2024
F18. ROLE OF PSYCHIATRIC-ASSOCIATED SNVS IN THE EARLY ADULTHOOD: INSIGHTS FROM LONGITUDINAL NEUROIMAGING
Ito L, Ota V, Fernandes D, Martins A, Carvalho C, Zugman A, Sato J, Bressan R, Miguel E, Pan P, Salum G, Belangero S, Santoro M. F18. ROLE OF PSYCHIATRIC-ASSOCIATED SNVS IN THE EARLY ADULTHOOD: INSIGHTS FROM LONGITUDINAL NEUROIMAGING. European Neuropsychopharmacology 2024, 87: 214-215. DOI: 10.1016/j.euroneuro.2024.08.429.Peer-Reviewed Original ResearchPost-traumatic stress disorderAttention deficit/hyperactivity disorderBrain regionsBipolar disorderMental conditionBrain structuresBrazilian High-Risk Cohort StudyPrefrontal cortex regionsFrontal pole regionsHigh Risk Cohort StudyLateral orbitofrontal regionGenome-wide association studiesSignificant main effectDepressive disorderMixed-effects modelsStress disorderDeficit/hyperactivity disorderFrontal cortexOrbitofrontal regionsBiological underpinningsGenetic influencesCortex regionsLongitudinal relationshipIntracranial volumeEarly adulthood
2022
World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for treatment of anxiety, obsessive-compulsive and posttraumatic stress disorders – Version 3. Part I: Anxiety disorders
Bandelow B, Allgulander C, Baldwin D, da Conceição Costa D, Denys D, Dilbaz N, Domschke K, Eriksson E, Fineberg N, Hättenschwiler J, Hollander E, Kaiya H, Karavaeva T, Kasper S, Katzman M, Kim Y, Inoue T, Lim L, Masdrakis V, Menchón J, Miguel E, Möller H, Nardi A, Pallanti S, Perna G, Rujescu D, Starcevic V, Stein D, Tsai S, Van Ameringen M, Vasileva A, Wang Z, Zohar J. World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for treatment of anxiety, obsessive-compulsive and posttraumatic stress disorders – Version 3. Part I: Anxiety disorders. The World Journal Of Biological Psychiatry 2022, 24: 79-117. PMID: 35900161, DOI: 10.1080/15622975.2022.2086295.Peer-Reviewed Original ResearchConceptsSocial anxiety disorderCognitive behavioral therapyAnxiety disordersPanic disorder/agoraphobiaMixed anxiety disordersPosttraumatic stress disorderSerotonin-norepinephrine reuptake inhibitorsSelective serotonin reuptake inhibitorsTreatment of anxietyFirst-line psychotherapySelective mutismBehavioral therapySeparation anxietyStress disorderSpecific phobiaObsessive-CompulsiveReuptake inhibitorsAnxietyNon-pharmacological interventionsBiological Psychiatry (WFSBP) GuidelinesFirst-line medicationSerotonin reuptake inhibitorsAdolescentsAssessment of medicationsPsychotherapyDimensions of emotional distress among Brazilian workers in a COVID-19 reference hospital: A factor analytical study
Carvalho-Alves M, Petrilli-Mazon V, Brunoni A, Malbergier A, Fukuti P, Polanczyk G, Miguel E, Corchs F, Wang Y. Dimensions of emotional distress among Brazilian workers in a COVID-19 reference hospital: A factor analytical study. World Journal Of Psychiatry 2022, 12: 843-859. PMID: 35978972, PMCID: PMC9258270, DOI: 10.5498/wjp.v12.i6.843.Peer-Reviewed Original ResearchCOVID-19 reference hospitalHospital workersMental healthReference hospitalSleep changesDevastating public health crisisPatient Health Questionnaire-9Emotional domainsGeneralized Anxiety Disorder-7COVID-19 hospitalCoronavirus disease 2019 (COVID-19) pandemicPresence of symptomsAnxiety Disorder-7Emotional distressSignificant protective factorDisease 2019 pandemicPost-traumatic stress disorderWorkers' mental healthEvent Scale-RevisedPublic health crisisQuestionnaire-9Observational studyHealth systemProtective factorsStress disorderThe Phenomenology of Obsessive–Compulsive Symptoms in Tourette Syndrome
