2020
Prospective, randomized, double-blind, placebo-controlled evaluation of the Pharmacokinetics, Safety and Efficacy of Recombinant Antithrombin Versus Placebo in Preterm Preeclampsia
Paidas MJ, Tita ATN, Macones GA, Saade GA, Ehrenkranz RA, Triche EW, Streisand JB, Lam GK, Magann EF, Lewis DF, Dombrowski MP, Werner EF, Branch DW, Habli MA, Grotegut CA, Silver RM, Longo SA, Amon E, Cleary K, How HY, Novotny SR, Grobman WA, Whiteman VE, Wing DA, Scifres CM, Sibai BM. Prospective, randomized, double-blind, placebo-controlled evaluation of the Pharmacokinetics, Safety and Efficacy of Recombinant Antithrombin Versus Placebo in Preterm Preeclampsia. American Journal Of Obstetrics And Gynecology 2020, 223: 739.e1-739.e13. PMID: 32780999, DOI: 10.1016/j.ajog.2020.08.004.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, IntravenousAdolescentAdultAntithrombin ProteinsCesarean SectionDelivery, ObstetricDouble-Blind MethodFemaleFetal DistressGestational AgeHumansInfant, Premature, DiseasesInfant, Small for Gestational AgeMiddle AgedNeonatal SepsisPerinatal MortalityPre-EclampsiaPregnancyPregnancy Trimester, SecondPregnancy Trimester, ThirdProspective StudiesRecombinant ProteinsYoung AdultConceptsRecombinant human antithrombinPreterm preeclampsiaExpectant managementMorbidity scoreHuman antithrombinPlacebo-controlled clinical trialPlacebo-controlled evaluationPlacebo-controlled trialMedian gestational ageMaternal complicationsVersus PlaceboFetal outcomesMaternal outcomesPreterm deliveryEndothelial dysfunctionSecondary outcomesSingleton pregnanciesStandard therapyLoading dosePrimary outcomeWeeks' gestationGestational ageContinuous infusionClinical trialsSaline infusion
2016
Comparing expectant management and spontaneous labor approaches in studying the effect of labor induction on cesarean delivery
Danilack VA, Triche EW, Dore DD, Muri JH, Phipps MG, Savitz DA. Comparing expectant management and spontaneous labor approaches in studying the effect of labor induction on cesarean delivery. Annals Of Epidemiology 2016, 26: 405-411.e1. PMID: 27211604, DOI: 10.1016/j.annepidem.2016.04.009.Peer-Reviewed Original ResearchConceptsCesarean deliveryLabor inductionExpectant managementRisk ratioWeek 34Week 37Comparison groupRisk of CDIntrauterine growth restrictionMother-newborn dyadsSpontaneous laborVaginal deliveryWeeks' gestationWeek 36Maternal ageSpontaneous onsetGrowth restrictionDiabetic disordersWeek 40High riskLower riskClinical practiceWeek 41Member hospitalsGestationPhysical Activity During Pregnancy and Subsequent Risk of Preeclampsia and Gestational Hypertension: A Case Control Study
Spracklen C, Ryckman K, Triche E, Saftlas A. Physical Activity During Pregnancy and Subsequent Risk of Preeclampsia and Gestational Hypertension: A Case Control Study. Maternal And Child Health Journal 2016, 20: 1193-1202. PMID: 26910608, PMCID: PMC5538351, DOI: 10.1007/s10995-016-1919-y.Peer-Reviewed Original ResearchConceptsRisk of preeclampsiaLeisure-time PAGestational hypertensionSedentary activitiesMedical chart reviewCase-control studyGestational hypertensiveObjectivePhysical activityPreeclampsia resultsPregnancy hypertensionPrepregnancy BMINormotensive womenChart reviewHypertension riskPreeclampsia riskSubsequent riskPreeclampsiaEpidemiologic studiesPA exposurePhysical activityMultinomial logistic regressionHypertensionControl studyDisease statusBirth records
2015
Recombinant Human Antithrombin in Pregnant Patients with Hereditary Antithrombin Deficiency: Integrated Analysis of Clinical Data
Paidas MJ, Triche EW, James AH, DeSancho M, Robinson C, Lazarchick J, Ornaghi S, Frieling J. Recombinant Human Antithrombin in Pregnant Patients with Hereditary Antithrombin Deficiency: Integrated Analysis of Clinical Data. American Journal Of Perinatology 2015, 33: 343-349. PMID: 26461927, DOI: 10.1055/s-0035-1564423.Peer-Reviewed Original ResearchConceptsRecombinant human antithrombinVenous thromboembolismPregnant patientsDoses of anticoagulationHigh VTE riskPostpartum venous thromboembolismHereditary antithrombin deficiencyHuman antithrombinOnset of laborAnticoagulation therapyVTE eventsVTE riskCesarean deliveryTherapy durationProphylactic dosesWeight heparinPeripartum periodClinical trialsClinical dataAntithrombin deficiencyPatientsBody weightIU/TherapyDosesFolic acid supplementation in early pregnancy and the risk of preeclampsia, small for gestational age offspring and preterm delivery
