BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma
Loukinov DI, Pugacheva E, Vatolin S, Pack SD, Moon H, Chernukhin I, Mannan P, Larsson E, Kanduri C, Vostrov AA, Cui H, Niemitz EL, Rasko JE, Docquier FM, Kistler M, Breen JJ, Zhuang Z, Quitschke WW, Renkawitz R, Klenova EM, Feinberg AP, Ohlsson R, Morse HC, Lobanenkov VV. BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma. Proceedings Of The National Academy Of Sciences Of The United States Of America 2002, 99: 6806-6811. PMID: 12011441, PMCID: PMC124484, DOI: 10.1073/pnas.092123699.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCCCTC-Binding FactorCloning, MolecularDNA MethylationDNA-Binding ProteinsGene ExpressionGenetic MarkersGenomic ImprintingHumansMaleMiceMolecular Sequence DataProtein Structure, TertiaryRepressor ProteinsSequence Homology, Amino AcidTestisTranscription FactorsZinc FingersConceptsMethylation marksSame DNA-binding domainMale germ cell developmentMale germ line developmentEpigenetic reprogramming eventsGerm line developmentDNA-binding domainDNA-binding potentialMale germ lineGerm cell developmentX-chromosome inactivationMethylation-sensitive insulatorInsulator proteinsParalogous genesDistinct aminoReprogramming eventsImprinting marksGene regulationChromosome inactivationGerm lineCTCF geneCTCF expressionCarboxy terminusCTCFCandidate proteins