2002
BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma
Loukinov DI, Pugacheva E, Vatolin S, Pack SD, Moon H, Chernukhin I, Mannan P, Larsson E, Kanduri C, Vostrov AA, Cui H, Niemitz EL, Rasko JE, Docquier FM, Kistler M, Breen JJ, Zhuang Z, Quitschke WW, Renkawitz R, Klenova EM, Feinberg AP, Ohlsson R, Morse HC, Lobanenkov VV. BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma. Proceedings Of The National Academy Of Sciences Of The United States Of America 2002, 99: 6806-6811. PMID: 12011441, PMCID: PMC124484, DOI: 10.1073/pnas.092123699.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCCCTC-Binding FactorCloning, MolecularDNA MethylationDNA-Binding ProteinsGene ExpressionGenetic MarkersGenomic ImprintingHumansMaleMiceMolecular Sequence DataProtein Structure, TertiaryRepressor ProteinsSequence Homology, Amino AcidTestisTranscription FactorsZinc FingersConceptsMethylation marksSame DNA-binding domainMale germ cell developmentMale germ line developmentEpigenetic reprogramming eventsGerm line developmentDNA-binding domainDNA-binding potentialMale germ lineGerm cell developmentX-chromosome inactivationMethylation-sensitive insulatorInsulator proteinsParalogous genesDistinct aminoReprogramming eventsImprinting marksGene regulationChromosome inactivationGerm lineCTCF geneCTCF expressionCarboxy terminusCTCFCandidate proteins
2001
Loss of imprinting of insulin-like growth factor-II in Wilms' tumor commonly involves altered methylation but not mutations of CTCF or its binding site.
Cui H, Niemitz EL, Ravenel JD, Onyango P, Brandenburg SA, Lobanenkov VV, Feinberg AP. Loss of imprinting of insulin-like growth factor-II in Wilms' tumor commonly involves altered methylation but not mutations of CTCF or its binding site. Cancer Research 2001, 61: 4947-50. PMID: 11431321.Peer-Reviewed Original ResearchMeSH KeywordsAllelesBase SequenceBinding SitesCCCTC-Binding FactorDNA MethylationDNA-Binding ProteinsGene Expression Regulation, NeoplasticGenomic ImprintingHumansInsulin-Like Growth Factor IIMutationRepressor ProteinsReverse Transcriptase Polymerase Chain ReactionRNA, Long NoncodingRNA, MessengerRNA, UntranslatedTranscription FactorsWilms TumorConceptsLoss of imprintingH19 DMRMaternal alleleActive maternal alleleAberrant methylationTranscription factor CTCFInsulin-like growth factor II geneSilent maternal alleleGrowth factor II geneFactor II geneFactor CTCFTranscriptional silencingConsensus sitesCTCF geneNormal imprintingH19 geneCTCFIGF2 imprintingMaternal copyWilms tumorRegion upstreamCommon molecular abnormalityMethylationInsulin-like growth factor IIGenes