2023
Estimating mortality in women with triple-negative breast cancer: The ‘ESTIMATE triple-negative’ tool
Leone J, Graham N, Leone J, Tolaney S, Leone B, Freedman R, Hassett M, Vallejo C, Winer E, Lin N, Tayob N. Estimating mortality in women with triple-negative breast cancer: The ‘ESTIMATE triple-negative’ tool. European Journal Of Cancer 2023, 189: 112930. PMID: 37356327, DOI: 10.1016/j.ejca.2023.05.018.Peer-Reviewed Original ResearchMeSH KeywordsBreastBreast NeoplasmsFemaleHumansNeoplasm StagingPrognosisSEER ProgramTriple Negative Breast NeoplasmsConceptsBreast cancer-specific mortalityTriple-negative breast cancerRisk of BCSMTumor characteristicsBreast cancerCumulative riskNon-metastatic triple-negative breast cancerMost tumor characteristicsCancer-specific mortalityRisk of deathPopulation-based riskHigh-grade triple-negative breast cancerCause mortalityMost patientsPathologic variablesInitial diagnosisHigh riskNew diagnosisPatientsMortalityDiagnosisYear 0RiskCancerWomen
2022
Estimating long-term mortality in women with hormone receptor-positive breast cancer: The ‘ESTIMATE’ tool
Leone JP, Graham N, Tolaney SM, Leone BA, Freedman RA, Hassett MJ, Leone J, Vallejo CT, Winer EP, Lin NU, Tayob N. Estimating long-term mortality in women with hormone receptor-positive breast cancer: The ‘ESTIMATE’ tool. European Journal Of Cancer 2022, 173: 20-29. PMID: 35841843, DOI: 10.1016/j.ejca.2022.06.029.Peer-Reviewed Original ResearchMeSH KeywordsAdultBreastBreast NeoplasmsFemaleHumansMiddle AgedNeoplasm StagingPrognosisSEER ProgramConceptsBreast cancer-specific mortalityHR-positive breast cancerBreast cancerCumulative riskCause mortalityTumor characteristicsRisk of BCSMHormone receptor-positive breast cancerReceptor-positive breast cancerCancer-specific mortalityEnd Results registryLong-term mortalityRisk of deathCancer patient subgroupsPopulation-based riskPathologic variablesInitial diagnosisPatient subgroupsSEER dataPatientsAge groupsCancerMortalityHormone receptorsDiagnosis
2021
Factors associated with late risks of breast cancer-specific mortality in the SEER registry
Leone JP, Vallejo CT, Hassett MJ, Leone J, Graham N, Tayob N, Freedman RA, Tolaney SM, Leone BA, Winer EP, Lin NU. Factors associated with late risks of breast cancer-specific mortality in the SEER registry. Breast Cancer Research And Treatment 2021, 189: 203-212. PMID: 33893907, PMCID: PMC8302525, DOI: 10.1007/s10549-021-06233-4.Peer-Reviewed Original ResearchMeSH KeywordsBreast NeoplasmsFemaleHumansKaplan-Meier EstimateNeoplasm StagingPrognosisRegistriesSEER ProgramConceptsBC-specific mortalityHR-positive breast cancerHR-negative breast cancerBreast cancerHR statusCumulative riskBreast cancer-specific mortalityCancer-specific mortalityT1a/bHormone receptor statusYear of diagnosisKaplan-Meier analysisLong-term riskBC deathConclusionThe risksGray regressionN2 diseaseLate relapseReceptor statusLate recurrenceSEER registryLater riskClinical trialsYear 5PatientsTwenty-year risks of breast cancer-specific mortality for stage III breast cancer in the surveillance, epidemiology, and end results registry
Leone JP, Leone BA, Tayob N, Hassett MJ, Leone J, Freedman RA, Tolaney SM, Winer EP, Vallejo CT, Lin NU. Twenty-year risks of breast cancer-specific mortality for stage III breast cancer in the surveillance, epidemiology, and end results registry. Breast Cancer Research And Treatment 2021, 187: 843-852. PMID: 33590387, DOI: 10.1007/s10549-021-06121-x.Peer-Reviewed Original ResearchConceptsRisk of BCSMBreast cancer-specific mortalityStage III breast cancerHR-negative diseaseHR-positive diseaseCancer-specific mortalityBreast cancerLate deathsNodal statusTumor sizeUnknown hormone receptor statusHR-positive tumorsEnd Results registryHormone receptor statusEnd Results (SEER) dataTraditional clinicopathologic factorsCumulative incidence functionGray regressionMethodsUsing SurveillanceAxillary nodesClinicopathologic factorsReceptor statusStage subgroupsPrimary tumorTumor grade
