2022
Association between chemosensory impairment with neuropsychiatric morbidity in post-acute COVID-19 syndrome: results from a multidisciplinary cohort study
Damiano R, Neto D, Oliveira J, Magalhães Santos J, Alves J, Guedes B, Nitrini R, de Araújo A, Oliveira M, Brunoni A, Voegels R, Bento R, Busatto G, Miguel E, Forlenza O, de Rezende Pinna F. Association between chemosensory impairment with neuropsychiatric morbidity in post-acute COVID-19 syndrome: results from a multidisciplinary cohort study. European Archives Of Psychiatry And Clinical Neuroscience 2022, 273: 325-333. PMID: 35633395, PMCID: PMC9142732, DOI: 10.1007/s00406-022-01427-3.Peer-Reviewed Original ResearchConceptsCohort studyChemosensory impairmentPost-acute COVID-19 syndromeCOVID-19 syndromeCentral nervous systemCOVID-19SARS-CoV-2Word list memory taskEpisodic memory impairmentSmell functionAdult patientsChemosensory dysfunctionAcute phaseNeuropsychiatric symptomsNeuropsychiatric morbidityGustatory lossHospitalization dataNeuropsychiatric impairmentEligible individualsSevere formCognition dysfunctionNervous systemMemory impairmentMultivariate analysisNeuropsychiatric disordersLatency to treatment seeking in patients with obsessive-compulsive disorder: Results from a large multicenter clinical sample
Costa D, de Campos A, Pereira C, Torres A, Dos Santos A, Requena G, Ferrão Y, do Rosário M, Miguel E, Simpson H, Shavitt R, Diniz J. Latency to treatment seeking in patients with obsessive-compulsive disorder: Results from a large multicenter clinical sample. Psychiatry Research 2022, 312: 114567. PMID: 35490573, DOI: 10.1016/j.psychres.2022.114567.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderEarly onsetOne-thirdCross-sectional studyInterval-censored survival modelClinical characteristicsOlder patientsSymptom awarenessPatientsNeuropsychiatric disordersSymptomsOlder ageOCD patientsContamination/Clinical samplesDisordersAggression symptomsOCD symptomsMore yearsTreatmentSurvival modelsOnsetYearsFull-time employmentComorbidities
2020
Cutting-edge genetics in obsessive-compulsive disorder
Saraiva L, Cappi C, Simpson H, Stein D, Viswanath B, van den Heuvel O, Reddy Y, Miguel E, Shavitt R. Cutting-edge genetics in obsessive-compulsive disorder. Faculty Reviews 2020, 9: 30. PMID: 33659962, PMCID: PMC7886082, DOI: 10.12703/r/9-30.Peer-Reviewed Original ResearchGenetic architectureWide association studyNumber variation studiesCutting-edge geneticsWhole-exome sequencing studiesUnderlying biological pathwaysHuman cell modelsGene networksStudy of endophenotypesGene expressionBiological pathwaysSequencing studiesAssociation studiesAnimal systemsGeneticsGene-environment interactionsCell modelBiological basisPolygenic risk scoresEvidence pointsSynaptic transmissionRecent advancesVariation studiesExperimental animal systemsNeuropsychiatric disorders
2019
Obsessive–compulsive disorder
Stein D, Costa D, Lochner C, Miguel E, Reddy Y, Shavitt R, van den Heuvel O, Simpson H. Obsessive–compulsive disorder. Nature Reviews Disease Primers 2019, 5: 52. PMID: 31371720, PMCID: PMC7370844, DOI: 10.1038/s41572-019-0102-3.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderSimilar symptom dimensionsExtent of comorbiditySpecific brain circuitsGroup of conditionsTranslational Neuroscience ApproachCognitive behavioral therapyIntractable symptomsReuptake inhibitorsClinical outcomesChronic conditionsGlobal disabilityEffective treatmentInternational ClassificationGlobal mental healthRelated disordersMental disordersNeuropsychiatric disordersRepetitive stereotyped behaviorsBrain circuitsIndividualized assessmentMental healthNeurobiological mechanismsStatistical ManualHomogenous disorder
2017
Effects of the brain-derived neurotropic factor variant Val66Met on cortical structure in late childhood and early adolescence
