2024
Heterogeneous gene expression during early arteriovenous fistula remodeling suggests that downregulation of metabolism predicts adaptive venous remodeling
Ohashi Y, Protack C, Aoyagi Y, Gonzalez L, Thaxton C, Zhang W, Kano M, Bai H, Yatsula B, Alves R, Hoshina K, Schneider E, Long X, Perry R, Dardik A. Heterogeneous gene expression during early arteriovenous fistula remodeling suggests that downregulation of metabolism predicts adaptive venous remodeling. Scientific Reports 2024, 14: 13287. PMID: 38858395, PMCID: PMC11164895, DOI: 10.1038/s41598-024-64075-8.Peer-Reviewed Original ResearchConceptsGene expression patternsArteriovenous fistula groupArteriovenous fistulaExpression patternsHeterogeneous gene expressionGene expression changesOutcomes of arteriovenous fistulaVenous remodelingArteriovenous fistula maturationPostoperative day 7Reduce patient morbidityRNA sequencingUpregulation of metabolismBioinformatics analysisGene expressionDownregulation of metabolismMetabolic pathwaysExpression changesGenesAVF maturationAVF remodelingFistula creationC57BL/6 miceClinical outcomesPatient morbidity
2023
An Evaluation of Sex-Based Differences in Surrogate Consent for Older Adults Undergoing Surgical Intervention
Nagarkatti N, Miller S, Ahuja V, Schneider E, Mohanty S, Kodadek L. An Evaluation of Sex-Based Differences in Surrogate Consent for Older Adults Undergoing Surgical Intervention. Journal Of Surgical Research 2023, 288: 246-251. PMID: 37030182, DOI: 10.1016/j.jss.2023.02.041.Peer-Reviewed Original ResearchConceptsPreoperative cognitive impairmentMale patientsCognitive impairmentSurrogate consentSurgeons National Surgical Quality Improvement ProgramNational Surgical Quality Improvement ProgramSurgical Quality Improvement ProgramPatients age 65Preoperative cognitive statusQuality Improvement ProgramHigh rateSex-based differencesFemale patientsPatient sexSurgical interventionStratified analysisFacets of medicineAge 75American CollegePatientsAge 65Cognitive statusDescriptive studyOlder adultsAge categoriesArterial Diameter and Percentage of Monocytes are Sex-Dependent Predictors of Early Arteriovenous Fistula Maturation
Satam K, Setia O, Moore M, Schneider E, Chaar C, Dardik A. Arterial Diameter and Percentage of Monocytes are Sex-Dependent Predictors of Early Arteriovenous Fistula Maturation. Annals Of Vascular Surgery 2023, 93: 128-136. PMID: 36812979, PMCID: PMC10277224, DOI: 10.1016/j.avsg.2023.01.052.Peer-Reviewed Original ResearchConceptsFistula maturationArteriovenous fistula maturationArterial diameterArteriovenous fistulaFistula creationBrachial artery diameterPrimary arteriovenous fistulaPercentage of neutrophilsPeak systolic velocityPercentage of monocytesBrachial-cephalic fistulaElectronic medical recordsSex differencesFistula utilizationInferior patencyPostoperative ultrasoundUnassisted maturationYears postprocedureSingle centerArtery diameterArterial inflowArterial velocitySystolic velocityMedical recordsMonocyte percentage
2021
Non-Operative Shoulder Dysfunction in the United States Military
Leggit J, Wu H, Janvrin M, Korona-Bailey J, Koehlmoos T, Schneider E. Non-Operative Shoulder Dysfunction in the United States Military. Military Medicine 2021, 188: e1003-e1009. PMID: 34865115, DOI: 10.1093/milmed/usab468.Peer-Reviewed Original ResearchConceptsMilitary Health SystemUpper arm injuriesShoulder dysfunctionForce readinessMilitary Health System Data RepositoryTreatment of shoulder dysfunctionService membersPhysical fitness domainActive duty military service membersDiagnosis of shoulderHealth services researchActive duty service membersType of careFiscal yearDuty service membersActive duty membersMilitary service membersTotal Force FitnessLaboratory test costsHealth servicesHealth systemRetrospective cohort studyFunctional limitationsNonoperative conditionsNonoperative careMethylation-based Cell-free DNA Signature for Early Detection of Pancreatic Cancer