2018
Breast cancer‐specific survival by age: Worse outcomes for the oldest patients
Freedman RA, Keating NL, Lin NU, Winer EP, Vaz‐Luis I, Lii J, Exman P, Barry WT. Breast cancer‐specific survival by age: Worse outcomes for the oldest patients. Cancer 2018, 124: 2184-2191. PMID: 29499074, PMCID: PMC5935594, DOI: 10.1002/cncr.31308.Peer-Reviewed Original ResearchConceptsBreast cancer-specific deathCancer-specific deathTriple-negative diseaseHuman epidermal growth factor receptor 2Epidermal growth factor receptor 2Growth factor receptor 2Breast cancer outcomesOlder patientsFactor receptor 2Breast cancerCancer outcomesReceptor 2Disease subtypesWorse breast cancer outcomesHR-positive diseaseCancer stage IEnd Results (SEER) dataAmerican Joint CommitteePopulation-based cohortStage of diseaseGray regression modelsAdjusted hazardClinical variablesDisease stageHigh risk
2016
Time trends in incidence rates and survival of newly diagnosed stage IV breast cancer by tumor histology: a population-based analysis
Di Meglio A, Freedman RA, Lin NU, Barry WT, Metzger-Filho O, Keating NL, King TA, Sertoli MR, Boccardo F, Winer EP, Vaz-Luis I. Time trends in incidence rates and survival of newly diagnosed stage IV breast cancer by tumor histology: a population-based analysis. Breast Cancer Research And Treatment 2016, 157: 587-596. PMID: 27271765, DOI: 10.1007/s10549-016-3845-5.Peer-Reviewed Original ResearchConceptsMetastatic breast cancerMedian overall survivalOverall survivalPopulation-based analysisDuctal carcinomaLobular carcinomaAnnual percent changeBreast cancerIncidence rateDe novo metastatic breast cancerEnd Results 9 registriesHormone receptor-positive tumorsNovo metastatic breast cancerMultivariable Cox regression modelsStage IV breast cancerAnnual age-adjusted incidence ratesAge-adjusted incidence ratesAdjusted hazard ratioBetter overall survivalDate of diagnosisReceptor-positive tumorsBreast cancer incidenceCox regression modelHazard ratioTumor histologyTrends in the use of mastectomy in women with small node-negative breast cancer treated at US academic centers
Vaz-Luis I, Hughes ME, Cronin A, Rugo HS, Edge SB, Moy B, Theriault RL, Hassett MJ, Winer EP, Lin NU. Trends in the use of mastectomy in women with small node-negative breast cancer treated at US academic centers. Breast Cancer Research And Treatment 2016, 155: 569-578. PMID: 26868124, DOI: 10.1007/s10549-016-3707-1.Peer-Reviewed Original ResearchConceptsBreast-conserving surgeryUse of mastectomyBreast cancer patientsInitial mastectomyBilateral mastectomyBreast cancerDefinitive surgeryInitial surgeryCancer patientsNational Comprehensive Cancer Network centersSmall node-negative breast cancersStage I breast cancer patientsNode-negative breast cancerStage I breast cancerRisk breast cancerSubstantial institutional variationProportion of patientsProspective cohort studyUS academic centersI breast cancerType of surgeryLonger median timeChoice of surgeryEquivalent survival outcomesSignificant institutional variation
2015
Racial differences in outcomes for patients with metastatic breast cancer by disease subtype
Vaz-Luis I, Lin NU, Keating NL, Barry WT, Lii H, Winer EP, Freedman RA. Racial differences in outcomes for patients with metastatic breast cancer by disease subtype. Breast Cancer Research And Treatment 2015, 151: 697-707. PMID: 26022349, DOI: 10.1007/s10549-015-3432-1.Peer-Reviewed Original ResearchConceptsMetastatic breast cancerDe novo metastatic breast cancerNovo metastatic breast cancerBreast cancer-specific survivalCancer-specific survivalHER2-positive tumorsOverall survivalBreast cancerTreatment patternsBlack patientsRacial differencesDisease subgroupsMultivariate Cox proportional modelEnd Results-Medicare dataHuman epidermal growth factor receptor 2Epidermal growth factor receptor 2Impact of raceHER2-positive diseaseHR-negative diseaseHR-negative tumorsLonger median OSMedian overall survivalGrowth factor receptor 2Survival of womenCox proportional models
