Featured Publications
Estimation of ascertainment bias and its effect on power in clinical trials with time‐to‐event outcomes
Greene EJ, Peduzzi P, Dziura J, Meng C, Miller ME, Travison TG, Esserman D. Estimation of ascertainment bias and its effect on power in clinical trials with time‐to‐event outcomes. Statistics In Medicine 2020, 40: 1306-1320. PMID: 33316841, PMCID: PMC9007163, DOI: 10.1002/sim.8842.Peer-Reviewed Original ResearchA Randomized Trial of a Multifactorial Strategy to Prevent Serious Fall Injuries
Bhasin S, Gill TM, Reuben DB, Latham NK, Ganz DA, Greene EJ, Dziura J, Basaria S, Gurwitz JH, Dykes PC, McMahon S, Storer TW, Gazarian P, Miller ME, Travison TG, Esserman D, Carnie MB, Goehring L, Fagan M, Greenspan SL, Alexander N, Wiggins J, Ko F, Siu AL, Volpi E, Wu AW, Rich J, Waring SC, Wallace RB, Casteel C, Resnick NM, Magaziner J, Charpentier P, Lu C, Araujo K, Rajeevan H, Meng C, Allore H, Brawley BF, Eder R, McGloin JM, Skokos EA, Duncan PW, Baker D, Boult C, Correa-de-Araujo R, Peduzzi P. A Randomized Trial of a Multifactorial Strategy to Prevent Serious Fall Injuries. New England Journal Of Medicine 2020, 383: 129-140. PMID: 32640131, PMCID: PMC7421468, DOI: 10.1056/nejmoa2002183.Peer-Reviewed Original ResearchConceptsSerious fall injuriesFall injuriesIntervention groupControl groupUsual careMultifactorial interventionRate of hospitalizationPrimary care practicesCluster-randomized trialCommunity-dwelling adultsFirst-event analysisYears of ageHealth care systemRate of fallElectronic health recordsBaseline characteristicsPrimary outcomeRandomized trialsMean ageEfficacy trialsIndividualized planCare practicesInjuryMultifactorial strategyEvent rates
2022
Effect of the STRIDE fall injury prevention intervention on falls, fall injuries, and health‐related quality of life
Ganz DA, Yuan AH, Greene EJ, Latham NK, Araujo K, Siu AL, Magaziner J, Gurwitz JH, Wu AW, Alexander NB, Wallace RB, Greenspan SL, Rich J, Volpi E, Waring SC, Dykes PC, Ko F, Resnick NM, McMahon SK, Basaria S, Wang R, Lu C, Esserman D, Dziura J, Miller ME, Travison TG, Peduzzi P, Bhasin S, Reuben DB, Gill TM. Effect of the STRIDE fall injury prevention intervention on falls, fall injuries, and health‐related quality of life. Journal Of The American Geriatrics Society 2022, 70: 3221-3229. PMID: 35932279, PMCID: PMC9669115, DOI: 10.1111/jgs.17964.Peer-Reviewed Original ResearchConceptsHealth-related qualityHospital admissionEQ-5DMedical attentionLeast square mean changeFall injury riskSelf-reported fracturesFall-related fracturesFall-related outcomesIncidence rate ratiosInjury prevention interventionsPrimary care practicesReal-world effectivenessFall prevention studiesMeaningful clinical effectsGOV IDENTIFIERUsual careMultifactorial interventionClinical effectsEQ-VASPrevention StudyFall injuriesOlder adults ageMean changePrevention interventionsEngagement of older adults in STRIDE's multifactorial fall injury prevention intervention
McMahon SK, Greene EJ, Latham N, Peduzzi P, Gill TM, Bhasin S, Reuben DB. Engagement of older adults in STRIDE's multifactorial fall injury prevention intervention. Journal Of The American Geriatrics Society 2022, 70: 3116-3126. PMID: 35924574, PMCID: PMC9669158, DOI: 10.1111/jgs.17983.Peer-Reviewed Original ResearchConceptsMultifactorial fall prevention interventionFall prevention interventionsFall risk factorsPrevention interventionsRisk factorsOlder adultsFall prevention carePatient-clinician partnershipsInjury prevention interventionsPrevention actionsOlder adults' engagementPrevention careHome exercisesPragmatic trialCare levelCare plansParticipant engagementClinical practicePredictors of engagementInterventionAdultsMore participantsCliniciansFrequent contactAdults' engagement
2021
A case study of ascertainment bias for the primary outcome in the Strategies to Reduce Injuries and Develop Confidence in Elders (STRIDE) trial