Martinussen MP, Bracken MB, Triche EW, Jacobsen GW, Risnes KR. Folic acid supplementation in early pregnancy and the risk of preeclampsia, small for gestational age offspring and preterm delivery. European Journal Of Obstetrics & Gynecology And Reproductive Biology 2015, 195: 94-99. PMID: 26500184, PMCID: PMC4684439, DOI: 10.1016/j.ejogrb.2015.09.022.Peer-Reviewed Original ResearchMeSH KeywordsAdultCohort StudiesFemaleFolic AcidHumansInfant, Low Birth WeightInfant, NewbornInfant, Small for Gestational AgeObesityOdds RatioPre-EclampsiaPregnancyPregnancy ComplicationsPregnancy Trimester, FirstPremature BirthProspective StudiesProtective FactorsRisk FactorsVitamin B ComplexYoung AdultConceptsFolic acid supplementationLow birth weightFolic acid intakePreterm birthAcid supplementationFirst trimesterLean mothersBirth weightAcid intakeEarly pregnancyOdds ratioGestational age offspringProspective cohort studyFolic acid supplementsFolic acid usePregnancy outcome dataRisk of preeclampsiaPossible protective effectMonths of pregnancyObese mothersPreterm deliveryCohort studyObstetric recordsAge offspringFolate intakePre-Pregnancy BMI, Gestational Weight Gain, and the Risk of Hypertensive Disorders of Pregnancy: A Cohort Study in Wuhan, China
Zhou A, Xiong C, Hu R, Zhang Y, Bassig BA, Triche E, Yang S, Qiu L, Zhang Y, Yao C, Xu S, Wang Y, Xia W, Qian Z, Zheng T, Zhang B. Pre-Pregnancy BMI, Gestational Weight Gain, and the Risk of Hypertensive Disorders of Pregnancy: A Cohort Study in Wuhan, China. PLOS ONE 2015, 10: e0136291. PMID: 26305565, PMCID: PMC4548954, DOI: 10.1371/journal.pone.0136291.Peer-Reviewed Original ResearchConceptsTotal gestational weight gainGestational weight gainRisk of HDPPre-pregnancy BMIRisk factorsHypertensive disordersCohort studyBMI gainEarly gestational weight gainMaternal pre-pregnancy BMIChinese womenWeight gainMultiple unconditional logistic regressionLive singleton pregnancyUnconditional logistic regressionNormal-weight counterpartsPutative risk factorsWeight control effortsSingleton pregnanciesMaternal deathsEarly pregnancyIOM recommendationsMedicine recommendationsElevated riskPregnancyCigarette smoking and emergency care utilization among asthmatic adults in the 2011 Asthma Call-back Survey
Khokhawalla S, Rosenthal S, Pearlman D, Triche E. Cigarette smoking and emergency care utilization among asthmatic adults in the 2011 Asthma Call-back Survey. Journal Of Asthma 2015, 52: 732-739. PMID: 25563058, DOI: 10.3109/02770903.2015.1004337.Peer-Reviewed Original ResearchConceptsAsthma Call-back SurveyUrgent visitsCall-back SurveyAsthmatic adultsFormer smokersEmergency departmentEmergency careCurrent smokersED visitsEmergency care useEmergency care visitsCessation of smokingCross-sectional study designEmergency care utilizationMultivariable logistic regressionPopulation attributable riskPopulation-based estimatesHealth care costsFormer smokingAdult asthmaticsCare visitsCurrent smokingCare utilizationSmoking statusCigarette smokingGestational weight gain among American Samoan women and its impact on delivery and infant outcomes
Hawley NL, Johnson W, Hart CN, Triche EW, Ah Ching J, Muasau-Howard B, McGarvey ST. Gestational weight gain among American Samoan women and its impact on delivery and infant outcomes. BMC Pregnancy And Childbirth 2015, 15: 10. PMID: 25643752, PMCID: PMC4324802, DOI: 10.1186/s12884-015-0451-1.Peer-Reviewed Original ResearchConceptsGestational weight gainEarly pregnancy weightTrimester weight gainThird trimester weight gainAmerican Samoan womenPregnancy weightWeight gainInfant outcomesSamoan womenSecond trimester weight gainExcess gestational weight gainExcessive gestational weight gainAppropriate gestational weight gainGreater gestational weight gainMedicine GWG guidelinesPrenatal care recordsOverweight/obeseOverweight/obesityExcess weight gainLevels of obesityOutcomes of interestBinary logistic regressionAdverse pregnancyInfant overweightLGA infants
2014