2014
Patterns of chemotherapy, toxicity, and short-term outcomes for older women receiving adjuvant trastuzumab-based therapy
Freedman RA, Vaz-Luis I, Barry WT, Lii H, Lin NU, Winer EP, Keating NL. Patterns of chemotherapy, toxicity, and short-term outcomes for older women receiving adjuvant trastuzumab-based therapy. Breast Cancer Research And Treatment 2014, 145: 491-501. PMID: 24756187, DOI: 10.1007/s10549-014-2968-9.Peer-Reviewed Original ResearchConceptsNon-standard chemotherapyTrastuzumab-based therapyAdjuvant trastuzumab-based therapyOlder womenChemotherapy receiptHazard ratioBreast cancerHER2-positive breast cancerPattern of chemotherapyPropensity-weighted cohortsToxicity-related hospitalizationAdjusted hazard ratioTreatment-related toxicityMonths of chemotherapyShort-term outcomesMultivariable logistic regressionPopulation-based cohortPropensity score adjustmentAssociation of ageShort-term survivalComorbidity scoreOlder patientsTreatment toxicityWorse survivalHospital eventsDuration and Toxicity of Adjuvant Trastuzumab in Older Patients With Early-Stage Breast Cancer: A Population-Based Study
Vaz-Luis I, Keating NL, Lin NU, Lii H, Winer EP, Freedman RA. Duration and Toxicity of Adjuvant Trastuzumab in Older Patients With Early-Stage Breast Cancer: A Population-Based Study. Journal Of Clinical Oncology 2014, 32: 927-934. PMID: 24516021, PMCID: PMC3948095, DOI: 10.1200/jco.2013.51.1261.Peer-Reviewed Original ResearchConceptsEarly-stage breast cancerCardiac eventsOlder patientsBreast cancerTrastuzumab completionAdjuvant trastuzumabTreatment completionOlder womenHuman epidermal growth factor receptorAdjuvant trastuzumab useAge 76 yearsDays of therapyMost older patientsSignificant cardiac eventsMultivariable logistic regressionEpidermal growth factor receptorGrowth factor receptorMore comorbiditiesTrastuzumab useComorbidity scorePatient ageHospital admissionOptimal treatmentLower oddsMedicare data
2013
Racial/Ethnic Differences in Receipt of Timely Adjuvant Therapy for Older Women with Breast Cancer: Are Delays Influenced by the Hospitals Where Patients Obtain Surgical Care?
Freedman RA, He Y, Winer EP, Keating NL. Racial/Ethnic Differences in Receipt of Timely Adjuvant Therapy for Older Women with Breast Cancer: Are Delays Influenced by the Hospitals Where Patients Obtain Surgical Care? Health Services Research 2013, 48: 1669-1683. PMID: 23663229, PMCID: PMC3796107, DOI: 10.1111/1475-6773.12063.Peer-Reviewed Original ResearchConceptsTreatment delayBreast cancerTimely adjuvant therapyEnd Results (SEER) dataMultivariable logistic regressionEthnic differencesRace/ethnicityAdjuvant chemotherapyAdjuvant therapyMedicare claimsSurgical careHigher oddsOlder womenHispanic womenStage IHospitalLogistic regressionRacial disparitiesWomenPatientsBlack womenCancerCareResult dataImportant contributor
2010
Outcomes following local therapy for early-stage breast cancer in non-trial populations
Keating NL, Landrum MB, Brooks JM, Chrischilles EA, Winer EP, Wright K, Volya R. Outcomes following local therapy for early-stage breast cancer in non-trial populations. Breast Cancer Research And Treatment 2010, 125: 803-813. PMID: 20376555, PMCID: PMC2924956, DOI: 10.1007/s10549-010-0865-4.Peer-Reviewed Original ResearchConceptsBreast-conserving surgeryEarly-stage breast cancerClinical trialsBreast cancerEarly-stage breast cancer patientsPrimary breast cancer therapyPrimary breast cancer treatmentEnd Results cancer registryNon-trial populationBreast cancer patientsPopulation-based dataBreast cancer treatmentBreast cancer therapyNon-selected populationPropensity score analysisMedicare administrative dataMore mastectomiesPrimary therapyLocal therapySurveillance EpidemiologyAdjusted survivalCancer RegistryCancer patientsHospital characteristicsMastectomy
2009
Racial Differences in Definitive Breast Cancer Therapy in Older Women