Ying L, Sharma A, Chhoda A, Ruzgar N, Hasan N, Kwak R, Wolfgang CL, Wang TH, Kunstman JW, Salem RR, Wood LD, Iacobuzio-Donahue C, Schneider EB, Farrell JJ, Ahuja N. Methylation-based Cell-free DNA Signature for Early Detection of Pancreatic Cancer. Pancreas 2021, 50: 1267-1273. PMID: 34860810, DOI: 10.1097/mpa.0000000000001919.Peer-Reviewed Original Research
2019
Socioeconomically Distressed Communities Index independently predicts major adverse limb events after infrainguinal bypass in a national cohort
Hawkins R, Mehaffey J, Charles E, Kern J, Schneider E, Tracci M. Socioeconomically Distressed Communities Index independently predicts major adverse limb events after infrainguinal bypass in a national cohort. Journal Of Vascular Surgery 2019, 70: 1985-1993.e8. PMID: 31761106, DOI: 10.1016/j.jvs.2019.03.060.Peer-Reviewed Original ResearchConceptsDistressed Communities IndexMajor adverse limb eventsAdverse limb eventsInfrainguinal bypassGraft occlusionIndependent predictorsLimb eventsMajor adverse cardiovascular eventsLong-term maleAdverse cardiovascular eventsOperative risk factorsCritical limb ischemiaMore comorbid diseasesCare-related outcomesHealth care-related outcomesPrior amputationHospital mortalityCardiovascular eventsComorbid diseasesLimb ischemiaSurgical outcomesNational cohortVascular diseaseRisk factorsUnivariate analysisEffect of Travel Time for Thyroid Surgery on Treatment Cost and Morbidity
Ramirez A, Schneider E, Mehaffey J, Zeiger M, Hanks J, Smith P. Effect of Travel Time for Thyroid Surgery on Treatment Cost and Morbidity. The American Surgeon 2019, 85: 949-955. PMID: 31638505, DOI: 10.1177/000313481908500934.Peer-Reviewed Original ResearchConceptsHigh-volume centersThyroid surgeryPrimary outcomeHospital costsSingle high-volume centerMedian operative timeHealth care utilizationCertain patient populationsMultivariable regression modelingPatient's home addressHome addressPostoperative morbidityACS-NSQIPOperative timePatient populationUninsured statusThyroid diseaseEndocrine surgeryMorbidity riskThyroid proceduresSurgical careTime-related differencesPatient differencesDisease processPatientsCollecting sexual orientation and gender identity information in the emergency department : the divide between patient and provider perspectives
Kodadek LM, Peterson S, Shields RY, German D, Ranjit A, Snyder C, Schneider E, Lau BD, Haider AH. Collecting sexual orientation and gender identity information in the emergency department : the divide between patient and provider perspectives. Emergency Medicine Journal 2019, 36: 136. PMID: 30630837, DOI: 10.1136/emermed-2018-207669.Peer-Reviewed Original ResearchConceptsED cliniciansED providersClinical circumstancesGender identity informationMost clinical circumstancesInstitute of MedicinePatients' sexual orientationGender minority patientsED encountersEmergency departmentMinority patientsPatients' viewsPatientsAcademic centersSimilar careProvider perspectivesJoint CommissionPrior reportsDiscordant perspectivesRoutine collectionConstant comparative methodCliniciansPurposive sampleTherapeutic relationshipCare
2018
Assessment of Patient-Centered Approaches to Collect Sexual Orientation and Gender Identity Information in the Emergency Department
