1997
Protective antibodies develop, and murine Lyme arthritis regresses, in the absence of MHC class II and CD4+ T cells.
Fikrig E, Barthold SW, Chen M, Chang CH, Flavell RA. Protective antibodies develop, and murine Lyme arthritis regresses, in the absence of MHC class II and CD4+ T cells. The Journal Of Immunology 1997, 159: 5682-6. PMID: 9548512, DOI: 10.4049/jimmunol.159.11.5682.Peer-Reviewed Original ResearchConceptsMHC class IIT cellsClass IINaive C3H/HeN miceC3H/HeN miceC57/BL6 miceCIITA-deficient miceRegression of arthritisResolution of arthritisResolution of carditisDevelopment of arthritisMurine Lyme borreliosisMHC class II transactivatorClass II moleculesClass II transactivatorIgG2b AbsProtective antibodiesBL6 miceHeN miceDeficient miceProtective AbsSCID micePersistent infectionArthritisCD4 repertoire
1996
Protective antibodies in murine Lyme disease arise independently of CD40 ligand.
Fikrig E, Barthold SW, Chen M, Grewal IS, Craft J, Flavell RA. Protective antibodies in murine Lyme disease arise independently of CD40 ligand. The Journal Of Immunology 1996, 157: 1-3. PMID: 8683101, DOI: 10.4049/jimmunol.157.1.1.Peer-Reviewed Original ResearchConceptsCD40L-deficient miceCD40 ligand-deficient miceMurine Lyme diseaseRegression of arthritisTransfer of serumDependent immune responsesIgG2b AbsAcute arthritisControl miceProtective antibodiesIg class switchingCD40 ligandImmune responseImmunodeficient miceLyme borreliosisLyme diseaseMiceBorrelia burgdorferiB. burgdorferiClass switchingArthritisBurgdorferiAbInfectionDisease
1995
Lyme borreliosis in transgenic mice tolerant to Borrelia burgdorferi OspA or B.
Fikrig E, Tao H, Chen M, Barthold SW, Flavell RA. Lyme borreliosis in transgenic mice tolerant to Borrelia burgdorferi OspA or B. Journal Of Clinical Investigation 1995, 96: 1706-1714. PMID: 7560061, PMCID: PMC185806, DOI: 10.1172/jci118215.Peer-Reviewed Original ResearchConceptsC3H/HeJTransgenic miceLyme borreliosisImmune responseB. burgdorferi-specific antibodyLyme diseaseMajor histocompatibility complex class IBurgdorferi-specific antibodiesRegression of arthritisCellular immune responsesDevelopment of arthritisHistocompatibility complex class IRole of immunityB. burgdorferi antigensComplex class ISurface protein ABorrelia burgdorferi outer surface protein AOuter surface protein ATolerant miceNontransgenic littermatesB6 miceSCID miceImmunodeficient miceB antibodiesC57BL/6 background