1999
ANTIBODIES TO GRANULOCYTIC EHRLICHIAE IN WHITE-FOOTED AND COTTON MICE IN EASTERN UNITED STATES
Magnarelli L, Stafford K, IJdo J, Fikrig E, Oliver J, Hutcheson H, Boone J. ANTIBODIES TO GRANULOCYTIC EHRLICHIAE IN WHITE-FOOTED AND COTTON MICE IN EASTERN UNITED STATES. Journal Of Wildlife Diseases 1999, 35: 259-265. PMID: 10231752, DOI: 10.7589/0090-3558-35.2.259.Peer-Reviewed Original ResearchConceptsIndirect fluorescent antibodyNCH-1 strainHuman granulocytic ehrlichiosis (HGE) agentGranulocytic ehrlichiaeWestern blot analysisP. gossypinusSerologic assaysImmune responseWestern blot procedureEtiologic agentMouse serumSurveillance programSerum samplesMiceSerumAntibodiesEndemic sitesFluorescent antibodyBlot analysisWhite-footed miceIFA methodTitersEhrlichiaeP. leucopusAmelia IslandInfluence of Outer Surface Protein A Antibody onBorrelia burgdorferi within Feeding Ticks
de Silva A, Zeidner N, Zhang Y, Dolan M, Piesman J, Fikrig E. Influence of Outer Surface Protein A Antibody onBorrelia burgdorferi within Feeding Ticks. Infection And Immunity 1999, 67: 30-35. PMID: 9864192, PMCID: PMC96273, DOI: 10.1128/iai.67.1.30-35.1999.Peer-Reviewed Original ResearchConceptsAntibody levelsSalivary glandsAntibody titersOspA antibodiesBorrelia burgdorferiLow antibody levelsNumber of spirochetesDensity of spirochetesEnzyme-linked immunosorbentFeeding ticksSurface protein AAbility of spirochetesOuter surface protein AProtective epitopesCompetitive enzyme-linked immunosorbentOuter surface proteinsSpirochetal agentLyme diseaseAntibodiesB. burgdorferiTitersIxodes ticksGlandBurgdorferiSpirochetes
1997
Borrelia burgdorferi P35 and P37 Proteins, Expressed In Vivo, Elicit Protective Immunity
Fikrig E, Barthold S, Sun W, Feng W, Telford S, Flavell R. Borrelia burgdorferi P35 and P37 Proteins, Expressed In Vivo, Elicit Protective Immunity. Immunity 1997, 6: 531-539. PMID: 9175831, DOI: 10.1016/s1074-7613(00)80341-6.Peer-Reviewed Original ResearchConceptsElicit protective immunityB. burgdorferiIgG titersProtective immunityInfected miceImmune responseHost immunityLyme borreliosisRT-PCR analysisMiceVivo-expressed antigensBorrelia burgdorferi genesImmunityP35BurgdorferiP37 proteinVivoNorthern blotAntiserumP37PatientsAntigenELISATitersBorreliosis
1995
Oral vaccination with an attenuated Salmonella typhimurium strain expressing Borrelia burgdorferi OspA prevents murine Lyme borreliosis
Dunne M, al-Ramadi BK, Barthold SW, Flavell RA, Fikrig E. Oral vaccination with an attenuated Salmonella typhimurium strain expressing Borrelia burgdorferi OspA prevents murine Lyme borreliosis. Infection And Immunity 1995, 63: 1611-1614. PMID: 7890431, PMCID: PMC173199, DOI: 10.1128/iai.63.4.1611-1614.1995.Peer-Reviewed Original ResearchConceptsAnti-OspA antibodyMurine Lyme borreliosisDevelopment of antibodiesMajor outer surface proteinsSalmonella typhimurium strainsOral vaccinationIntradermal challengeMouse modelAttenuated strainOuter surface proteinsHigh titersLyme borreliosisLyme diseaseBorrelia burgdorferiTyphimurium strainsCausative agentDiseaseAntibodiesSurface proteinsSalmonella typhimuriumGavageVaccinationMiceTitersBorreliosis