2024
Chapter 21 Gamma Knife for psychiatric indications
Lopes A, de Arruda I, Batistuzzo M, Gorgulho A, de Salles A, Miguel E. Chapter 21 Gamma Knife for psychiatric indications. 2024, 495-517. DOI: 10.1016/b978-0-443-18496-3.00021-5.Peer-Reviewed Original ResearchAnorexia nervosaObsessive-compulsive disorder patientsTreatment of psychiatric disordersAnterior limb of internal capsuleObsessive-compulsive disorderVentral anterior limbGamma KnifeGK radiosurgeryMajor depressionDisorder patientsPsychiatric disordersPsychiatric indicationsNervosaDepressionInternal capsuleSurgical modalitiesAdverse eventsDisordersAnorexiaRadiosurgeryWeight gainManiaPsychiatryBrain cystsComplications
2023
Alterations in microRNA of extracellular vesicles associated with major depression, attention-deficit/hyperactivity and anxiety disorders in adolescents
Honorato-Mauer J, Xavier G, Ota V, Chehimi S, Mafra F, Cuóco C, Ito L, Ormond R, Asprino P, Oliveira A, Bugiga A, Torrecilhas A, Bressan R, Manfro G, Miguel E, Rohde L, Pan P, Salum G, Pellegrino R, Belangero S, Santoro M. Alterations in microRNA of extracellular vesicles associated with major depression, attention-deficit/hyperactivity and anxiety disorders in adolescents. Translational Psychiatry 2023, 13: 47. PMID: 36746925, PMCID: PMC9902559, DOI: 10.1038/s41398-023-02326-4.Peer-Reviewed Original ResearchConceptsMental health disordersCross-sectional analysisMajor depressive disorderAttention-deficit/hyperactivity disorderHealth disordersAnxiety disordersExtracellular vesiclesLarge ongoing cohort studiesMiR-432-5pPeripheral extracellular vesiclesTime pointsOngoing cohort studyMiR-328-3pSerum extracellular vesiclesLongitudinal analysisWave 2Deficit/hyperactivity disorderAdolescent participantsTotal extracellular vesiclesAttention-deficit/hyperactivityMiRNA expressionCohort studyDepressive disorderMajor depressionMiR-584-5p
2022
Taboo obsessions and their association with suicidality in obsessive-compulsive disorder
Cervin M, do Rosário M, Fontenelle L, Ferrão Y, Batistuzzo M, Torres A, Damiano R, Fernández de la Cruz L, Miguel E, Mataix-Cols D. Taboo obsessions and their association with suicidality in obsessive-compulsive disorder. Journal Of Psychiatric Research 2022, 154: 117-122. PMID: 35933855, DOI: 10.1016/j.jpsychires.2022.07.044.Peer-Reviewed Original Research
2019
SA72 GENE EXPRESSION IN BLOOD OF ADOLESCENTS WITH PSYCHIATRIC DISORDERS
Spindola L, Santoro M, Pan P, Talarico F, Xavier G, Carvalho C, Gadelha A, Salum G, Miguel E, Rohde L, Zanardo E, Kulikowski L, Bressan R, Ota V, Belangero S. SA72 GENE EXPRESSION IN BLOOD OF ADOLESCENTS WITH PSYCHIATRIC DISORDERS. European Neuropsychopharmacology 2019, 29: s861. DOI: 10.1016/j.euroneuro.2017.08.144.Peer-Reviewed Original ResearchHigh-risk cohortPsychiatric disordersHealthy controlsGene expression profilingChild Behavior ChecklistEarly-onset psychiatric disordersBlood of adolescentsPrevious psychiatric disorderBlood gene expression profilingCross-sectional studyOnset psychiatric disordersWell-Being AssessmentAttention deficit hyperactivity disorderMost psychiatric disordersCanonical pathwaysSchool-based studyLarge public healthExpression profilingDeficit hyperactivity disorderRisk cohortPrevalent diagnosisPD groupMajor depressionHC groupMultiple comparison correctionSU73 GENE EXPRESSION IN BLOOD OF ADOLESCENTS WITH PSYCHIATRIC DISORDERS
Spindola L, Santoro M, Pan P, Talarico F, Xavier G, Carvalho C, Gadelha A, Salum G, Miguel E, Rohde L, Zanardo E, Kulikowski L, Bressan R, Ota V, Belangero S. SU73 GENE EXPRESSION IN BLOOD OF ADOLESCENTS WITH PSYCHIATRIC DISORDERS. European Neuropsychopharmacology 2019, 29: s927-s928. DOI: 10.1016/j.euroneuro.2017.08.262.Peer-Reviewed Original ResearchHigh-risk cohortPsychiatric disordersHealthy controlsGene expression profilingChild Behavior ChecklistEarly-onset psychiatric disordersBlood of adolescentsPrevious psychiatric disorderBlood gene expression profilingCross-sectional studyOnset psychiatric disordersWell-Being AssessmentAttention deficit hyperactivity disorderMost psychiatric disordersCanonical pathwaysSchool-based studyLarge public healthExpression profilingDeficit hyperactivity disorderRisk cohortPrevalent diagnosisPD groupMajor depressionHC groupMultiple comparison correction