Haider A, Adler RR, Schneider E, Leitz T, Ranjit A, Ta C, Levine A, Harfouch O, Pelaez D, Kodadek L, Vail L, Snyder C, German D, Peterson S, Schuur JD, Lau BD. Assessment of Patient-Centered Approaches to Collect Sexual Orientation and Gender Identity Information in the Emergency Department. JAMA Network Open 2018, 1: e186506. PMID: 30646332, PMCID: PMC6324335, DOI: 10.1001/jamanetworkopen.2018.6506.Peer-Reviewed Original ResearchMeSH KeywordsAdultAttitude of Health PersonnelCohort StudiesData CollectionEmergency Medical ServicesEmergency Service, HospitalFemaleGender IdentityHealth PersonnelHumansMaleMedical RecordsMiddle AgedPatient SatisfactionPatient-Centered CareProfessional-Patient RelationsSexual and Gender MinoritiesSexual BehaviorUnited StatesYoung AdultConceptsGender minority patientsIllness severityMinority patientsGender identity informationOptimal patient-centered approachAssessment of patientsHigh patient satisfactionEmergency department settingPatient satisfaction measuresPatient-centered approachPatient-centered methodStakeholder advisory boardCohort studyED visitsED physiciansEligible adultsMean ageEmergency departmentPatient preferencesPatient satisfactionDepartment settingIntervention periodMAIN OUTCOMEPatientsSGM patientsPatient Presentations in Outpatient Settings
Zogg CK, Haring RS, Xu L, Canner JK, Ottesen TD, Salim A, Haider AH, Schneider EB. Patient Presentations in Outpatient Settings. Epidemiology 2018, 29: 885-894. PMID: 30063541, PMCID: PMC6167152, DOI: 10.1097/ede.0000000000000900.Peer-Reviewed Original ResearchConceptsInjury-specific factorsOutpatient settingHead traumaTrauma patientsEmergency departmentIndex outpatient visitAmbulatory care useHead trauma patientsEmergency department careOutpatient presentationClinic visitsIndex presentationOutpatient visitsOutpatient burdenCare useOutpatient casesIncidence ratePatient presentationCommercial ClaimsTrauma diagnosisSubsequent visitsAnnual burdenTrauma trendsDisease controlPatientsTowards diaspora-driven research capacity strengthening in low- and middle-income countries: results from India and Nepal
Varadaraj V, Ranjit A, Nwadiuko J, Canner J, Diener-West M, Schneider E, Thyagarajan S, Shrestha R, Nagarajan N. Towards diaspora-driven research capacity strengthening in low- and middle-income countries: results from India and Nepal. International Health 2018, 11: 221-228. PMID: 30307506, DOI: 10.1093/inthealth/ihy076.Peer-Reviewed Original ResearchAssociation Between Age and Patient‐Reported Changes in Voice and Swallowing After Thyroidectomy
Sahli Z, Canner J, Najjar O, Schneider E, Prescott J, Russell J, Tufano R, Zeiger M, Mathur A. Association Between Age and Patient‐Reported Changes in Voice and Swallowing After Thyroidectomy. The Laryngoscope 2018, 129: 519-524. PMID: 30194684, PMCID: PMC6344315, DOI: 10.1002/lary.27297.Peer-Reviewed Original ResearchConceptsSwallowing changesSwallowing alterationsRisk factorsIntraoperative recurrent laryngeal nerve monitoringIntact recurrent laryngeal nerveRecurrent laryngeal nerve monitoringPatient-reported voiceGastroesophageal reflux diseaseAdditional prospective studiesLaryngeal nerve monitoringRecurrent laryngeal nervePresence of malignancyImpact of ageInstitutional review boardIntact RLNReflux diseaseRLN injuryTotal thyroidectomyFrailty statusPatient ageConsecutive patientsFrailty indexRetrospective reviewLaryngeal nerveNerve monitoringPrognostic Impact of Serum Pancreastatin Following Chemoembolization for Neuroendocrine Tumors
