2024
Multicenter automated central vein sign detection performs as well as manual assessment for the diagnosis of multiple sclerosis.
Manning A, Letchuman V, Martin M, Gombos E, Roberts-Fitzgerald T, Cao Q, Raza P, O'Donnell C, Renner B, Daboul L, Rodrigues P, Ramos M, Derbyshire J, Azevedo C, Bar-Or A, Caverzasi E, Calabresi P, Cree B, Freeman L, Henry R, Longbrake E, Oh J, Papinutto N, Pelletier D, Samudralwar R, Suthiphosuwan S, Schindler M, Bilello M, Song J, Sotirchos E, Sicotte N, Al-Louzi O, Solomon A, Reich D, Ontaneda D, Sati P, Shinohara R. Multicenter automated central vein sign detection performs as well as manual assessment for the diagnosis of multiple sclerosis. American Journal Of Neuroradiology 2024 PMID: 39332906, DOI: 10.3174/ajnr.a8510.Peer-Reviewed Original ResearchCentral vein signCVS+ lesionsWhite matter lesionsMultiple sclerosisMulticenter studyProportions of white matter lesionsSuspicion of MSReceiver-operating characteristic curveFluid-attenuated inversion recoveryDiagnosis of multiple sclerosisDiagnosis of MSMagnetic resonance imagingAtypical clinical syndromeRadiological mimicsClinical syndromeDiagnostic imaging biomarkersManual assessmentT MRIClinical implementationImaging biomarkersLesionsInversion recoveryResonance imagingCharacteristic curveInter-rater reliability
2023
Anti-CRMP5 optic neuropathy associated with oral squamous cell carcinoma
Nulton C, Longbrake E, Alkawadri R, Alkawadri C. Anti-CRMP5 optic neuropathy associated with oral squamous cell carcinoma. Neuroimmunology Reports 2023, 3: 100170. DOI: 10.1016/j.nerep.2023.100170.Peer-Reviewed Original ResearchSquamous cell carcinomaParaneoplastic optic neuropathyOptic neuropathyCell carcinomaMagnetic resonance imagingVisual lossDifferential diagnosisHigh-dose intravenous corticosteroidsBilateral optic disc edemaSmall cell lung cancerOral squamous cell carcinomaPositron emission tomography scanNegative infectious workupOptic disc edemaCervical lymph nodesCerebrospinal fluid analysisEmission tomography scanPainless visual lossFirst case reportAntibody elevationDisc edemaInfectious workupIntravenous corticosteroidsOptic neuritisParaneoplastic etiology
2016
Effect of Multiple Sclerosis Disease-Modifying Therapies on B Cells and Humoral Immunity
Longbrake EE, Cross AH. Effect of Multiple Sclerosis Disease-Modifying Therapies on B Cells and Humoral Immunity. JAMA Neurology 2016, 73: 1-7. PMID: 26720195, DOI: 10.1001/jamaneurol.2015.3977.Peer-Reviewed Original ResearchConceptsDisease-modifying therapiesB cell immunityB cellsMultiple sclerosisAnti-inflammatory cytokine interleukin-10B-cell-depleting agentsMultiple Sclerosis Disease-Modifying TherapiesMost disease-modifying therapiesCytokine interleukin-10Memory B cellsB cell functionB-cell phenotypeB cell expressionB cell productionNaive B cellsMagnetic resonance imagingB cell precursorsClinical courseTherapeutic trialsInterleukin-10Proinflammatory cytokinesHumoral immunityClinical activityTherapeutic interventionsResonance imaging