2021
Optimal medical therapy with or without surgical revascularization and long-term outcomes in ischemic cardiomyopathy
Farsky PS, White J, Al-Khalidi HR, Sueta CA, Rouleau J, Panza J, Velazquez E, O'Connor C, Investigators W, Dabrowski R, Djokovic L, Drazner M, Haddad H, Ali I, Keltai M, Naik A, Sopko G, Golba K, Andersson B, Carson P, Kukulski T. Optimal medical therapy with or without surgical revascularization and long-term outcomes in ischemic cardiomyopathy. Journal Of Thoracic And Cardiovascular Surgery 2021, 164: 1890-1899.e4. PMID: 33610365, PMCID: PMC8260609, DOI: 10.1016/j.jtcvs.2020.12.094.Peer-Reviewed Original ResearchConceptsOptimal medical therapyCoronary artery bypassMedical therapyArtery bypassIschemic cardiomyopathyCause mortalityIschemic Heart Failure (STICH) trialVentricular ejection fraction 35Improved long-term survivalEjection fraction 35Angiotensin receptor blockersHeart Failure TrialLower cardiovascular mortalityMultivariable Cox modelOutcomes of patientsVentricular ejection fractionCoronary artery diseaseLong-term outcomesLong-term survivalSurgical revascularizationReceptor blockersCardiovascular mortalityAntiplatelet drugsArtery diseaseEjection fraction
2019
CABG Improves Outcomes in Patients With Ischemic Cardiomyopathy 10-Year Follow-Up of the STICH Trial
Howlett JG, Stebbins A, Petrie MC, Jhund PS, Castelvecchio S, Cherniavsky A, Sueta CA, Roy A, Piña IL, Wurm R, Drazner MH, Andersson B, Batlle C, Senni M, Chrzanowski L, Merkely B, Carson P, Desvigne-Nickens PM, Lee KL, Velazquez EJ, Al-Khalidi HR, Investigators S. CABG Improves Outcomes in Patients With Ischemic Cardiomyopathy 10-Year Follow-Up of the STICH Trial. JACC Heart Failure 2019, 7: 878-887. PMID: 31521682, PMCID: PMC7375257, DOI: 10.1016/j.jchf.2019.04.018.Peer-Reviewed Original ResearchConceptsRecurrent event analysisSTICH trialCause hospitalizationCause-specific hospitalizationsNon-CV eventsTotal cardiovascular hospitalizationsCoronary artery bypassVentricular ejection fractionCABG groupCause deathHF hospitalizationArtery bypassCardiovascular causesCardiovascular hospitalizationEjection fractionHeart failureIschemic cardiomyopathyRecurrent hospitalizationsMost hospitalizationsEvent analysisHospitalizationPatientsCABGRecurrent eventsTotalMyocardial Viability and Long-Term Outcomes in Ischemic Cardiomyopathy
Panza JA, Ellis AM, Al-Khalidi HR, Holly TA, Berman DS, Oh JK, Pohost GM, Sopko G, Chrzanowski L, Mark DB, Kukulski T, Favaloro LE, Maurer G, Farsky PS, Tan RS, Asch FM, Velazquez EJ, Rouleau JL, Lee KL, Bonow RO. Myocardial Viability and Long-Term Outcomes in Ischemic Cardiomyopathy. New England Journal Of Medicine 2019, 381: 739-748. PMID: 31433921, PMCID: PMC6814246, DOI: 10.1056/nejmoa1807365.Peer-Reviewed Original ResearchMeSH KeywordsAgedCoronary Artery BypassEchocardiography, StressFemaleFollow-Up StudiesHeartHumansIncidenceKaplan-Meier EstimateMaleMiddle AgedMyocardial IschemiaProportional Hazards ModelsProspective StudiesStroke VolumeTomography, Emission-Computed, Single-PhotonTreatment OutcomeVentricular Function, LeftConceptsLeft ventricular ejection fractionVentricular ejection fractionMedical therapyEjection fractionMyocardial viabilityIschemic cardiomyopathyLeft ventricular systolic functionGoals of revascularizationCoronary artery bypassPrimary end pointVentricular systolic functionCoronary artery diseaseLeft ventricular functionLong-term outcomesLong-term survivalSurgical revascularizationDobutamine echocardiographyMedian durationSystolic functionArtery diseaseVentricular functionViable myocardiumLong-term benefitsLower incidenceCABGBurden of medical co‐morbidities and benefit from surgical revascularization in patients with ischaemic cardiomyopathy