2017
Comorbidity, age of onset and suicidality in obsessive–compulsive disorder (OCD): An international collaboration
Brakoulias V, Starcevic V, Belloch A, Brown C, Ferrao Y, Fontenelle L, Lochner C, Marazziti D, Matsunaga H, Miguel E, Reddy Y, do Rosario M, Shavitt R, Sundar A, Stein D, Torres A, Viswasam K. Comorbidity, age of onset and suicidality in obsessive–compulsive disorder (OCD): An international collaboration. Comprehensive Psychiatry 2017, 76: 79-86. PMID: 28433854, DOI: 10.1016/j.comppsych.2017.04.002.Peer-Reviewed Original ResearchConceptsAge of onsetObsessive-compulsive disorderMajor depressive disorderComorbid disordersPsychiatric comorbidityAnxiety disordersSpecific phobiaDepressive disorderMajor depressionSuicidal ideationCo-occurring major depressive disorderLifetime psychiatric comorbiditySocial phobiaCurrent comorbid disordersPatterns of comorbidityComorbid major depressionPrimary obsessive-compulsive disorderDisorder treatment centersEarly ageBody dysmorphic disorderAdult patientsObsessive-compulsive personality disorderPsychiatric diagnostic classificationClinical variablesOCD comorbidity
2013
Panic Disorder and Agoraphobia in OCD patients: Clinical profile and possible treatment implications
Torres A, Ferrão Y, Shavitt R, Diniz J, Costa D, do Rosário M, Miguel E, Fontenelle L. Panic Disorder and Agoraphobia in OCD patients: Clinical profile and possible treatment implications. Comprehensive Psychiatry 2013, 55: 588-597. PMID: 24374170, DOI: 10.1016/j.comppsych.2013.11.017.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderPanic disorderClinical profileOCD patientsMajor depressionPrevalence of PDDSM-IV-TR Axis I DisordersCross-sectional studyAxis I DisordersStructured Clinical InterviewPD/agoraphobiaBrazilian Research ConsortiumLogistic regression modelsPosttraumatic stress disorderLarge clinical sampleYale-Brown ObsessiveComorbid conditionsPD comorbidityIndependent correlatesObsessive-compulsive spectrum disordersLifetime prevalenceTreatment strategiesI disordersStudy groupSeparation anxiety disorderCan early improvement be an indicator of treatment response in obsessive-compulsive disorder? Implications for early-treatment decision-making
da Conceição Costa D, Shavitt R, Cesar R, Joaquim M, Borcato S, Valério C, Miguel E, Diniz J. Can early improvement be an indicator of treatment response in obsessive-compulsive disorder? Implications for early-treatment decision-making. Journal Of Psychiatric Research 2013, 47: 1700-1707. PMID: 23948637, DOI: 10.1016/j.jpsychires.2013.07.006.Peer-Reviewed Original ResearchConceptsBaseline Y-BOCS scoresSerotonin reuptake inhibitorsEarly improvementTreatment responseY-BOCS scoresBaseline Yale-Brown ObsessiveLogistic regressionAdequate pharmacological treatmentPotential predictive factorsWeeks of treatmentGreater reductionObsessive-compulsive disorder patientsStepwise logistic regressionWarrants further investigationYale-Brown ObsessiveClinical featuresReuptake inhibitorsObsessive-compulsive disorderPharmacological treatmentPredictive factorsMajor depressionDisorder patientsOCD treatment responseCompulsive ScaleWeeksSymptom dimensions, clinical course and comorbidity in men and women with obsessive-compulsive disorder
Torresan R, Ramos-Cerqueira A, Shavitt R, do Rosário M, de Mathis M, Miguel E, Torres A. Symptom dimensions, clinical course and comorbidity in men and women with obsessive-compulsive disorder. Psychiatry Research 2013, 209: 186-195. PMID: 23298952, DOI: 10.1016/j.psychres.2012.12.006.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderClinical courseComorbid post-traumatic stress disorderDSM-IV Axis ICross-sectional studyStructured Clinical InterviewAlcohol use disorderSymptom dimensionsPost-traumatic stress disorderAdult OCD patientsBrazilian Research ConsortiumYale-Brown ObsessiveFemale patientsClinical presentationMean ageSymptom interferenceObsessive-compulsive spectrum disordersMajor depressionTic disordersFemale genderAxis IUse disordersClinical InterviewAnorexia nervosaSkin picking
2012
Does anti-obsessional pharmacotherapy treat so-called comorbid depressive and anxiety states?
