Eriko Yasumizu, MD
Associate Research ScientistAbout
Research
Publications
2025
Single-nucleus multiome shows motor neuron glutamate overactivation in amyotrophic lateral sclerosis
Takeuchi E, Yasumizu Y, Morita J, Ishikawa M, Ogawa K, Motooka D, Okuzaki D, Nagata M, Ishihara Y, Miyashita Y, Asano Y, Mori K, Morii E, Beck G, Saito Y, Murayama S, Mochizuki H, Nagano S. Single-nucleus multiome shows motor neuron glutamate overactivation in amyotrophic lateral sclerosis. Brain 2025, awaf426. PMID: 41218062, DOI: 10.1093/brain/awaf426.Peer-Reviewed Original ResearchSpinal motor neuronsAmyotrophic lateral sclerosis pathologyGenome-wide association study dataCell type-specific enrichmentAmyotrophic lateral sclerosisMotor neuronsChromatin accessibility profilesGlutamate signalingVulnerability of motor neuronsMetabotropic glutamate receptorsRegulatory regionsMotor neuron degenerationRNA sequencingMultiomics analysisLateral sclerosisGene expressionAccessibility profilesPotential therapeutic targetGlutamate receptorsNeuronal cellsSpinal cordNeurodegenerative diseasesNeuronal degenerationCellular levelTherapeutic target