Ambrosy AP, Stevens SR, Al‐Khalidi H, Rouleau JL, Bouabdallaoui N, Carson PE, Adlbrecht C, Cleland JGF, Dabrowski R, Golba KS, Pina IL, Sueta CA, Roy A, Sopko G, Bonow RO, Velazquez EJ, Investigators O. Burden of medical co‐morbidities and benefit from surgical revascularization in patients with ischaemic cardiomyopathy. European Journal Of Heart Failure 2019, 21: 373-381. PMID: 30698316, PMCID: PMC6818499, DOI: 10.1002/ejhf.1404.Peer-Reviewed Original ResearchConceptsCharlson co-morbidity indexCCI scoreSurgical revascularizationEjection fractionMedical therapySTICH trialHeart failureIschemic cardiomyopathyKansas City Cardiomyopathy QuestionnaireCo-morbidity indexCoronary artery bypassCo-morbid conditionsHealth-related qualityCoronary artery diseaseRisk of deathProportional hazards modelYears of ageTreatment effectsGreater functional limitationsArtery bypassCause mortalityIschemic etiologyArtery diseaseWalk testBaseline confounders
2018
The association between blood pressure and long-term outcomes of patients with ischaemic cardiomyopathy with and without surgical revascularization: an analysis of the STICH trial
Andersson B, She L, Tan RS, Jeemon P, Mokrzycki K, Siepe M, Romanov A, Favaloro LE, Djokovic LT, Raju PK, Betlejewski P, Racine N, Ostrzycki A, Nawarawong W, Das S, Rouleau JL, Sopko G, Lee KL, Velazquez EJ, Panza JA. The association between blood pressure and long-term outcomes of patients with ischaemic cardiomyopathy with and without surgical revascularization: an analysis of the STICH trial. European Heart Journal 2018, 39: 3464-3471. PMID: 30113633, PMCID: PMC6166135, DOI: 10.1093/eurheartj/ehy438.Peer-Reviewed Original ResearchConceptsBlood pressureCoronary artery diseaseHigh blood pressureMortality outcomesSTICH trialArtery diseaseHeart failureIschemic cardiomyopathyLandmark analysisInfluence of BPLong-term mortality outcomesBP-lowering medicationsIschemic HF patientsCoronary artery bypassOutcomes of patientsBaseline blood pressureDiastolic blood pressureLower blood pressureLong-term outcomesSystolic BP valuesCABG treatmentSurgical revascularizationArtery bypassHF patientsVentricular dysfunctionSix-minute walk distance after coronary artery bypass grafting compared with medical therapy in ischaemic cardiomyopathy
Stewart RAH, Szalewska D, Stebbins A, Al-Khalidi HR, Cleland JGH, Rynkiewicz A, Drazner MH, White HD, Mark DB, Roy A, Kosevic D, Rajda M, Jasinski M, Leng CY, Tungsubutra W, Desvigne-Nickens P, Velazquez EJ, Petrie MC. Six-minute walk distance after coronary artery bypass grafting compared with medical therapy in ischaemic cardiomyopathy. Open Heart 2018, 5: e000752. PMID: 29531766, PMCID: PMC5845417, DOI: 10.1136/openhrt-2017-000752.Peer-Reviewed Original ResearchCoronary artery bypass surgeryIschemic left ventricular dysfunctionLeft ventricular dysfunctionWalk distanceVentricular dysfunctionMedical therapyMED groupFunctional capacityNew York Heart Association classSix-minute walk distanceMin walk distanceCoronary artery bypassArtery bypass surgeryVentricular ejection fractionCoronary artery diseaseArtery bypassBypass surgeryArtery diseaseAssociation classEjection fractionIschemic cardiomyopathySurgical treatmentTreatment allocationDisease trialsPatients
