2021
AgBR1 and NeSt1 antisera protect mice from Aedes aegypti-borne Zika infection
Marin-Lopez A, Wang Y, Jiang J, Ledizet M, Fikrig E. AgBR1 and NeSt1 antisera protect mice from Aedes aegypti-borne Zika infection. Vaccine 2021, 39: 1675-1679. PMID: 33622591, PMCID: PMC7990057, DOI: 10.1016/j.vaccine.2021.01.072.Peer-Reviewed Original ResearchConceptsMosquito saliva proteinsPassive immunizationZIKV infectionEarly host responseDiverse clinical symptomsViral burdenSaliva proteinsClinical symptomsVaccine strategiesZika infectionHost responseModel antigenInfectionPartial protectionMiceImmunizationZIKVAntiserumIndividual antiseraAgBR1ViremiaSymptomsAntigenBloodAntibodies
2020
TRiC/CCT Complex, a Binding Partner of NS1 Protein, Supports the Replication of Zika Virus in Both Mammalians and Mosquitoes
Wang Y, Uraki R, Hwang J, Fikrig E. TRiC/CCT Complex, a Binding Partner of NS1 Protein, Supports the Replication of Zika Virus in Both Mammalians and Mosquitoes. Viruses 2020, 12: 519. PMID: 32397176, PMCID: PMC7290343, DOI: 10.3390/v12050519.Peer-Reviewed Original ResearchConceptsZika virusZIKV replicationZIKV NS1 proteinGuillain-Barré syndromeNS1 proteinTRiC/CCT complexPromising therapeutic targetZIKV infectionCongenital microcephalySpecific treatmentTherapeutic targetHost factorsVirusMosquitoesSyndromeVaccineSymptomsInfectionMicrocephalyProteinReplicationImportant role
1994
A Recombinant OspA and OspB Based Lyme Disease Vaccine
Fikrig E, Kantor F, Barthold S, Flavell R. A Recombinant OspA and OspB Based Lyme Disease Vaccine. NATO Science Series A: 1994, 25-31. DOI: 10.1007/978-1-4615-2415-1_5.Peer-Reviewed Original Research
1989
Septic Shock and Acute Respiratory Distress Syndrome After Salpingitis Caused by Streptococcus pyogenes Group A
FIKRIG E, WORTHINGTON M, LEFKOWITZ L. Septic Shock and Acute Respiratory Distress Syndrome After Salpingitis Caused by Streptococcus pyogenes Group A. Southern Medical Journal 1989, 82: 634-635. PMID: 2655106, DOI: 10.1097/00007611-198905000-00024.Peer-Reviewed Original ResearchConceptsAcute respiratory distress syndromeRespiratory distress syndromeStreptococcus pyogenes group ADistress syndromeGroup AIntensive supportive therapySymptoms of sepsisOnset of illnessIntravascular coagulationRenal failureAcute salpingitisSeptic shockSupportive therapyBlood culturesSalpingitisSyndromeHypotensionLaparotomySepsisPatientsTherapyIllnessSymptomsWomen