-compulsive disorder for neurobiological research. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2017, 79: 206-212. PMID: 28673486, DOI: 10.1016/j.pnpbp.2017.06.037.Peer-Reviewed Original ResearchAlgorithmsHumansLogistic ModelsModels, PsychologicalObsessive-Compulsive DisorderPhenotypePsychiatric Status Rating ScalesSeverity of Illness IndexThe Social Aptitudes Scale: looking at both “ends” of the social functioning dimension
Axelrud L, DeSousa D, Manfro G, Pan P, Knackfuss A, Mari J, Miguel E, Rohde L, Salum G. The Social Aptitudes Scale: looking at both “ends” of the social functioning dimension. Social Psychiatry And Psychiatric Epidemiology 2017, 52: 1031-1040. PMID: 28567593, DOI: 10.1007/s00127-017-1395-8.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAptitudeBrazilChildFemaleHumansMalePsychiatric Status Rating ScalesReproducibility of ResultsSocial AdjustmentSocial Behavior DisordersConceptsSocial aptitudeSocial functioningChild Behavior ChecklistSocial problemsAtypical developmentItem response theoryBehavior ChecklistHuman behaviorDimensional assessmentDistinct aspectsSocial functioning dimensionsFurther validityAptitudeResponse theoryFunctioningCaptures variabilityNon-significant correlationSpecific and social fears in children and adolescents: separating normative fears from problem indicators and phobias
Laporte P, Pan P, Hoffmann M, Wakschlag L, Rohde L, Miguel E, Pine D, Manfro G, Salum G. Specific and social fears in children and adolescents: separating normative fears from problem indicators and phobias. Brazilian Journal Of Psychiatry 2017, 39: 118-125. PMID: 28300935, PMCID: PMC7111439, DOI: 10.1590/1516-4446-2016-2064.Peer-Reviewed Original ResearchThe Child Behavior Checklist—Obsessive-Compulsive Subscale Detects Severe Psychopathology and Behavioral Problems Among School-Aged Children
Saad LO, do Rosario MC, Cesar RC, Batistuzzo MC, Hoexter MQ, Manfro GG, Shavitt RG, Leckman JF, Miguel EC, Alvarenga PG. The Child Behavior Checklist—Obsessive-Compulsive Subscale Detects Severe Psychopathology and Behavioral Problems Among School-Aged Children. Journal Of Child And Adolescent Psychopharmacology 2017, 27: 342-348. PMID: 28151703, PMCID: PMC5439443, DOI: 10.1089/cap.2016.0125.Peer-Reviewed Original ResearchConceptsObsessive-compulsive symptomsPsychiatric comorbidityPredictive valueBehavioral problemsDSM-IV psychiatric diagnosesPresence of OCSGroup of patientsHigh-risk cohortSignificant obsessive-compulsive symptomsNegative predictive valuePositive predictive valueHigh rateSeverity of OCSRisk cohortSchool-Aged ChildrenDepressive disorderFunctional impairmentPsychiatric diagnosisChild Behavior ChecklistComorbiditiesSevere psychopathologyBeing AssessmentScreening toolPediatric OCDAnxiety disorders
2016
Epigenetic evidence for involvement of the oxytocin receptor gene in obsessive–compulsive disorder
Cappi C, Diniz J, Requena G, Lourenço T, Lisboa B, Batistuzzo M, Marques A, Hoexter M, Pereira C, Miguel E, Brentani H. Epigenetic evidence for involvement of the oxytocin receptor gene in obsessive–compulsive disorder. BMC Neuroscience 2016, 17: 79. PMID: 27903255, PMCID: PMC5131547, DOI: 10.1186/s12868-016-0313-4.Peer-Reviewed Original ResearchTranscranial direct current stimulation for treatment-resistant obsessive-compulsive disorder: report on two cases and proposal for a randomized, sham-controlled trial
da Silva R, Brunoni A, Miguel E, Shavitt R. Transcranial direct current stimulation for treatment-resistant obsessive-compulsive disorder: report on two cases and proposal for a randomized, sham-controlled trial. Sao Paulo Medical Journal 2016, 134: 446-450. PMID: 27901245, PMCID: PMC10871858, DOI: 10.1590/1516-3180.2016.0155010716.Peer-Reviewed Original ResearchConceptsTreatment-resistant obsessive-compulsive disorderTranscranial direct current stimulationObsessive-compulsive disorderDirect current stimulationClinical trialsCurrent stimulationSham-controlled trialSerotonin reuptake inhibitorsSupplementary motor cortexPrimary obsessive-compulsive disorderCognitive behavioral therapySecondary outcomesPrimary outcomeReuptake inhibitorsSham interventionFirst patientCortical excitabilityMotor cortexUniversity HospitalWeek 4YBOCS scoresNeuromodulation techniquesNon-invasive techniqueBrain circuitsPatientsHow Similar Are the Disorders Included Under the Umbrella of Obsessive-Compulsive Disorder and Related Disorders?