2017
Value of Cardiovascular Magnetic Resonance Imaging–Derived Baseline Left Ventricular Ejection Fraction and Volumes for Precise Risk Stratification of Patients With Ischemic Cardiomyopathy: Insights From the Surgical Treatment for Ischemic Heart Failure (STICH) Trial
Pai RG, Varadarajan P, Rouleau JL, Stebbins AL, Velazquez EJ, Al-Khalidi HR, Pohost GM. Value of Cardiovascular Magnetic Resonance Imaging–Derived Baseline Left Ventricular Ejection Fraction and Volumes for Precise Risk Stratification of Patients With Ischemic Cardiomyopathy: Insights From the Surgical Treatment for Ischemic Heart Failure (STICH) Trial. JAMA Cardiology 2017, 2: 577-579. PMID: 28199489, PMCID: PMC5814980, DOI: 10.1001/jamacardio.2016.5492.Peer-Reviewed Original ResearchMeSH KeywordsAgedCardiac Surgical ProceduresCardiomyopathiesFemaleHeart FailureHeart VentriclesHumansKaplan-Meier EstimateMagnetic Resonance ImagingMagnetic Resonance Imaging, CineMaleMiddle AgedMortalityMultivariate AnalysisMyocardial IschemiaOrgan SizePlastic Surgery ProceduresRisk AssessmentStroke VolumeConceptsIschemic Heart Failure (STICH) trialCardiovascular magnetic resonance imagingHeart Failure TrialVentricular ejection fractionPrecise risk stratificationMagnetic resonance imagingEjection fractionIschemic cardiomyopathySurgical treatmentFailure TrialRisk stratificationResonance imagingPatientsCardiomyopathyBaselineTrials
2016
Coronary-Artery Bypass Surgery in Patients with Ischemic Cardiomyopathy
Velazquez EJ, Lee KL, Jones RH, Al-Khalidi HR, Hill JA, Panza JA, Michler RE, Bonow RO, Doenst T, Petrie MC, Oh JK, She L, Moore VL, Desvigne-Nickens P, Sopko G, Rouleau JL. Coronary-Artery Bypass Surgery in Patients with Ischemic Cardiomyopathy. New England Journal Of Medicine 2016, 374: 1511-1520. PMID: 27040723, PMCID: PMC4938005, DOI: 10.1056/nejmoa1602001.Peer-Reviewed Original ResearchConceptsMedical therapy groupCardiovascular causesCoronary artery diseaseMedical therapyCABG groupArtery diseaseIschemic cardiomyopathySevere left ventricular systolic dysfunctionGuideline-directed medical therapyLeft ventricular systolic dysfunctionMajor secondary outcomesCoronary artery bypassPrimary outcome eventVentricular systolic dysfunctionArtery bypass surgeryCohort of patientsRate of deathSystolic dysfunctionBypass surgeryMedian durationSecondary outcomesSurvival benefitEjection fractionHeart failurePrimary outcomeGetting to a Man's Heart through His Colon
Samsky MD, DeVore AD, Durkin M, Stout JE, Velazquez EJ, Milano CA. Getting to a Man's Heart through His Colon. Texas Heart Institute Journal 2016, 43: 168-70. PMID: 27127437, PMCID: PMC4845564, DOI: 10.14503/thij-14-4946.Peer-Reviewed Original ResearchConceptsLeft ventricular pseudoaneurysmVentricular pseudoaneurysmDor procedureVentricular apexIschemic Heart Failure (STICH) trialHeart Failure TrialCoronary artery bypassAnterior chest wallLeft ventricular apexLeft ventricular cavityDifficile bacteremiaSTICH trialArtery bypassPulsatile massTransthoracic echocardiogramDacron patchIschemic cardiomyopathySurgical explorationSurgical treatmentFailure TrialHemorrhagic shockPurulent materialThoracotomy siteChest wallPericardial space
2015
Severity of Remodeling, Myocardial Viability, and Survival in Ischemic LV Dysfunction After Surgical Revascularization