Genetic Predisposition to Dyslipidemia and Risk of Preeclampsia
Spracklen CN, Saftlas AF, Triche EW, Bjonnes A, Keating B, Saxena R, Breheny PJ, Dewan AT, Robinson JG, Hoh J, Ryckman KK. Genetic Predisposition to Dyslipidemia and Risk of Preeclampsia. American Journal Of Hypertension 2014, 28: 915-923. PMID: 25523295, PMCID: PMC4542907, DOI: 10.1093/ajh/hpu242.Peer-Reviewed Original ResearchMeSH KeywordsAdultBiomarkersBlood PressureCase-Control StudiesChi-Square DistributionCholesterol, HDLCholesterol, LDLDyslipidemiasFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansIowaLogistic ModelsMultivariate AnalysisOdds RatioPhenotypePolymorphism, Single NucleotidePre-EclampsiaPregnancyRisk FactorsTriglyceridesYoung Adult
2013
Cumulative exposure to paternal seminal fluid prior to conception and subsequent risk of preeclampsia
Saftlas A, Rubenstein L, Prater K, Harland K, Field E, Triche E. Cumulative exposure to paternal seminal fluid prior to conception and subsequent risk of preeclampsia. Journal Of Reproductive Immunology 2013, 101: 104-110. PMID: 24011785, DOI: 10.1016/j.jri.2013.07.006.Peer-Reviewed Original ResearchConceptsRisk of preeclampsiaVaginal exposureNulliparous womenImmune maladaptation hypothesisOdds of preeclampsiaMedical chart reviewPercentile of exposureBarrier contraceptive methodsCase-control studyVaginal sexual intercourseAllogeneic fetusChart reviewIowa womenPaternal HLAAntigen exposureImmune toleranceNormotensive controlsPaternal antigensMaternal tolerancePreeclampsia casesPreeclampsia riskSubsequent riskSeminal fluidLive birthsContraceptive useMaternal–fetal HLA sharing and preeclampsia: variation in effects by seminal fluid exposure in a case–control study of nulliparous women in Iowa
Triche E, Harland K, Field E, Rubenstein L, Saftlas A. Maternal–fetal HLA sharing and preeclampsia: variation in effects by seminal fluid exposure in a case–control study of nulliparous women in Iowa. Journal Of Reproductive Immunology 2013, 101: 111-119. PMID: 23998333, PMCID: PMC4060772, DOI: 10.1016/j.jri.2013.06.004.Peer-Reviewed Original ResearchConceptsCase-control studyHLA sharingSemen exposureNulliparous womenClass IHLA typingComplete HLA typingMaternal-fetal histocompatibilityOdds of preeclampsiaMother-baby pairsHLA-A matchingVaginal exposureNormotensive controlsSuccessful pregnancyPreeclampsia casesContraceptive usePreeclampsiaEligibility criteriaFluid exposureIngestion practicesClass IIMultivariate modelStudy sampleExposure historyType of practiceExploring the Role of Antithrombin Replacement for the Treatment of Preeclampsia: A Prospective Randomized Evaluation of the Safety and Efficacy of Recombinant Antithrombin in Very Preterm Preeclampsia (PRESERVE‐1)
Paidas MJ, Sibai BM, Triche EW, Frieling J, Lowry S, Group T. Exploring the Role of Antithrombin Replacement for the Treatment of Preeclampsia: A Prospective Randomized Evaluation of the Safety and Efficacy of Recombinant Antithrombin in Very Preterm Preeclampsia (PRESERVE‐1). American Journal Of Reproductive Immunology 2013, 69: 539-544. PMID: 23444920, DOI: 10.1111/aji.12091.Peer-Reviewed Original ResearchConceptsProspective Randomized EvaluationAntithrombin replacementWeeks' gestationRandomized EvaluationRecombinant antithrombinTreatment of preeclampsiaRecombinant human ATExpectant managementPreterm preeclampsiaPrimary endpointMaternal indicationsGestational ageStudy enrollmentAT therapyPreeclampsia studyPreeclampsiaGestationHuman ATAT replacementPharmacokinetic activityAntithrombinEfficacySafetyLaboratory assaysDelivery
2012
Implementing Provider‐based Sampling for the National Children's Study: Opportunities and Challenges
Belanger K, Buka S, Cherry DC, Dudley DJ, Elliott MR, Hale DE, Hertz‐Picciotto I, Illuzzi JL, Paneth N, Robbins JM, Triche EW, Bracken MB. Implementing Provider‐based Sampling for the National Children's Study: Opportunities and Challenges. Paediatric And Perinatal Epidemiology 2012, 27: 20-26. PMID: 23215706, DOI: 10.1111/ppe.12005.Peer-Reviewed Original ResearchConceptsNational Children's StudyProvider-based samplingChildren's StudyNational cohort studyPrenatal care providersNational probability sampleType of providerProbability sampleCohort studyPrenatal careCare providersChild healthProvider groupsAge 21Risk estimatesPrimary sampling unitsWomenBirthProvidersHealthSampling frameSecondary sampling unitsPregnancyNumber of strategiesUteroGenome-wide association study identifies a maternal copy-number deletion in PSG11 enriched among preeclampsia patients