Ferrão Y, de Alvarenga P, Hounie A, de Mathis M, Farhat L, do Rosário M, Miguel E. The Phenomenology of Obsessive–Compulsive Symptoms in Tourette Syndrome. 2022, 45-64. DOI: 10.1093/med/9780197543214.003.0004.Peer-Reviewed Original ResearchTourette syndromeObsessive-compulsive disorderObsessive-compulsive symptomsComorbid obsessive-compulsive disorderPost-traumatic stress disorderAttention-deficit/hyperactivity disorderPsychiatric comorbidityBasal gangliaBehavioral comorbiditiesSeparation anxiety disorderTreatment approachesClinical practiceComorbid diagnosesSymptom presentationComorbiditiesSimple phobiaStress disorderAnxiety disordersHyperactivity disorderSymptomsDisordersGenetic vulnerabilityBehavioral problemsSyndromePost-COVID-19 psychiatric and cognitive morbidity: Preliminary findings from a Brazilian cohort study
Damiano R, Caruso M, Cincoto A, de Almeida Rocca C, de Pádua Serafim A, Bacchi P, Guedes B, Brunoni A, Pan P, Nitrini R, Beach S, Fricchione G, Busatto G, Miguel E, Forlenza O, Group H. Post-COVID-19 psychiatric and cognitive morbidity: Preliminary findings from a Brazilian cohort study. General Hospital Psychiatry 2022, 75: 38-45. PMID: 35134702, PMCID: PMC8734055, DOI: 10.1016/j.genhosppsych.2022.01.002.Peer-Reviewed Original ResearchConceptsCognitive morbidityCognitive outcomesAnxiety disordersPost-traumatic stress disorderRelevant psychosocial variablesCognitive batteryMemory declineStructured psychiatric interviewStress disorderPsychosocial variablesStandardized measuresPsychosocial stressorsPsychometric testsCognitive impairmentPsychiatric interviewSevere formPreliminary findingsSARS-CoV-2 infectionCohort of survivorsLong-term outcomesAcute-phase diseaseBrazilian cohort studyCOVID-19DisordersDepression
2021
Mental health conditions in Lesbian, Gay, Bisexual, Transgender, Queer and Asexual youth in Brazil: A call for action
Terra T, Schafer J, Pan P, Costa A, Caye A, Gadelha A, Miguel E, Bressan R, Rohde L, Salum G. Mental health conditions in Lesbian, Gay, Bisexual, Transgender, Queer and Asexual youth in Brazil: A call for action. Journal Of Affective Disorders 2021, 298: 190-193. PMID: 34715179, DOI: 10.1016/j.jad.2021.10.108.Peer-Reviewed Original ResearchConceptsAsexual youthMental disordersWell-Being Behavior AssessmentHigh-risk cohortMental health conditionsPost-traumatic stress disorderAttention deficit hyperactivity disorderMental health problemsDeficit hyperactivity disorderMental health disparitiesStressful life eventsDepressive disorderPsychiatric disordersPrevalence estimatesHealth problemsConfidential questionnaireHealth disparitiesLogistic regressionStress disorderAnxiety disordersHealth conditionsConduct disorderGroup comparisonsHyperactivity disorderDisorders
2020
Stressful Life Events and the Clinical Expression of Obsessive–Compulsive Disorder (OCD): An Exploratory Study
Imthon A, Caldart C, do Rosário M, Fontenelle L, Miguel E, Ferrão Y. Stressful Life Events and the Clinical Expression of Obsessive–Compulsive Disorder (OCD): An Exploratory Study. Journal Of Clinical Medicine 2020, 9: 3371. PMID: 33096706, PMCID: PMC7590000, DOI: 10.3390/jcm9103371.Peer-Reviewed Original ResearchStressful life eventsObsessive-compulsive disorderPost-traumatic stress disorderOCD patientsOccurrence of SLEsNonwhite skin colorLife eventsLogistic regression variablesCross-sectional studySensory phenomenaYale-Brown ObsessiveClinical characteristicsClinical expressionPsychiatric disordersHistory questionnairePatientsObsessive-compulsive symptomsStress disorderCompulsive ScaleDimensional Yale-Brown ObsessiveStatistical significanceDisordersPositive associationOCD symptomsSymptoms
2013
Late-onset obsessive-compulsive disorder: Risk factors and correlates