Valerio C, Diniz J, Fossaluza V, de Mathis M, Belotto-Silva C, Joaquim M, Filho E, Shavitt R. Does anti-obsessional pharmacotherapy treat so-called comorbid depressive and anxiety states? Journal Of Affective Disorders 2012, 139: 187-192. PMID: 22455835, DOI: 10.1016/j.jad.2012.02.002.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderPsychiatric comorbidityTreatment responseOCD treatment responseTic disordersOCD treatmentAnxiety disordersOCD patientsNon-blinded studyAdditional psychiatric disordersCertain comorbid disordersPrimary obsessive-compulsive disorderCommon comorbiditiesAdult patientsComorbid conditionsComorbid depressiveChronic conditionsMajor depressionTreatment protocolComorbiditiesComorbid disordersPsychiatric disordersDisorders ProgramConventional treatmentPossible association
2011
Group cognitive-behavioral therapy versus selective serotonin reuptake inhibitors for obsessive-compulsive disorder: A practical clinical trial
Belotto-Silva C, Diniz J, Malavazzi D, Valério C, Fossaluza V, Borcato S, Seixas A, Morelli D, Miguel E, Shavitt R. Group cognitive-behavioral therapy versus selective serotonin reuptake inhibitors for obsessive-compulsive disorder: A practical clinical trial. Journal Of Anxiety Disorders 2011, 26: 25-31. PMID: 21907540, DOI: 10.1016/j.janxdis.2011.08.008.Peer-Reviewed Original ResearchConceptsGroup cognitive behavioral therapyY-BOCS scoresPsychiatric comorbidityCognitive behavioral therapySSRI groupMean Y-BOCS scoreSelective serotonin reuptake inhibitorsBaseline Y-BOCS scoresY-BOCS reductionSerotonin reuptake inhibitorsMore psychiatric comorbiditiesPractical clinical trialsReal-world populationObsessive-compulsive disorder outpatientsBroad inclusion criteriaAdditional psychiatric comorbidityReuptake inhibitorsObsessive-compulsive disorderClinical effectivenessClinical trialsMajor depressionCGI ratingsInclusion criteriaComorbiditiesWorse response
2010
Comorbid major depression in obsessive-compulsive disorder patients
Quarantini L, Torres A, Sampaio A, Fossaluza V, de Mathis M, do Rosário M, Fontenelle L, Ferrão Y, Cordioli A, Petribu K, Hounie A, Miguel E, Shavitt R, Koenen K. Comorbid major depression in obsessive-compulsive disorder patients. Comprehensive Psychiatry 2010, 52: 386-393. PMID: 21087765, DOI: 10.1016/j.comppsych.2010.09.006.Peer-Reviewed Original ResearchConceptsMajor depressive disorderObsessive-compulsive disorderOCD patientsCurrent major depressive disorderComorbid major depressive disorderLifetime major depressive disorderComprehensive psychiatric evaluationComorbid major depressionSevere general psychopathologyHigher severity scoresObsessive-compulsive disorder patientsSymptom dimensionsOCD symptom dimensionsClinical characteristicsFrequent complicationSeverity scoreDepressive disorderMajor depressionPrevalence ratesPsychiatric evaluationDisorder patientsPatientsGeneral psychopathologyDisordersOCD symptoms