Strosberg D, Schneider EB, Onesti J, Saunders N, Konda B, Shah M, Dillhoff M, Schmidt CR, Shirley LA. Prognostic Impact of Serum Pancreastatin Following Chemoembolization for Neuroendocrine Tumors. Annals Of Surgical Oncology 2018, 25: 3613-3620. PMID: 30182331, DOI: 10.1245/s10434-018-6741-x.Peer-Reviewed Original ResearchConceptsRepeat transarterial chemoembolizationMetastatic neuroendocrine tumorsTransarterial chemoembolizationPancreastatin levelsNeuroendocrine tumorsOverall survivalPrognostic impactImproved overall survivalProgressive liver diseaseFirst transarterial chemoembolizationWorse overall survivalUseful prognostic indicatorLong-term survivalPg/mLConclusionsFor patientsPost TACECarcinoid syndromeTACE treatmentLiver metastasesPatient demographicsImproved survivalLiver diseasePoor outcomePrognostic indicatorResultsA totalNeutrophil lymphocyte ratio and transarterial chemoembolization in neuroendocrine tumor metastases
McDermott SM, Saunders ND, Schneider EB, Strosberg D, Onesti J, Dillhoff M, Schmidt CR, Shirley LA. Neutrophil lymphocyte ratio and transarterial chemoembolization in neuroendocrine tumor metastases. Journal Of Surgical Research 2018, 232: 369-375. PMID: 30463743, DOI: 10.1016/j.jss.2018.06.058.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overChemoembolization, TherapeuticFemaleFollow-Up StudiesHumansKaplan-Meier EstimateLeukocyte CountLiver NeoplasmsLymphocytesMaleMiddle AgedNeuroendocrine TumorsNeutrophilsPreoperative PeriodPrognosisResponse Evaluation Criteria in Solid TumorsRetrospective StudiesYoung AdultConceptsMedian overall survivalMetastatic neuroendocrine tumorsTransarterial chemoembolizationOverall survivalNeuroendocrine tumorsSingle tertiary medical centerCancer-related treatmentTertiary medical centerNeuroendocrine tumor metastasesPotential treatment strategyElevated NLRLiver metastasesNLR valuesIndependent predictorsBlood workLymphocyte ratioEntire cohortTreatment strategiesPostprocedural careMedical CenterPatientsMultivariate analysisNLRTumor metastasisChemoembolizationManagement outcomes of diverticulitis and colitis in patients with active cancer
Horwood C, Wisler J, Byrd S, Woodling K, Schneider E, Rushing A. Management outcomes of diverticulitis and colitis in patients with active cancer. Surgery 2018, 164: 350-353. PMID: 29801733, DOI: 10.1016/j.surg.2018.03.010.Peer-Reviewed Original ResearchConceptsActive cancer diagnosisColonic emergenciesActive cancerNonoperative managementIntensive care unit admissionEmergent general surgeryCare unit admissionPreoperative risk factorsCancer diagnosisNon-operative managementCancer patient populationIntensive care unitNonoperative groupNonoperative patientsUnit admissionPostoperative complicationsCare unitColonic pathologyOperative groupSurgery consultOperative managementPatient populationCancer DatabaseRisk factorsGeneral surgeryConscious status is associated with the likelihood of trauma centre care and mortality in patients with moderate-to-severe traumatic brain injury
AlSulaim H, Haring R, Asemota A, Smart B, Canner J, Ejaz A, Efron D, Velopulos C, Haut E, Schneider E. Conscious status is associated with the likelihood of trauma centre care and mortality in patients with moderate-to-severe traumatic brain injury. Brain Injury 2018, 32: 784-793. PMID: 29561720, DOI: 10.1080/02699052.2018.1451658.Peer-Reviewed Original ResearchConceptsLoss of consciousnessNon-trauma centersTraumatic brain injuryTrauma centerBrain injuryHead/neck Abbreviated Injury Scale scoreNeck Abbreviated Injury Scale scoreLevel I/II trauma centersAbbreviated Injury Scale scoreSevere traumatic brain injuryInjury Scale scoreOdds of mortalityTrauma center careTC treatmentLogistic regression modelsHospital mortalityOlder patientsPatient demographicsPrimary outcomeInjury characteristicsNinth RevisionAIS scoreTBI outcomesPrevention criteriaClinical ModificationThe Epidemiology of Pediatric Head Injury Treated Outside of Hospital Emergency Departments