Costa D, Diniz J, Miguel E. How Similar Are the Disorders Included Under the Umbrella of Obsessive-Compulsive Disorder and Related Disorders? JAMA Psychiatry 2016, 73: 877. PMID: 27409717, DOI: 10.1001/jamapsychiatry.2016.1342.Peer-Reviewed Original ResearchUse of benzodiazepines in obsessive–compulsive disorder
Starcevic V, Berle D, do Rosário M, Brakoulias V, Ferrão Y, Viswasam K, Shavitt R, Miguel E, Fontenelle L. Use of benzodiazepines in obsessive–compulsive disorder. International Clinical Psychopharmacology 2016, 31: 27-33. PMID: 26426443, DOI: 10.1097/yic.0000000000000100.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-Anxiety AgentsAnxietyBenzodiazepinesCross-Sectional StudiesDiagnostic and Statistical Manual of Mental DisordersDrug Therapy, CombinationFemaleHumansMaleMiddle AgedObsessive-Compulsive DisorderPsychiatric Status Rating ScalesSelective Serotonin Reuptake InhibitorsSocioeconomic FactorsConceptsObsessive-compulsive disorderBDZ useOCD patientsUse of benzodiazepinesTreatment of OCDBrazilian Research ConsortiumAdditional medicationTreatment guidelinesMulticentre studyReuptake inhibitorsObsessive-compulsive spectrum disordersBenzodiazepine useMarked anxietyPatientsMedicationsBDZDisordersResearch ConsortiumCurrent age
2015
Positive Attributes Buffer the Negative Associations Between Low Intelligence and High Psychopathology With Educational Outcomes
Hoffmann M, Leibenluft E, Stringaris A, Laporte P, Pan P, Gadelha A, Manfro G, Miguel E, Rohde L, Salum G. Positive Attributes Buffer the Negative Associations Between Low Intelligence and High Psychopathology With Educational Outcomes. Journal Of The American Academy Of Child & Adolescent Psychiatry 2015, 55: 47-53. PMID: 26703909, PMCID: PMC4695393, DOI: 10.1016/j.jaac.2015.10.013.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBehavior Rating ScaleBrazilChildEducational StatusFemaleHumansIntelligenceIntelligence TestsLinear ModelsMaleMental DisordersModels, PsychologicalPsychiatric Status Rating ScalesSchoolsConceptsNegative educational outcomesConfirmatory factor analysisEducational outcomesPoor academic performanceLow intelligenceHigher psychopathologyAcademic performancePositive attributesNegative school outcomesPsychiatric symptomsHigher psychiatric symptomsDistinct constructsSchool outcomesEducational problemsCommunity sampleDiscriminant validityPsychopathologyNegative effectsFactor analysisIntelligenceMain effectEquation modelNegative associationAttribute changesLow levelsDefining clinical severity in adults with obsessive–compulsive disorder
Storch E, De Nadai A, do Rosário M, Shavitt R, Torres A, Ferrão Y, Miguel E, Lewin A, Fontenelle L. Defining clinical severity in adults with obsessive–compulsive disorder. Comprehensive Psychiatry 2015, 63: 30-35. PMID: 26555489, PMCID: PMC4643407, DOI: 10.1016/j.comppsych.2015.08.007.Peer-Reviewed Original ResearchBrain structural correlates of sensory phenomena in patients with obsessive–compulsive disorder
Subirà M, Sato J, Alonso P, do Rosário M, Segalàs C, Batistuzzo M, Real E, Lopes A, Cerrillo E, Diniz J, Pujol J, Assis R, Menchón J, Shavitt R, Busatto G, Cardoner N, Miguel E, Hoexter M, Soriano-Mas C. Brain structural correlates of sensory phenomena in patients with obsessive–compulsive disorder. Journal Of Psychiatry And Neuroscience 2015, 40: 232-240. PMID: 25652753, PMCID: PMC4478056, DOI: 10.1503/jpn.140118.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrainBrazilFemaleGray MatterHumansMagnetic Resonance ImagingMaleObsessive-Compulsive DisorderOrgan SizePerceptionPsychiatric Status Rating ScalesSpainConceptsGray matter volume increasesObsessive-compulsive disorderSensorimotor cortexHealthy controlsSensory phenomenaGray matter volume differencesLeft sensorimotor cortexStructural correlatesBrain structural correlatesVoxel-based morphometryMagnetic resonance examinationMost patientsSuch patientsTic onsetCortex abnormalitiesTic disordersPremotor cortexPatientsResonance examinationVolume increaseSpecialized unitsCortexParticipant recruitmentDisorders StudyDifferent centers