Bonow RO, Castelvecchio S, Panza JA, Berman DS, Velazquez EJ, Michler RE, She L, Holly TA, Desvigne-Nickens P, Kosevic D, Rajda M, Chrzanowski L, Deja M, Lee KL, White H, Oh JK, Doenst T, Hill JA, Rouleau JL, Menicanti L, Investigators S. Severity of Remodeling, Myocardial Viability, and Survival in Ischemic LV Dysfunction After Surgical Revascularization. JACC Cardiovascular Imaging 2015, 8: 1121-1129. PMID: 26363840, PMCID: PMC4633018, DOI: 10.1016/j.jcmg.2015.03.013.Peer-Reviewed Original ResearchMeSH KeywordsAgedCoronary Artery BypassCoronary Artery DiseaseEchocardiography, StressFemaleHumansKaplan-Meier EstimateMaleMiddle AgedMyocardiumPredictive Value of TestsProportional Hazards ModelsProspective StudiesRecovery of FunctionRisk FactorsStroke VolumeTime FactorsTissue SurvivalTomography, Emission-Computed, Single-PhotonTreatment OutcomeUnited StatesVentricular Dysfunction, LeftVentricular Function, LeftVentricular RemodelingConceptsEnd-systolic volume indexEnd-systolic volumeEffect of CABGIschemic LV dysfunctionMedical therapyMyocardial viabilityLV dysfunctionViable myocardiumLV end-systolic volume indexMedian end-systolic volume indexSmaller end-systolic volumeCoronary artery bypassLV systolic dysfunctionMarker of severityCoronary artery diseaseLeft ventricular remodelingPre-specified criteriaSingle photon emissionSTICH trialSurgical revascularizationArtery bypassDobutamine echocardiographySystolic dysfunctionArtery diseaseIschemic cardiomyopathyComparison of Transesophageal and Transthoracic Echocardiographic Measurements of Mechanism and Severity of Mitral Regurgitation in Ischemic Cardiomyopathy (from the Surgical Treatment of Ischemic Heart Failure Trial)
Grayburn PA, She L, Roberts BJ, Golba KS, Mokrzycki K, Drozdz J, Cherniavsky A, Przybylski R, Wrobel K, Asch FM, Holly TA, Haddad H, Yii M, Maurer G, Kron I, Schaff H, Velazquez EJ, Oh JK. Comparison of Transesophageal and Transthoracic Echocardiographic Measurements of Mechanism and Severity of Mitral Regurgitation in Ischemic Cardiomyopathy (from the Surgical Treatment of Ischemic Heart Failure Trial). The American Journal Of Cardiology 2015, 116: 913-918. PMID: 26170249, PMCID: PMC4554976, DOI: 10.1016/j.amjcard.2015.06.015.Peer-Reviewed Original ResearchConceptsTransesophageal echocardiographyMitral regurgitationIschemic cardiomyopathyMR gradeIschemic Heart Failure (STICH) trialMechanism of MRBaseline transesophageal echocardiographyHeart Failure TrialIndependent core laboratoryIschemic heart diseaseFunctional mitral regurgitationComparison of TransesophagealMitral annular diameterModest correlationMitral annulus diameterTransthoracic echocardiographic measurementsTransthoracic echocardiography imagingTenting areaBlood pressureSurgical treatmentFailure TrialEchocardiographic measurementsHeart diseaseTTE measurementsAnnulus diameterImpact of surgical ventricular reconstruction on sphericity index in patients with ischaemic cardiomyopathy: follow‐up from the STICH trial