Keating NL, Kouri E, He Y, Weeks JC, Winer EP. Racial Differences in Definitive Breast Cancer Therapy in Older Women. Medical Care 2009, 47: 765-773. PMID: 19536008, DOI: 10.1097/mlr.0b013e31819e1fe7.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedBlack or African AmericanBreast NeoplasmsChi-Square DistributionFemaleHealth Services ResearchHealthcare DisparitiesHospitalsHumansLogistic ModelsMastectomyMedicareMultivariate AnalysisPractice Patterns, Physicians'Quality of Health CareSEER ProgramSensitivity and SpecificitySocioeconomic FactorsUnited StatesWhite PeopleConceptsHigh-volume hospitalsDefinitive primary therapyHigh-quality hospitalsBreast-conserving surgeryBreast cancer therapyBreast cancerPrimary therapyWhite womenRacial disparitiesStage I/II breast cancerBlack womenPrimary breast cancer therapyEarly-stage breast cancerLow-volume hospitalsBreast cancer patientsBreast cancer surgeryPatterns of careSEER-Medicare databaseCancer therapyPopulation-based sampleOlder Black womenDefinitive therapyVolume hospitalsCancer surgeryCancer patients
2008
Ten-Year Survival and Cost Following Breast Cancer Recurrence: Estimates from SEER-Medicare Data
Stokes ME, Thompson D, Montoya EL, Weinstein MC, Winer EP, Earle CC. Ten-Year Survival and Cost Following Breast Cancer Recurrence: Estimates from SEER-Medicare Data. Value In Health 2008, 11: 213-220. PMID: 18380633, DOI: 10.1111/j.1524-4733.2007.00226.x.Peer-Reviewed Original ResearchConceptsBreast cancer recurrenceBreast cancer eventsContralateral breast cancerNonmetastatic breast cancerSEER-Medicare dataBreast cancerCancer recurrenceDistant recurrenceSurveillance EpidemiologyCancer eventsMedicare claimsNational Cancer Institute's Surveillance EpidemiologyBreast cancer leadEnd Results registryTen-year survivalImpact of recurrencePaucity of dataMedian survivalPharmacologic therapyLocal recurrenceRetrospective analysisRecurrencePatientsCancer leadCancer
2007
Care in the Months before Death and Hospice Enrollment Among Older Women with Advanced Breast Cancer
Keating NL, Landrum MB, Guadagnoli E, Winer EP, Ayanian JZ. Care in the Months before Death and Hospice Enrollment Among Older Women with Advanced Breast Cancer. Journal Of General Internal Medicine 2007, 23: 11-18. PMID: 17939006, PMCID: PMC2173914, DOI: 10.1007/s11606-007-0422-y.Peer-Reviewed Original ResearchConceptsTypes of physiciansAdvanced breast cancerWeeks of deathHospice useOutpatient visitsCancer specialistsBreast cancerOlder womenStage III/IV breast cancerEnd Results-Medicare databaseAdvanced breast cancer patientsBreast cancer patientsPrimary care providersPopulation-based sampleTiming of enrollmentHospice referralPatient characteristicsHospice enrollmentHospitalized patientsCancer careCancer patientsAdjusted ratesCare providersHospitalizationPatientsCost-Effectiveness of Switching to Exemestane after 2 to 3 Years of Therapy with Tamoxifen in Postmenopausal Women with Early-Stage Breast Cancer
Thompson D, Taylor DC, Montoya EL, Winer EP, Jones SE, Weinstein MC. Cost-Effectiveness of Switching to Exemestane after 2 to 3 Years of Therapy with Tamoxifen in Postmenopausal Women with Early-Stage Breast Cancer. Value In Health 2007, 10: 367-376. PMID: 17888101, DOI: 10.1111/j.1524-4733.2007.00190.x.Peer-Reviewed Original ResearchMeSH KeywordsAgedAndrostadienesAntineoplastic ProtocolsAromatase InhibitorsBreast NeoplasmsCost-Benefit AnalysisDrug Administration ScheduleFemaleForecastingHumansMarkov ChainsMiddle AgedNeoplasm Recurrence, LocalPostmenopauseQuality-Adjusted Life YearsSEER ProgramSelective Estrogen Receptor ModulatorsTamoxifenConceptsIntergroup Exemestane StudyDisease-free survivalDisease-related eventsTreatment strategiesEarly-stage breast cancer patientsEarly-stage breast cancerProlongs disease-free survivalCost-effective treatment strategyIncremental cost-effectiveness ratioYears of tamoxifenYears of therapyBreast cancer patientsSEER-Medicare dataBreast cancer statusLifetime medical care costsMedical care costsCost-effectiveness ratioTamoxifen therapyPostmenopausal womenRecurrence rateCancer careCancer patientsPatient transitionsAromatase inhibitorsBreast cancerSurveillance Testing Among Survivors of Early-Stage Breast Cancer