Esserman DA, Gill TM, Miller ME, Greene EJ, Dziura JD, Travison TG, Meng C, Peduzzi PN. A case study of ascertainment bias for the primary outcome in the Strategies to Reduce Injuries and Develop Confidence in Elders (STRIDE) trial. Clinical Trials 2021, 18: 207-214. PMID: 33678038, PMCID: PMC8009806, DOI: 10.1177/1740774520980070.Peer-Reviewed Original ResearchConceptsPrimary outcome definitionUsual care armSerious fall injuriesMedical attentionOutcome definitionsFall injuriesElders trialCare armOvernight hospitalizationStudy powerCare managersIntervention effectsType 2 injuriesAscertainment biasAscertainment of outcomesInterim monitoring planUsual careHazard ratioPrimary outcomeIntervention armClinical trialsUnblinded observerClinical basisMulticomponent interventionAdditional fall
2020
D‐CARE: The Dementia Care Study: Design of a Pragmatic Trial of the Effectiveness and Cost Effectiveness of Health System–Based Versus Community‐Based Dementia Care Versus Usual Dementia Care
Reuben DB, Gill TM, Stevens A, Williamson J, Volpi E, Lichtenstein M, Jennings LA, Tan Z, Evertson L, Bass D, Weitzman L, Carnie M, Wilson N, Araujo K, Charpentier P, Meng C, Greene EJ, Dziura J, Liu J, Unger E, Yang M, Currie K, Lenoir KM, Green A, Abraham S, Vernon A, Samper‐Ternent R, Raji M, Hirst RM, Galloway R, Finney GR, Ladd I, Rahm AK, Borek P, Peduzzi P. D‐CARE: The Dementia Care Study: Design of a Pragmatic Trial of the Effectiveness and Cost Effectiveness of Health System–Based Versus Community‐Based Dementia Care Versus Usual Dementia Care. Journal Of The American Geriatrics Society 2020, 68: 2492-2499. PMID: 32949145, PMCID: PMC8086629, DOI: 10.1111/jgs.16862.Peer-Reviewed Original ResearchConceptsCommunity-based dementia careUsual careClinical trial sitesDementia careHealth systemCaregiver unmet needsNursing home placement ratesClinical health systemsDementia care specialistsUnit of randomizationQuality of lifeCost effectivenessDementia Care StudyPrimary outcomeClinical benefitSuperiority trialFunctional statusPragmatic trialCaregiver dyadsCare specialistsComprehensive careCaregiver distressCare studiesMedicare claimsNurse practitionersOptimizing Retention in a Pragmatic Trial of Community‐Living Older Persons: The STRIDE Study
Gill TM, McGloin JM, Shelton A, Bianco LM, Skokos EA, Latham NK, Ganz DA, Nyquist LV, Wallace RB, Carnie MB, Dykes PC, Goehring LA, Doyle M, Charpentier PA, Greene EJ, Araujo KL. Optimizing Retention in a Pragmatic Trial of Community‐Living Older Persons: The STRIDE Study. Journal Of The American Geriatrics Society 2020, 68: 1242-1249. PMID: 32212395, PMCID: PMC7707554, DOI: 10.1111/jgs.16356.Peer-Reviewed Original ResearchConceptsSerious fall injuriesPragmatic trialFall injuriesCommon reasonClinical sitesOlder personsCommunity-living personsLarge pragmatic trialPrimary care practicesCentral call centerRate of deathYears of ageVulnerable older personsRetention of participantsUS healthcare systemPragmatic clusterStudy withdrawalMultifactorial interventionElders StudySTRIDE studyHigh riskCare practicesParticipant retentionStudy outcomesInjury
2019
Association of Racial Disparities With Access to Kidney Transplant After the Implementation of the New Kidney Allocation System
Kulkarni S, Ladin K, Haakinson D, Greene E, Li L, Deng Y. Association of Racial Disparities With Access to Kidney Transplant After the Implementation of the New Kidney Allocation System. JAMA Surgery 2019, 154: 618-625. PMID: 30942882, PMCID: PMC6583835, DOI: 10.1001/jamasurg.2019.0512.Peer-Reviewed Original ResearchConceptsDeceased donor transplantsKidney allocation systemDonor transplantsKidney transplantTransplant probabilityDeath/Race/ethnicityHispanic individualsWhite individualsOrgan procurementBlack individualsNew kidney allocation systemRetrospective cohort studyWait-listed patientsKidney transplant databaseStatus changesAntibody categoriesLevel of sensitizationInactive statusInactive patientsTransplant databaseTransplant outcomesCohort studyMedian ageAntibody group
2017
Strategies to Reduce Injuries and Develop Confidence in Elders (STRIDE): A Cluster-Randomized Pragmatic Trial of a Multifactorial Fall Injury Prevention Strategy: Design and Methods
