Gene expression in blood of children and adolescents: Mediation between childhood maltreatment and major depressive disorder
Spindola L, Pan P, Moretti P, Ota V, Santoro M, Cogo-Moreira H, Gadelha A, Salum G, Manfro G, Mari J, Brentani H, Grassi-Oliveira R, Brietzke E, Miguel E, Rohde L, Sato J, Bressan R, Belangero S. Gene expression in blood of children and adolescents: Mediation between childhood maltreatment and major depressive disorder. Journal Of Psychiatric Research 2017, 92: 24-30. PMID: 28384542, DOI: 10.1016/j.jpsychires.2017.03.015.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentChildChild AbuseCohort StudiesDepressive Disorder, MajorFemaleGene ExpressionGenetic TestingHumansHypothalamo-Hypophyseal SystemInterleukin-1betaMaleModels, BiologicalPeptide FragmentsPituitary-Adrenal SystemReceptors, GlucocorticoidReceptors, Tumor Necrosis Factor, Type IResidence CharacteristicsRNA, MessengerTumor Necrosis Factor-alphaConceptsMajor depressive disorderBlood of childrenDepressive disorderChildhood maltreatmentMDD diagnosisRole of glucocorticoidsWhole blood mRNA levelsCM historyGene expressionAdrenal axisIllness exposureHealthy controlsDepressive symptomsMDD groupLarger studyMRNA expressionMRNA levelsExpression levelsInflammationTNFChildrenDiagnosisBloodAdolescentsNR3C1M31 Gene Expression In Blood of Children And Adolescents: Influence of Environmental Stressors On Major Depressive Disorder
Spindola L, Pan P, Moretti P, Ota V, Santoro M, Cogo-Moreira H, Gadelha A, Salum G, Manfro G, Mari J, Brentani H, Grassi-Oliveira R, Brietzke E, Miguel E, Rohde L, Sato J, Bressan R, Belangero S. M31 Gene Expression In Blood of Children And Adolescents: Influence of Environmental Stressors On Major Depressive Disorder. European Neuropsychopharmacology 2017, 27: s387-s388. DOI: 10.1016/j.euroneuro.2016.09.422.Peer-Reviewed Original ResearchMajor depressive disorderBlood of childrenPrenatal alcoholDepressive disorderChildhood maltreatmentMDD diagnosisPt exposureRole of glucocorticoidsPeripheral mRNA expressionGene expressionTobacco exposureIllness exposureHealthy controlsIL1B expressionDepressive symptomsMDD groupLarger studyMRNA expressionWhole bloodDisordersBloodExpression levelsInflammationTNFChildren