Keating NL, Landrum MB, Guadagnoli E, Winer EP, Ayanian JZ. Surveillance Testing Among Survivors of Early-Stage Breast Cancer. Journal Of Clinical Oncology 2007, 25: 1074-1081. PMID: 17369571, DOI: 10.1200/jco.2006.08.6876.Peer-Reviewed Original ResearchMeSH KeywordsAgedBreast NeoplasmsCohort StudiesDiagnostic Tests, RoutineFemaleFollow-Up StudiesGuideline AdherenceHumansLogistic ModelsLong-Term CareMedical OncologyNeoplasm StagingOdds RatioOffice VisitsPopulation SurveillancePractice Guidelines as TopicPractice Patterns, Physicians'Primary Health CareSEER ProgramSurvivorsTime FactorsUnited StatesUnnecessary ProceduresConceptsBreast cancer survivorsChest X-rayMedical oncologistsCancer survivorsBreast cancerAbdominal imagingAntigen testingBone scanStage I/II breast cancerEarly-stage breast cancer patientsMost breast cancer survivorsEnd Results-Medicare dataSurveillance testingEarly-stage breast cancerRepeated-measures logistic regressionBreast cancer patientsLow-risk populationPopulation-based cohortTypes of physiciansRoutine surveillance testingRate of testingAntigen testCancer patientsWomen's ageSurveillance years
2006
Factors Related to Underuse of Surveillance Mammography Among Breast Cancer Survivors
Keating NL, Landrum MB, Guadagnoli E, Winer EP, Ayanian JZ. Factors Related to Underuse of Surveillance Mammography Among Breast Cancer Survivors. Journal Of Clinical Oncology 2006, 24: 85-94. PMID: 16382117, DOI: 10.1200/jco.2005.02.4174.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBreast NeoplasmsCohort StudiesFemaleHumansMammographySEER ProgramSurvivorsConceptsBreast cancer survivorsSurveillance mammographyCancer survivorsMonth 7Elderly breast cancer survivorsEnd Results-Medicare dataOlder breast cancer survivorsAnnual surveillance mammographyPrimary surgical therapyRepeated-measures logistic regressionLower mammography ratesQuarter of womenPopulation-based sampleService Medicare enrolleesBreast cancer diagnosisSurgical therapyAnnual mammographyGuideline recommendationsMedical oncologistsMultivariable analysisNonclinical factorsMammography ratesBreast cancerMammography useStage I
2005
The association of ambulatory care with breast cancer stage at diagnosis among medicare beneficiaries
Keating NL, Landrum MB, Ayanian JZ, Winer EP, Guadagnoli E. The association of ambulatory care with breast cancer stage at diagnosis among medicare beneficiaries. Journal Of General Internal Medicine 2005, 20: 38-44. PMID: 15693926, PMCID: PMC1490029, DOI: 10.1111/j.1525-1497.2004.40079.x.Peer-Reviewed Original ResearchConceptsPrimary care physiciansCare physiciansBreast cancer diagnosisAdvanced cancerOutpatient careNumber of visitsMedical specialistsAdvanced stage diagnosisPreventive care visitsRetrospective cohort studyCancer diagnosisBreast cancer stagePercent of womenPopulation-based sampleCare visitsCohort studyCancer RegistryCancer stageUse of servicesElderly womenAdjusted ratesBreast cancerLower median incomeAmbulatory careHigh risk
2003
Consultation with a medical oncologist before surgery and type of surgery among elderly women with early-stage breast cancer.
Keating NL, Landrum MB, Ayanian JZ, Winer EP, Guadagnoli E. Consultation with a medical oncologist before surgery and type of surgery among elderly women with early-stage breast cancer. Journal Of Clinical Oncology 2003, 21: 4532-9. PMID: 14673040, DOI: 10.1200/jco.2003.05.131.Peer-Reviewed Original ResearchConceptsBreast-conserving surgeryDefinitive surgeryMedical oncologistsType of surgeryElderly womenAxillary dissectionBreast cancerEarly-stage breast cancerGuideline-recommended careRetrospective cohort studyAxillary node dissectionBreast cancer treatmentPercent of womenPopulation-based sampleComorbid illnessesNode dissectionCohort studyGuideline recommendationsDifferentiated cancerTeaching hospitalAdjusted proportionSurgeryOncologistsCancer treatmentWomen