Choi J, Daly RC, Lin G, Lahr BD, Wiste HJ, Beaver TM, Iacovoni A, Malinowski M, Friedrich I, Rouleau JL, Favaloro RR, Sopko G, Lang IM, White HD, Milano CA, Jones RH, Lee KL, Velazquez EJ, Oh JK. Impact of surgical ventricular reconstruction on sphericity index in patients with ischaemic cardiomyopathy: follow‐up from the STICH trial. European Journal Of Heart Failure 2015, 17: 453-463. PMID: 25779355, PMCID: PMC4664050, DOI: 10.1002/ejhf.256.Peer-Reviewed Original ResearchConceptsSurgical ventricular reconstructionSVR groupSphericity indexVentricular reconstructionTreatment strategiesCoronary artery bypass graft surgeryIschemic Heart Failure (STICH) trialArtery bypass graft surgeryLV end-systolic volumeBypass graft surgeryHeart Failure TrialLV filling pressureEnd-systolic volumeIschemic cardiomyopathy patientsSmaller LV volumesLower sphericity indexImproved LVEFSTICH trialGraft surgeryWorse survivalIschemic cardiomyopathySurgical treatmentClinical outcomesFailure TrialMitral regurgitation
2014
Extent of Coronary and Myocardial Disease and Benefit From Surgical Revascularization in LV Dysfunction
Panza JA, Velazquez EJ, She L, Smith PK, Nicolau JC, Favaloro RR, Gradinac S, Chrzanowski L, Prabhakaran D, Howlett JG, Jasinski M, Hill JA, Szwed H, Larbalestier R, Desvigne-Nickens P, Jones RH, Lee KL, Rouleau JL. Extent of Coronary and Myocardial Disease and Benefit From Surgical Revascularization in LV Dysfunction. Journal Of The American College Of Cardiology 2014, 64: 553-561. PMID: 25104523, PMCID: PMC4129547, DOI: 10.1016/j.jacc.2014.04.064.Peer-Reviewed Original ResearchConceptsCoronary artery bypass graft surgeryOptimal medical therapyCoronary artery diseaseEnd-systolic volume indexEjection fractionSurgical revascularizationIschemic cardiomyopathyMedical therapyPrognostic factorsExtensive coronary artery diseaseArtery bypass graft surgeryIschemic left ventricular dysfunctionAdvanced ischemic cardiomyopathySubsequent survival benefitBypass graft surgeryHigh operative riskLeft ventricular dysfunctionGraft surgeryLV dysfunctionRevascularization TrialVentricular dysfunctionOperative riskSurvival benefitArtery diseaseMyocardial dysfunction
2013
Mechanisms of Functional Mitral Regurgitation in Ischemic Cardiomyopathy Determined by Transesophageal Echocardiography (from the Surgical Treatment for Ischemic Heart Failure Trial)
Golba K, Mokrzycki K, Drozdz J, Cherniavsky A, Wrobel K, Roberts BJ, Haddad H, Maurer G, Yii M, Asch FM, Handschumacher MD, Holly TA, Przybylski R, Kron I, Schaff H, Aston S, Horton J, Lee KL, Velazquez EJ, Grayburn PA, Investigators S. Mechanisms of Functional Mitral Regurgitation in Ischemic Cardiomyopathy Determined by Transesophageal Echocardiography (from the Surgical Treatment for Ischemic Heart Failure Trial). The American Journal Of Cardiology 2013, 112: 1812-1818. PMID: 24035166, PMCID: PMC3830629, DOI: 10.1016/j.amjcard.2013.07.047.Peer-Reviewed Original ResearchConceptsEnd-systolic volume indexLV end-systolic volume indexFunctional mitral regurgitationLV ejection fractionSeverity of MRMitral regurgitationVolume indexTenting areaIschemic cardiomyopathyMR gradeAnnulus areaVentricular end-systolic volume indexIschemic Heart Failure (STICH) trialSphericity indexHeart Failure TrialEffective regurgitant orifice areaPosterior leaflet angleMitral annulus areaMitral annulus diameterRegurgitant orifice areaSTICH trialSurgical treatmentEjection fractionFailure TrialTransesophageal echocardiography
2012
Influence of baseline left ventricular function on the clinical outcome of surgical ventricular reconstruction in patients with ischaemic cardiomyopathy