Frydman I, do Brasil PE, Torres AR, Shavitt RG, Ferrão YA, Rosário MC, Miguel EC, Fontenelle LF. Late-onset obsessive-compulsive disorder: Risk factors and correlates. Journal Of Psychiatric Research 2013, 49: 68-74. PMID: 24267559, DOI: 10.1016/j.jpsychires.2013.10.021.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderLate-onset obsessive-compulsive disorderSubclinical obsessive-compulsive symptomsPosttraumatic stress disorderObsessive-compulsive symptomsOnset obsessive-compulsive disorderObsessive-compulsive spectrum disordersMajor traumatic eventEarly-onset obsessive-compulsive disorderBrazilian Research ConsortiumTraumatic eventsSpectrum disorderStress disorderOCD symptomsOCD onsetDearth of studiesSelfCorrelatesDisordersPotential variablesNeural networkDistressSymptomsSizeable proportionSeries of modelsThe Phenomenology of Obsessive-Compulsive Symptoms in Tourette Syndrome
FerrãO Y, De Alvarenga P, Hounie A, De Mathis M, De RosáRio M, Miguel E. The Phenomenology of Obsessive-Compulsive Symptoms in Tourette Syndrome. 2013, 50-73. DOI: 10.1093/med/9780199796267.003.0003.Peer-Reviewed Original ResearchObsessive-compulsive disorderTourette syndromeObsessive-compulsive symptomsComorbid obsessive-compulsive disorderAttention-deficit/hyperactivity disorderPosttraumatic stress disorderPsychiatric comorbidityBehavioral comorbiditiesSeparation anxiety disorderClinical practiceComorbid diagnosesComorbiditiesSymptomsSimple phobiaStress disorderAnxiety disordersHyperactivity disorderDisordersSyndromeBehavioral problems2711 – Trajectory of comorbidity in obsessive-compulsive disorder
de Mathis A, Diniz J, Shavitt R, do Rosário M, Miguel E. 2711 – Trajectory of comorbidity in obsessive-compulsive disorder. European Psychiatry 2013, 28: 1. DOI: 10.1016/s0924-9338(13)77321-8.Peer-Reviewed Original ResearchComorbid psychiatric disordersFirst diagnosisPsychiatric disordersOCD patientsAnxiety disordersMain psychiatric diagnosisPost-traumatic stress disorderClinical manifestationsComorbid schizophreniaMean ageObsessive-compulsive disorderTic disordersSeparation anxiety disorderSomatoform disordersComorbid disordersPsychiatric diagnosisPanic disorderPatientsSubstance abuseSimple phobiaStress disorderHigh frequencyOCD outpatientsDiagnosisDisorders
2011
Towards a post-traumatic subtype of obsessive–compulsive disorder
Fontenelle L, Cocchi L, Harrison B, Shavitt R, do Rosário M, Ferrão Y, de Mathis M, Cordioli A, Yücel M, Pantelis C, de Jesus Mari J, Miguel E, Torres A. Towards a post-traumatic subtype of obsessive–compulsive disorder. Journal Of Anxiety Disorders 2011, 26: 377-383. PMID: 22230220, DOI: 10.1016/j.janxdis.2011.12.001.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderObsessive-compulsive symptomsOCD patientsPost-traumatic stress disorderOnset of OCDCompulsive buying disorderHistory of PTSDTraumatic eventsStress disorderBuying disorderOCD onsetPanic disorderPTSDAlcohol-related disordersClinical featuresDisordersEducational levelMultinomial logistic regression analysisLogistic regression analysisSuicide planEarly ageLow educational levelMiscellaneous symptomsLater ageRegression analysisRole of stressful and traumatic life events in obsessive–compulsive disorder
Fontenelle L, Cocchi L, Harrison B, Miguel E, Torres A. Role of stressful and traumatic life events in obsessive–compulsive disorder. Neuropsychiatry 2011, 1: 61-69. DOI: 10.2217/npy.10.1.Peer-Reviewed Original ResearchCognitive Dysfunction in Post-Traumatic Obsessive–Compulsive Disorder