de Araujo C, Zugman A, Swardfager W, Belangero S, Ota V, Spindola L, Hakonarson H, Pellegrino R, Gadelha A, Salum G, Pan P, de Moura L, Del Aquilla M, Picon F, Amaro E, Sato J, Brietzke E, Grassi-Oliveira R, Rohde L, Miguel E, Bressan R, Jackowski A. Effects of the brain-derived neurotropic factor variant Val66Met on cortical structure in late childhood and early adolescence. Journal Of Psychiatric Research 2017, 98: 51-58. PMID: 29288952, DOI: 10.1016/j.jpsychires.2017.12.008.Peer-Reviewed Original ResearchConceptsPsychiatric disordersVal66Met polymorphismCortical thicknessBrain-derived neurotrophic factor (BDNF) Val66Met polymorphismRegional structural brain changesNeurotrophic factor Val66Met polymorphismPrefrontal cortexStructural brain changesLateral temporal cortexEffect of Val66MetBilateral prefrontal cortexVal66Met effectsWindow of vulnerabilityCortical maturationBrain changesOccipital lobeMet carriersAtypical neurodevelopmentMRI scansPsychiatric diagnosisTemporal cortexDiagnosis interactionVal66MetNeuropsychiatric disordersBrain morphology
2016
DBS for Obesity
Franco R, Fonoff E, Alvarenga P, Lopes A, Miguel E, Teixeira M, Damiani D, Hamani C. DBS for Obesity. Brain Sciences 2016, 6: 21. PMID: 27438859, PMCID: PMC5039450, DOI: 10.3390/brainsci6030021.Peer-Reviewed Original ResearchDeep brain stimulationMorbid obesityUse of DBSDifferent brain targetsNon-negligible incidenceNeurosurgical modalityNumerous comorbiditiesRefractory obesityBariatric surgeryOperative failureEarly mortalitySurgical resultsBrain targetsPrevalent disorderBrain stimulationSide effectsObesityNeuropsychiatric disordersDisordersComorbiditiesPatientsSurgeryBehavioral approachMortalityIncidence
2001
Síndrome de Gilles de la Tourette: estudo clínico de 58 casos
Chien H, Barbosa E, Miguel E. Síndrome de Gilles de la Tourette: estudo clínico de 58 casos. Arquivos De Neuro-Psiquiatria 2001, 59: 729-732. PMID: 11593274, DOI: 10.1590/s0004-282x2001000500015.Peer-Reviewed Original ResearchConceptsGilles de la Tourette's syndromeGilles de la TouretteLa Tourette's syndromeAge of onsetObsessive-compulsive disorderFemale ratioInitial symptomsMotor ticsVocal ticsChildhood onsetAssociated manifestationsComplex ticsTourette syndromePatientsNeuropsychiatric disordersHyperactivity disorderAge rangeAttention deficitsDisordersSyndromeSensory phenomenaOnsetYearsCopropraxiaLa Tourette
2000
The Psychiatric Symptoms of Rheumatic Fever
Mercadante MT, Busatto GF, Lombroso PJ, Prado L, Rosário-Campos MC, do Valle R, Marques-Dias MJ, Kiss MH, Leckman JF, Miguel EC. The Psychiatric Symptoms of Rheumatic Fever. American Journal Of Psychiatry 2000, 157: 2036-2038. PMID: 11097972, DOI: 10.1176/appi.ajp.157.12.2036.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderRheumatic feverSydenham's choreaTic disordersHigh riskComparison groupFever groupMajor depressive disorderDeficit hyperactivity disorderObsessive-compulsive disorderDepressive disorderRisk factorsPsychiatric symptomsPsychiatric disordersChoreaFeverNeuropsychiatric disordersObsessive-compulsive symptomsRating ScaleHyperactivity disorderSymptomsDisordersADHD symptomsChildrenSemistructured interviewsMarcador D8-17: implicações para a neuropsiquiatria
DINIZ J, DE ALVARENGA P, HOUNIE A, MIGUEL E. Marcador D8-17: implicações para a neuropsiquiatria. Arquivos De Neuro-Psiquiatria 2000, 58: 366-370. PMID: 10849643, DOI: 10.1590/s0004-282x2000000200028.Peer-Reviewed Original Research
1990
Neuropsychiatric disorders in systemic lupus erythematosus: a multidisciplinary review.
Miguel Filho E, Pereira R, de Almeida O, Hirsch R, Lafer B, Fang T, Busatto Filho G, de Arruda P. Neuropsychiatric disorders in systemic lupus erythematosus: a multidisciplinary review. Sao Paulo Medical Journal 1990, 108: 174-82. PMID: 2095621.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusLupus erythematosusClinical featuresNeuropsychiatric alterationsPsychiatric changesChronic diseasesDifferential diagnosisPsychic symptomsNeuropsychiatric disordersPatientsDiseaseDiagnosisMultidisciplinary reviewCorticosteroidsErythematosusHypertensionUremiaPathogenesisSymptomsInfection