Zogg CK, Haring RS, Xu L, Canner JK, AlSulaim HA, Hashmi ZG, Salim A, Engineer LD, Haider AH, Bell JM, Schneider EB. The Epidemiology of Pediatric Head Injury Treated Outside of Hospital Emergency Departments. Epidemiology 2018, 29: 269-279. PMID: 29240568, PMCID: PMC5937022, DOI: 10.1097/ede.0000000000000791.Peer-Reviewed Original ResearchConceptsInjury-specific factorsPediatric patientsEmergency departmentOutpatient settingHead traumaAmbulatory care useEmergency department visitsEmergency department carePediatric head injuryTrauma-related deathsHospital emergency departmentHead trauma casesMarketScan MedicaidNationwide burdenOutpatient injuriesIndex visitDepartment visitsOutpatient burdenHead injuryCare useOutpatient careIncidence rateOutpatient casesTrauma casesCommercial ClaimsThe “mortality ascent”
Herrera-Escobar JP, Rios-Diaz AJ, Zogg CK, Wolf LL, Harlow A, Schneider EB, Cooper Z, Ordonez CA, Salim A, Haider AH. The “mortality ascent”. Journal Of Trauma And Acute Care Surgery 2018, 84: 139-145. PMID: 28930947, DOI: 10.1097/ta.0000000000001706.Peer-Reviewed Original ResearchConceptsUnstable trauma patientsLevel I TCsLevel II TCsHours postadmissionTrauma patientsLevel ILevel IIMortality riskHospital mortalityLog-binomial regression modelsNational Trauma Data BankComparable mortality riskHospital-level confoundersInjury Severity ScoreSystolic blood pressureAvailable treatment modalitiesTrauma Data BankSpecific risk factorsRisk-adjusted modelsBlood pressureHigher relative mortalityUnstable patientsBurn patientsSeverity scoreTreatment modalities
2017
One‐Hour Postoperative Parathyroid Hormone Levels Do Not Reliably Predict Hypocalcemia After Thyroidectomy
Sahli Z, Najafian A, Kahan S, Schneider E, Zeiger M, Mathur A. One‐Hour Postoperative Parathyroid Hormone Levels Do Not Reliably Predict Hypocalcemia After Thyroidectomy. World Journal Of Surgery 2017, 42: 2128-2133. PMID: 29290070, PMCID: PMC5991999, DOI: 10.1007/s00268-017-4444-2.Peer-Reviewed Original ResearchConceptsPostoperative parathyroid hormone levelsPg/mLParathyroid hormone levelsPostoperative PTHPTH levelsBiochemical hypocalcemiaTotal thyroidectomyCalcium supplementationProspective studyHormone levelsAppropriate calcium supplementationDefinitive study designPostoperative biochemical hypocalcemiaAdditional prospective studiesNormal PTH levelsPTH decreaseCompletion thyroidectomyConsecutive patientsSerum calciumLow PTHPTH 1HypocalcemiaIRB approvalThyroidectomyPTHFinancial Impact of Acute Kidney Injury After Cardiac Operations in the United States
Alshaikh H, Katz N, Gani F, Nagarajan N, Canner J, Kacker S, Najjar P, Higgins R, Schneider E. Financial Impact of Acute Kidney Injury After Cardiac Operations in the United States. The Annals Of Thoracic Surgery 2017, 105: 469-475. PMID: 29275828, DOI: 10.1016/j.athoracsur.2017.10.053.Peer-Reviewed Original ResearchConceptsAcute kidney injuryIndex hospitalization costsTotal index hospitalization costsIndex hospital costsCardiac operationsHospitalization costsKidney injuryDevelopment of AKISubstantial health care cost savingsClinical Modification diagnosis codesHealth care cost savingsMajor cardiac operationsCoronary artery bypassChronic renal failureNationwide Inpatient SampleMajor cardiac proceduresLong-term treatmentArtery bypassRenal failureValve replacementReplacement patientsAvoidable complicationsCardiac proceduresPatient morbidityDiagnosis codes