2004
Effectiveness Over Time of Varicella Vaccine
Vázquez M, LaRussa PS, Gershon AA, Niccolai LM, Muehlenbein CE, Steinberg SP, Shapiro ED. Effectiveness Over Time of Varicella Vaccine. JAMA 2004, 291: 851-855. PMID: 14970064, DOI: 10.1001/jama.291.7.851.Peer-Reviewed Original ResearchConceptsTime of vaccinationVaricella vaccineVaccine effectivenessCase subjectsPolymerase chain reaction test resultsVaricella-zoster virus DNACase-control studyReaction test resultsReports of outbreaksFirst yearBreakthrough diseaseImmunized groupsActive surveillancePossible confoundersPediatric practiceVaccinationVaccineVirus DNAMonthsMost casesGroup practiceChickenpoxAgeYear 2Year 1
2001
The Effectiveness of the Varicella Vaccine in Clinical Practice
Vázquez M, LaRussa P, Gershon A, Steinberg S, Freudigman K, Shapiro E. The Effectiveness of the Varicella Vaccine in Clinical Practice. New England Journal Of Medicine 2001, 344: 955-960. PMID: 11274621, DOI: 10.1056/nejm200103293441302.Peer-Reviewed Original ResearchConceptsVaricella-zoster virusVaricella vaccinePolymerase chain reactionMild diseasePediatric practiceClinical practicePositive PCR testCase-control studyConditional logistic regressionPotential casesUnvaccinated childrenPotential confoundersActive surveillanceSevere diseaseChickenpoxDay 3VaccineLogistic regressionPCR testDiseaseChain reactionChildrenResearch assistantsIllnessVirus
2000
Varicella vaccine revisited
LaRussa P, Steinberg S, Shapiro E, Vazquez M, Gershon A. Varicella vaccine revisited. Nature Medicine 2000, 6: 1299-1299. PMID: 11100089, DOI: 10.1038/82070.Commentaries, Editorials and LettersGroup-Specific Antibody Levels Surrounding Invasive Pneumococcal Illness in Children Infected with Human Immunodeficiency Virus
King J, Borkowsky W, Mahidhara N, Madore D, Shapiro E, Rutstein R, Tan T, Farley J, Dankner W, Nachman S, Simoes E, Flynn P, Clemens J, Hamilton R. Group-Specific Antibody Levels Surrounding Invasive Pneumococcal Illness in Children Infected with Human Immunodeficiency Virus. The Journal Of Infectious Diseases 2000, 181: 1817-1821. PMID: 10823792, DOI: 10.1086/315441.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusAntibody levelsSerum samplesPneumococcal illnessImmunodeficiency virusPneumococcal antibody levelsGeometric mean levelsAntibody valuesPneumococcal serotypesIgG antibodiesGroup 4Mean levelsSeroresponsesIllnessChildrenWeeksSerotypesVirusLevelsSerorespondersELISAAntibodies
1998
Lyme Arthritis in Children: Clinical Epidemiology and Long-term Outcomes
Gerber M, Zemel L, Shapiro E. Lyme Arthritis in Children: Clinical Epidemiology and Long-term Outcomes. Pediatrics 1998, 102: 905-908. PMID: 9755263, DOI: 10.1542/peds.102.4.905.Peer-Reviewed Original ResearchConceptsLong-term outcomesLyme arthritisAppropriate antimicrobial therapyAntimicrobial therapyClinical epidemiologyLyme diseaseMean white blood cell countWhite blood cell countNewington Children's HospitalCells/mm3Pediatric rheumatology clinicTime of diagnosisEarly Lyme diseaseErythrocyte sedimentation rateLong-term followOnset of symptomsBlood cell countStructured telephone interviewActive arthritisChronic arthritisRheumatology clinicArthroscopic synovectomyInitial diagnosisChildren's HospitalTelephone followLyme Disease
Shapiro E. Lyme Disease. Pediatrics In Review 1998, 19: 147-154. PMID: 9584524, DOI: 10.1542/pir.19-5-147.Peer-Reviewed Original Research
1997
Vaccination for varicella--just do it!
Shapiro E, LaRussa P. Vaccination for varicella--just do it! JAMA 1997, 278: 1529-30. PMID: 9363975, DOI: 10.1001/jama.278.18.1529.Commentaries, Editorials and LettersVaccination for Varicella—Just Do It!
