2020
Testing the Stability and Validity of an Executive Dysfunction Classification Using Task-Based Assessment in Children and Adolescents
Manfro A, Pine D, Polanczyk G, Santoro M, Smoller J, Koenen K, Mari J, Pan P, Zugman A, Schäfer J, Belangero S, Gosmann N, Simioni A, Hoexter M, Miguel E, Gadelha A, Rohde L, Salum G. Testing the Stability and Validity of an Executive Dysfunction Classification Using Task-Based Assessment in Children and Adolescents. Journal Of The American Academy Of Child & Adolescent Psychiatry 2020, 60: 1501-1512. PMID: 33346031, PMCID: PMC10259767, DOI: 10.1016/j.jaac.2020.11.016.Peer-Reviewed Original ResearchConceptsPolygenic risk scoresPsychiatric diagnosisExecutive functionHigher schizophrenia polygenic risk scoresExecutive dysfunctionHigh Risk Cohort StudySmaller intracranial volumeHigher attention-deficit/hyperactivity disorderAttention-deficit/hyperactivity disorderSchizophrenia polygenic risk scoresCortical surface areaDichotomized ageCohort studyFunctional impairmentRisk scoreDomains of psychopathologyBrain regionsIntracranial volumeRelevant outcomesBrain structuresHyperactivity disorderCognitive tasksLatent class analysisLower chanceDiagnosis
2015
Reduced Prefrontal Activation in Pediatric Patients With Obsessive-Compulsive Disorder During Verbal Episodic Memory Encoding
Batistuzzo M, Balardin J, da Graça Morais Martin M, Hoexter M, Bernardes E, Borcato S, de Marco e Souza M, Querido C, Morais R, de Alvarenga P, Lopes A, Shavitt R, Savage C, Amaro E, Miguel E, Polanczyk G, Miotto E. Reduced Prefrontal Activation in Pediatric Patients With Obsessive-Compulsive Disorder During Verbal Episodic Memory Encoding. Journal Of The American Academy Of Child & Adolescent Psychiatry 2015, 54: 849-858. PMID: 26407495, DOI: 10.1016/j.jaac.2015.06.020.Peer-Reviewed Original ResearchConceptsVerbal episodic memoryObsessive-compulsive disorderEpisodic memoryOrbitofrontal cortexPrefrontal cortexSemantic clusteringFunctional magnetic resonance imagingDorsomedial prefrontal cortexAltered brain activationDifferent neural mechanismsPathophysiology of OCDUnrelated wordsPrefrontal activationBrain activationWord listsExecutive dysfunctionNeural mechanismsTotal wordsCompulsive Scale scoresYale-Brown Obsessive Compulsive Scale scoresStrategy scoresStrategy applicationMemoryCortexKey regions