Oh JK, Velazquez EJ, Menicanti L, Pohost GM, Bonow RO, Lin G, Hellkamp AS, Ferrazzi P, Wos S, Rao V, Berman D, Bochenek A, Cherniavsky A, Rogowski J, Rouleau JL, Lee KL, Investigators O. Influence of baseline left ventricular function on the clinical outcome of surgical ventricular reconstruction in patients with ischaemic cardiomyopathy. European Heart Journal 2012, 34: 39-47. PMID: 22584648, PMCID: PMC3533917, DOI: 10.1093/eurheartj/ehs021.Peer-Reviewed Original ResearchConceptsEnd-systolic volume indexSurgical ventricular reconstructionRegional wall motion abnormalitiesWall motion abnormalitiesEjection fractionBetter LVEFIschemic cardiomyopathyVentricular reconstructionMotion abnormalitiesLV end-systolic volume indexMedian end-systolic volume indexBaseline left ventricular functionIschemic Heart Failure (STICH) trialEnd-diastolic volume indexVolume indexBaseline LV functionCoronary artery bypassHeart Failure TrialLeft ventricular functionClinical trial registrationLeft ventricular function parametersLV global functionVentricular function parametersCardiovascular magnetic resonanceML/m2Core Lab Analysis of Baseline Echocardiographic Studies in the STICH Trial and Recommendation for Use of Echocardiography in Future Clinical Trials
Oh JK, Pellikka PA, Panza JA, Biernat J, Attisano T, Manahan BG, Wiste HJ, Lin G, Lee K, Miller FA, Stevens S, Sopko G, She L, Velazquez EJ, Investigators S. Core Lab Analysis of Baseline Echocardiographic Studies in the STICH Trial and Recommendation for Use of Echocardiography in Future Clinical Trials. Journal Of The American Society Of Echocardiography 2012, 25: 327-336. PMID: 22227341, PMCID: PMC3310914, DOI: 10.1016/j.echo.2011.12.002.Peer-Reviewed Original ResearchConceptsEjection fractionEffective regurgitant orifice areaRegurgitant orifice areaIschemic cardiomyopathyClinical practiceVentricular end-systolic volume indexPulmonary artery systolic pressureEnd-systolic volume indexLeast moderate mitral regurgitationOrifice areaBaseline echocardiographic examinationBaseline echocardiographic findingsBaseline echocardiographic studyCore lab analysisCoronary artery bypassIschemic heart failureMean ejection fractionCoronary artery diseaseModerate mitral regurgitationUse of echocardiographyMitral inflow velocityEchocardiography core laboratoryFuture clinical trialsCore laboratory analysisMitral regurgitation severity
2010
STICH (Surgical Treatment for Ischemic Heart Failure) Trial Enrollment
Jones RH, White H, Velazquez EJ, Shaw LK, Pietrobon R, Panza JA, Bonow RO, Sopko G, O'Connor CM, Rouleau JL. STICH (Surgical Treatment for Ischemic Heart Failure) Trial Enrollment. Journal Of The American College Of Cardiology 2010, 56: 490-498. PMID: 20670760, PMCID: PMC3259709, DOI: 10.1016/j.jacc.2009.11.102.Peer-Reviewed Original ResearchConceptsLow-risk patientsSTICH trialRAR groupBaseline characteristicsCardiac surgeryIschemic cardiomyopathyHigh-risk patientsNumber of patientsCountry of enrollmentSTICH patientsDuke DatabankRandomization groupTrial enrollmentCardiovascular diseaseRisk differencePatientsClinical decisionTrialsSurgeryCardiomyopathyRiskBroader populationEnrollment performanceDeathThirty-second
2008
Detection of Left Ventricular Thrombus by Delayed-Enhancement Cardiovascular Magnetic Resonance Prevalence and Markers in Patients With Systolic Dysfunction