Shapiro E, LaRussa P. Vaccination for Varicella—Just Do It! JAMA 1997, 278: 1529-1530. DOI: 10.1001/jama.1997.03550180079042.Commentaries, Editorials and LettersConceptsVaricella vaccineVaccine-induced immunity wanesStrategy of immunizationDuration of protectionMonths of agePublic health servicesImmune childrenImmunization PracticesImmunity wanesUS FoodDrug AdministrationSusceptible adultsSusceptible individualsInfants 12Health servicesAmerican AcademyInfectious diseasesVaccineVaricellaAdvisory CommitteeAdultsConsiderable controversyChildrenVaccineesMorbidityLyme Disease in Children
Shapiro E, Seltzer E. Lyme Disease in Children. Seminars In Neurology 1997, 17: 39-44. PMID: 9166958, DOI: 10.1055/s-2008-1040911.ChaptersFever without apparent source on clinical examination, Lower respiratory infections in children, Other infectious diseases, and Acute gastroenteritis and diarrhea of infancy and early childhood
McCarthy P, Klig J, Kahn J, Shapiro E, Baron M. Fever without apparent source on clinical examination, Lower respiratory infections in children, Other infectious diseases, and Acute gastroenteritis and diarrhea of infancy and early childhood. Current Opinion In Pediatrics 1997, 9: 105-126. PMID: 9088764, DOI: 10.1097/00008480-199702000-00021.Commentaries, Editorials and LettersConceptsDiarrhea of infancyInfectious diseasesClinical examinationLower respiratory tract infectionsRespiratory tract infectionsPediatric office practiceEvaluation of childrenEarly childhoodProlonged feverTract infectionsAcute feverRespiratory infectionsAcute gastroenteritisUnknown originOffice settingOffice practiceDiseaseRecent literatureApparent sourceDiarrheaFeverEugene ShapiroChildrenGastroenteritisInfection
1996
Lyme Disease in Children in Southeastern Connecticut
Gerber M, Shapiro E, Burke G, Parcells V, Bell G. Lyme Disease in Children in Southeastern Connecticut. New England Journal Of Medicine 1996, 335: 1270-1274. PMID: 8857006, DOI: 10.1056/nejm199610243351703.Peer-Reviewed Original ResearchConceptsErythema migrans lesionsSingle erythema migrans lesionLyme diseaseErythema migransClinical manifestationsMultiple erythema migrans lesionsCommunity-based cohort studyFacial nerve palsyInitial clinical manifestationPrompt clinical responseEarly Lyme diseasePercent of childrenConventional antimicrobial therapyMultiple erythemaClinical responseCohort studyAseptic meningitisConsecutive patientsMedian ageProspective dataAntimicrobial therapyAntibody testNew episodesPatientsLesionsFever without apparent source on clinical examination, Lower respiratory infections in children, Other infectious diseases, and Acute gastroenteritis and diarrhea of infancy and early childhood
McCarthy P, Klig J, Shapiro E, Baron M. Fever without apparent source on clinical examination, Lower respiratory infections in children, Other infectious diseases, and Acute gastroenteritis and diarrhea of infancy and early childhood. Current Opinion In Pediatrics 1996, 8: 75-93. PMID: 8680522, DOI: 10.1097/00008480-199602000-00017.Commentaries, Editorials and LettersConceptsDiarrhea of infancyInfectious diseasesClinical examinationLower respiratory tract infectionsRespiratory tract infectionsPediatric office practiceEvaluation of childrenEarly childhoodProlonged feverTract infectionsAcute feverRespiratory infectionsAcute gastroenteritisUnknown originOffice practiceDiseaseRecent literatureApparent sourceDiarrheaFeverEugene ShapiroChildrenGastroenteritisInfectionChildhood
1995
Office pediatrics
McCarthy P, Bachman D, Shapiro E, Baron M. Office pediatrics. Current Opinion In Pediatrics 1995, 7: 107-125. PMID: 7728195, DOI: 10.1097/00008480-199502000-00020.Commentaries, Editorials and LettersConceptsCommunity-acquired lower respiratory infectionsLower respiratory tract infectionsInfectious diseasesDiarrhea of infancyLower respiratory infectionsRespiratory tract infectionsPediatric office practiceRespiratory syncytial virusHemolytic uremic syndromeEvaluation of childrenDay care centersProlonged feverTract infectionsAcute feverRespiratory infectionsSyncytial virusClinical examinationCare centerEnterohemorrhagic Escherichia coliStreptococcus pneumoniaeUnknown originOffice settingOffice practiceInfectionAntimicrobial drugs
1994
Fever without apparent source on clinical examination, Lower respiratory infections in children, Bacterial infections, and Acute gastroenteritis and diarrhea of infancy and early childhood