Bhasin S, Gill TM, Reuben DB, Latham NK, Gurwitz JH, Dykes P, McMahon S, Storer TW, Duncan PW, Ganz DA, Basaria S, Miller ME, Travison TG, Greene EJ, Dziura J, Esserman D, Allore H, Carnie MB, Fagan M, Hanson C, Baker D, Greenspan SL, Alexander N, Ko F, Siu AL, Volpi E, Wu AW, Rich J, Waring SC, Wallace R, Casteel C, Magaziner J, Charpentier P, Lu C, Araujo K, Rajeevan H, Margolis S, Eder R, McGloin JM, Skokos E, Wiggins J, Garber L, Clauser SB, Correa-De-Araujo R, Peduzzi P. Strategies to Reduce Injuries and Develop Confidence in Elders (STRIDE): A Cluster-Randomized Pragmatic Trial of a Multifactorial Fall Injury Prevention Strategy: Design and Methods. The Journals Of Gerontology Series A 2017, 73: 1053-1061. PMID: 29045582, PMCID: PMC6037050, DOI: 10.1093/gerona/glx190.Peer-Reviewed Original ResearchConceptsSerious fall injuriesInjury prevention strategiesFall injuriesPragmatic trialHealth care systemUsual carePrevention strategiesControl groupOlder adultsCare systemMultifactorial risk assessmentCommunity-living personsEnhanced usual carePrimary outcome rateIndividualized care plansPrimary care practicesTarget sample sizeEvidence-based informationSecondary outcomesPrimary outcomeOutcome ratesComanagement modelFall preventionSTRIDE studyMedical attention
2013
Age-related differences in agenda-driven monitoring of format and task information
Mitchell KJ, Ankudowich E, Durbin KA, Greene EJ, Johnson MK. Age-related differences in agenda-driven monitoring of format and task information. Neuropsychologia 2013, 51: 2427-2441. PMID: 23357375, PMCID: PMC3664244, DOI: 10.1016/j.neuropsychologia.2013.01.012.Peer-Reviewed Original ResearchConceptsOld-new recognitionMedial prefrontal cortexOlder adultsAge-related source memory deficitsPrefrontal cortexRepresentational areaSource memory deficitsVisual processing areasAge-related deficitsPattern of resultsLateral parietal cortexYoung adultsAge-related differencesFeatures of eventsSource memoryEquivalent deficitsReflective attentionParietal functionAge differencesTask informationMemory deficitsGreater trialParietal cortexReduced itemProcessing areas
2008
Refreshing One of Several Active Representations: Behavioral and Functional Magnetic Resonance Imaging Differences between Young and Older Adults
Raye CL, Mitchell KJ, Reeder JA, Greene EJ, Johnson MK. Refreshing One of Several Active Representations: Behavioral and Functional Magnetic Resonance Imaging Differences between Young and Older Adults. Journal Of Cognitive Neuroscience 2008, 20: 852-862. PMID: 18201130, DOI: 10.1162/jocn.2008.20508.Peer-Reviewed Original ResearchConceptsVentral frontal cortexActive representationOlder adultsFrontal cortexIrrelevant informationFunctional magnetic resonance imaging studyLeft dorsolateral frontal cortexYoung adultsDissociation of functionAge-related differencesDorsolateral frontal cortexMagnetic resonance imaging studyExecutive processesResonance imaging studyExecutive functionResponse timeNew wordsAnterior cingulateAge-related decreaseBehavioral studiesActive itemWordsCortexImaging differencesMedial area
2005
An fMRI investigation of short-term source memory in young and older adults
Mitchell KJ, Raye CL, Johnson MK, Greene EJ. An fMRI investigation of short-term source memory in young and older adults. NeuroImage 2005, 30: 627-633. PMID: 16256377, DOI: 10.1016/j.neuroimage.2005.09.039.Peer-Reviewed Original ResearchConceptsOld-new judgmentsSource memory deficitsFunctional magnetic resonance imagingOlder adultsPrefrontal cortexSource memory judgmentsPrevious fMRI findingsLateral prefrontal cortexDorsolateral prefrontal cortexSpecific source informationMemory judgmentsSource memoryRetention intervalFMRI investigationMemory procedureFMRI findingsMemory deficitsBrain areasYoung adultsJudgmentsMagnetic resonance imagingGreater activityAdultsSource informationCortex
2004
An Age-Related Deficit in Prefrontal Cortical Function Associated With Refreshing Information
Johnson MK, Mitchell KJ, Raye CL, Greene EJ. An Age-Related Deficit in Prefrontal Cortical Function Associated With Refreshing Information. Psychological Science 2004, 15: 127-132. PMID: 14738520, DOI: 10.1111/j.0963-7214.2004.01502009.x.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingLong-term memory benefitsYoung adultsOlder adultsBasic cognitive processesDorsolateral prefrontal cortexMemory benefitsCognitive processesCognitive tasksPrefrontal cortexFrontal componentReflective operationsPoor performanceAdultsDeficitsMagnetic resonance imagingFunction AssociatedResonance imagingTaskCortexItemsStrong evidenceInformation