Borges M, Braga D, Iêgo S, D'Alcante C, Sidrim I, Machado M, Pinto P, Cordioli A, do Rosário M, Petribú K, Mendlowicz M, Mari J, Miguel E, Fontenelle L. Cognitive Dysfunction in Post-Traumatic Obsessive–Compulsive Disorder. Australian & New Zealand Journal Of Psychiatry 2011, 45: 76-85. PMID: 21174503, DOI: 10.3109/00048674.2010.527822.Peer-Reviewed Original ResearchConceptsSet-shifting abilityObsessive-compulsive disorderPoor set-shifting abilitiesWechsler Memory Scale-Logical MemoryBrief Visual Memory TestWisconsin Card Sorting TestVisual memory testsIowa Gambling TaskCard Sorting TestFollowing neuropsychological testsWechsler Abbreviated ScaleTypes of OCDPosttraumatic stress disorderObsessive-compulsive symptomsMemory testVisuospatial memoryGambling TaskLogical memorySorting TestAbbreviated ScaleNeurocognitive patternsNeuropsychological testsStress disorderVisuospatial recognitionCompulsive disorder
2009
The impact of trauma and post-traumatic stress disorder on the treatment response of patients with obsessive-compulsive disorder
Shavitt R, Valério C, Fossaluza V, da Silva E, Cordeiro Q, Diniz J, Belotto-Silva C, Cordioli A, Mari J, Miguel E. The impact of trauma and post-traumatic stress disorder on the treatment response of patients with obsessive-compulsive disorder. European Archives Of Psychiatry And Clinical Neuroscience 2009, 260: 91-99. PMID: 20077119, DOI: 10.1007/s00406-009-0015-3.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge of OnsetAnxietyDepressionDiagnostic and Statistical Manual of Mental DisordersFemaleFollow-Up StudiesHumansMaleMiddle AgedObsessive-Compulsive DisorderPsychiatric Status Rating ScalesSelective Serotonin Reuptake InhibitorsStatistics, NonparametricStress Disorders, Post-TraumaticTreatment OutcomeConceptsHistory of traumaPost-traumatic stress disorderObsessive-compulsive disorderTreatment responseHT groupBeck Depression InventoryPTSD groupBeck Anxiety InventorySpecific OCD symptom dimensionsConventional treatmentOCD symptom dimensionsOCD patientsSelective serotonin reuptake inhibitorsStress disorderFull DSM-IV criteriaFirst-line treatmentSerotonin reuptake inhibitorsCase series studyPoor treatment responseResistant OCD patientsSymptom dimensionsGreater treatment responseDSM-IV criteriaGreater reductionGroup cognitive behavioral therapy
2008
World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for the Pharmacological Treatment of Anxiety, Obsessive-Compulsive and Post-Traumatic Stress Disorders – First Revision
Bandelow B, Zohar J, Hollander E, Kasper S, Möller H, Zohar J, Hollander E, Kasper S, Möller H, Bandelow B, Allgulander C, Ayuso-Gutierrez J, Baldwin D, Buenvicius R, Cassano G, Fineberg N, Gabriels L, Hindmarch I, Kaiya H, Klein D, Lader M, Lecrubier Y, Lépine J, Liebowitz M, Lopez-Ibor J, Marazziti D, Miguel E, Oh K, Preter M, Rupprecht R, Sato M, Starcevic V, Stein D, van Ameringen M, Vega J. World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for the Pharmacological Treatment of Anxiety, Obsessive-Compulsive and Post-Traumatic Stress Disorders – First Revision. The World Journal Of Biological Psychiatry 2008, 9: 248-312. PMID: 18949648, DOI: 10.1080/15622970802465807.Peer-Reviewed Original ResearchConceptsSerotonin-noradrenaline reuptake inhibitorsPost-traumatic stress disorderSelective serotonin reuptake inhibitorsObsessive-compulsive disorderPharmacological treatmentCognitive behavioral therapyReuptake inhibitorsStress disorderTricyclic antidepressantsSSRI/SNRIAnxiety disordersBiological Psychiatry (WFSBP) GuidelinesFirst-line treatmentRelapse prevention studySerotonin reuptake inhibitorsTreatment-resistant casesPotential treatment optionSubstance abuse disordersWorld FederationObsessive-CompulsiveStudy of anxiolyticsOpen studySustained efficacyStandard treatmentTreatment options