McCarthy P, Bachman D, Shapiro E, Baron M. Fever without apparent source on clinical examination, Lower respiratory infections in children, Bacterial infections, and Acute gastroenteritis and diarrhea of infancy and early childhood. Current Opinion In Pediatrics 1994, 6: 105. PMID: 8205167, DOI: 10.1097/00008480-199402000-00019.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsDiarrhea of infancyClinical examinationRespiratory syncytial virus infectionLower respiratory tract infectionsInfectious diseasesHaemophilus influenzae type bSyncytial virus infectionRespiratory tract infectionsMycobacterium tuberculosis infectionPediatric office practiceCat-scratch diseaseInfluenzae type bEvaluation of childrenEarly childhoodProlonged feverAspiration pneumoniaStreptococcal pharyngitisTract infectionsAcute feverRespiratory infectionsTuberculosis infectionChlamydia infectionOtitis mediaTherapeutic advancesAcute gastroenteritis
1992
A Controlled Trial of Antimicrobial Prophylaxis for Lyme Disease after Deer-Tick Bites
Shapiro E, Gerber M, Holabird N, Berg A, Feder H, Bell G, Rys P, Persing D. A Controlled Trial of Antimicrobial Prophylaxis for Lyme Disease after Deer-Tick Bites. New England Journal Of Medicine 1992, 327: 1769-1773. PMID: 1435930, DOI: 10.1056/nejm199212173272501.Peer-Reviewed Original ResearchConceptsDeer tick biteRisk of infectionProphylactic antimicrobial treatmentLyme diseaseB. burgdorferiAntimicrobial treatmentDeer ticksPlacebo-controlled trialPlacebo-treated subjectsCare of personsAsymptomatic seroconversionAntimicrobial prophylaxisErythema migransClinical manifestationsPolymerase chain reactionLate manifestationPlaceboDiseaseSerum samplesInfectionBorrelia burgdorferiBiteChain reactionAmoxicillinBurgdorferiA Prospective Study of Recurrent Febrile Seizures
Berg A, Shinnar S, Hauser W, Alemany M, Shapiro E, Salomon M, Crain E. A Prospective Study of Recurrent Febrile Seizures. New England Journal Of Medicine 1992, 327: 1122-1127. PMID: 1528207, DOI: 10.1056/nejm199210153271603.Peer-Reviewed Original ResearchConceptsRisk of recurrenceRecurrent febrile seizuresFebrile seizuresProspective studyFamily historyFirst febrile seizureDuration of feverPredictors of recurrenceComplex febrile seizuresInitial febrile seizurePediatric emergency departmentInitial seizureEmergency departmentMedical recordsNeurodevelopmental abnormalitiesCumulative riskRecurrenceFeverSeizuresDegree of increaseDegrees FChildrenRiskShort durationMonthsOutcome of children with occult bacteremia caused by Haemophilus influenzae type b
KORONES D, MARSHALL G, SHAPIRO E. Outcome of children with occult bacteremia caused by Haemophilus influenzae type b. The Pediatric Infectious Disease Journal 1992, 11: 516-520. PMID: 1528640, DOI: 10.1097/00006454-199207000-00002.Peer-Reviewed Original ResearchConceptsHaemophilus influenzae type bOutcome of childrenInfluenzae type bOccult bacteremiaHib bacteremiaYale-New Haven HospitalSerious focal infectionsType BClinical courseMedian ageHib infectionsChildren's HospitalSerious infectionsHealthy childrenMedical recordsFocal infectionBacteremiaHospitalInfectionChildrenOutpatientsSuch antimicrobialsOutcomesBetter definitionAntimicrobialsDiagnosis of Lyme disease in children
Gerber M, Shapiro E. Diagnosis of Lyme disease in children. The Journal Of Pediatrics 1992, 121: 157-162. PMID: 1625075, DOI: 10.1016/s0022-3476(05)82569-7.Peer-Reviewed Original Research
1990
New Vaccines Against Haemophilus Influenzae Type b
Shapiro E. New Vaccines Against Haemophilus Influenzae Type b. Pediatric Clinics Of North America 1990, 37: 567-583. PMID: 2190140, DOI: 10.1016/s0031-3955(16)36905-x.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsProtective efficacy of Haemophilus influenzae type b polysaccharide vaccine.
Shapiro E, Berg A. Protective efficacy of Haemophilus influenzae type b polysaccharide vaccine. Pediatrics 1990, 85: 643-7. PMID: 2179854, DOI: 10.1542/peds.85.4.643.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsType b polysaccharide vaccineH influenzae type b polysaccharide vaccineHaemophilus influenzae type b polysaccharide vaccinePolysaccharide vaccineProtective efficacyMonths of ageVaccine failureInvasive diseaseH influenzae type b.Immunization Practices Advisory CommitteeH influenzae type bVaccine protective efficacyRandomized clinical trialsInfluenzae type bAvailable epidemiologic dataNormal serum concentrationsYears of ageTotal immunoglobulinSerum concentrationsImmune deficiencyClinical trialsEpidemiologic dataHemolytic complementVaccineChildren 18