Weinsaft JW, Kim HW, Shah DJ, Klem I, Crowley AL, Brosnan R, James OG, Patel MR, Heitner J, Parker M, Velazquez EJ, Steenbergen C, Judd RM, Kim RJ. Detection of Left Ventricular Thrombus by Delayed-Enhancement Cardiovascular Magnetic Resonance Prevalence and Markers in Patients With Systolic Dysfunction. Journal Of The American College Of Cardiology 2008, 52: 148-157. PMID: 18598895, DOI: 10.1016/j.jacc.2008.03.041.Peer-Reviewed Original ResearchConceptsDelayed-enhancement cardiovascular magnetic resonanceCine cardiovascular magnetic resonanceLarge mural thrombusLeft ventricular thrombusSystolic dysfunctionVentricular thrombusMural thrombusMyocardial scarringRisk factorsTertiary care referral centerPrevalence of thrombusIndependent risk factorPresence of thrombusLogistic regression analysisCardiovascular magnetic resonanceThrombus prevalenceWorse LVEFIschemic etiologyLower LVEFLV thrombusEmbolic eventsReferral centerConsecutive patientsIschemic cardiomyopathyMultivariable analysis
2007
Polymorphisms in Adenosine Receptor Genes are Associated with Infarct Size in Patients with Ischemic Cardiomyopathy
Tang Z, Diamond MA, Chen J, Holly TA, Bonow RO, Dasgupta A, Hyslop T, Purzycki A, Wagner J, McNamara DM, Kukulski T, Wos S, Velazquez EJ, Ardlie K, Feldman AM. Polymorphisms in Adenosine Receptor Genes are Associated with Infarct Size in Patients with Ischemic Cardiomyopathy. Clinical Pharmacology & Therapeutics 2007, 82: 435-440. PMID: 17728764, DOI: 10.1038/sj.clpt.6100331.Peer-Reviewed Original ResearchMeSH Keywords3' Untranslated RegionsBase SequenceCardiomyopathiesCase-Control StudiesDNA Mutational AnalysisGene FrequencyGenetic Predisposition to DiseaseHeart VentriclesHumansMolecular Sequence DataMutationMyocardial InfarctionMyocardial IschemiaPhenotypePolymorphism, Single NucleotideReceptor, Adenosine A1Receptor, Adenosine A2AReceptor, Adenosine A3Risk FactorsSeverity of Illness IndexVentricular Function, LeftConceptsIschemic cardiomyopathyInfarct sizeAdenosine receptor geneReceptor geneGenetic variantsPopulation of patientsVentricular functionVentricular sizeIschemic preconditioningNormal controlsHeart responseAdenosine receptorsCardiomyopathyIschemiaPatientsIndividual responsesDNA samplesResponsePolymorphismTherapyInjuryGenesVariants
2002
Comparison of coronary artery bypass grafting versus medical therapy on long-term outcome in patients with ischemic cardiomyopathy (a 25-year experience from the Duke Cardiovascular Disease Databank)
O’Connor C, Velazquez EJ, Gardner LH, Smith PK, Newman MF, Landolfo KP, Lee KL, Califf RM, Jones RH. Comparison of coronary artery bypass grafting versus medical therapy on long-term outcome in patients with ischemic cardiomyopathy (a 25-year experience from the Duke Cardiovascular Disease Databank). The American Journal Of Cardiology 2002, 90: 101-107. PMID: 12106836, DOI: 10.1016/s0002-9149(02)02429-3.Peer-Reviewed Original ResearchMeSH KeywordsAgedCardiac CatheterizationComorbidityCoronary AngiographyCoronary Artery BypassCoronary Artery DiseaseDisease-Free SurvivalFemaleFollow-Up StudiesHeart FailureHumansMaleMiddle AgedOutcome and Process Assessment, Health CareSurvival AnalysisTimeTreatment OutcomeVentricular Dysfunction, LeftConceptsCoronary artery bypass surgeryLong-term outcomesMedical therapyCoronary diseaseIschemic cardiomyopathyNew York Heart Association class IILeft ventricular ejection fractionCox proportional hazards modelDuke University Medical CenterDays of catheterizationInitial cardiac catheterizationMedical therapy armObservational treatment comparisonsCoronary artery bypassHeart failure symptomsMedical therapy groupVentricular systolic dysfunctionArtery bypass surgeryVentricular ejection fractionCoronary artery diseaseEpicardial coronary vesselsProportional hazards modelUniversity Medical CenterCABG groupTherapy arm