Zhao L, Triche EW, Walsh KM, Bracken MB, Saftlas AF, Hoh J, Dewan AT. Genome-wide association study identifies a maternal copy-number deletion in PSG11 enriched among preeclampsia patients. BMC Pregnancy And Childbirth 2012, 12: 61. PMID: 22748001, PMCID: PMC3476390, DOI: 10.1186/1471-2393-12-61.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesCopy number variantsSingle nucleotide polymorphismsSNP candidatesCopy number deletionAssociation studiesGenome-wide scanLimited DNA quantitiesQuantitative real-time PCRAffymetrix SNP 6.0 microarraysGenomic regionsOnly deletionPSG11 geneReal-time PCRDeleterious natureMaternal single nucleotide polymorphismsNucleotide polymorphismsGenetic contributionDeletionDNA quantityCase-control datasetSignificance thresholdCNV callsPSG11GenesFetal growth and later maternal death, cardiovascular disease and diabetes
LYKKE JA, PAIDAS MJ, TRICHE EW, LANGHOFF‐ROOS J. Fetal growth and later maternal death, cardiovascular disease and diabetes. Acta Obstetricia Et Gynecologica Scandinavica 2012, 91: 503-510. PMID: 22372730, DOI: 10.1111/j.1600-0412.2011.01355.x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBirth WeightCardiovascular DiseasesCohort StudiesDenmarkDiabetes MellitusFemaleFetal DevelopmentFollow-Up StudiesHealth Status IndicatorsHumansInfant, NewbornMiddle AgedMortality, PrematurePregnancyProportional Hazards ModelsReference StandardsRegistriesRetrospective StudiesRiskYoung AdultConceptsSubsequent maternal deathIschemic heart diseaseFetal growthPonderal indexMaternal deathsStandardized birthweightHeart diseaseCardiovascular diseaseSubsequent mortalityCox proportional hazards modelFirst singleton deliverySmaller risk estimatesSubsequent diabetes mellitusRetrospective cohort studyProportional hazards modelCardiovascular morbidityPregnancy complicationsCohort studySingleton deliveriesDiabetes mellitusGestational ageLow birthweightPrimary exposureSubsequent riskEarly death
2011
Changes in Sexual Risk Behavior Before and After HIV Seroconversion in Southern African Women Enrolled in a HIV Prevention Trial
Venkatesh K, de Bruyn G, Mayer K, Cheng H, Blanchard K, Ramjee G, Chipato T, Triche E, Padian N, van der Straten A. Changes in Sexual Risk Behavior Before and After HIV Seroconversion in Southern African Women Enrolled in a HIV Prevention Trial. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2011, 57: 435-441. PMID: 21546849, DOI: 10.1097/qai.0b013e318220379b.Peer-Reviewed Original ResearchConceptsSexual risk behaviorsHIV seroconversionRisk behaviorsStudy visitSouthern African womenAnal sexSex partnersCondom useConsistent male condom useImproving Reproductive HealthHIV prevention trialsMale sex partnersMale condom useConsistent condom useSexual behaviorEpisodes of sexAfrican womenSecondary preventionHIV infectionHIV testingHIV statusPrevention trialsAfrica trialSeroconversionFemale condomSexual Risk Behaviors Among HIV-Infected South African Men and Women with Their Partners in a Primary Care Program: Implications for Couples-Based Prevention
Venkatesh K, de Bruyn G, Lurie M, Modisenyane T, Triche E, Gray G, Welte A, Martinson N. Sexual Risk Behaviors Among HIV-Infected South African Men and Women with Their Partners in a Primary Care Program: Implications for Couples-Based Prevention. AIDS And Behavior 2011, 16: 139-150. PMID: 21476005, PMCID: PMC3184366, DOI: 10.1007/s10461-011-9941-y.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-Retroviral AgentsBlack PeopleCD4 Lymphocyte CountCross-Sectional StudiesFamily CharacteristicsFemaleHIV InfectionsHumansMaleMiddle AgedPrevalencePrimary Health CareRisk-TakingSelf DisclosureSexual BehaviorSexual PartnersSocioeconomic FactorsSouth AfricaSurveys and QuestionnairesUrban PopulationYoung AdultConceptsHIV-positive partnerStatus unknown partnersSexual risk behaviorsPrimary care programsAntiretroviral therapyRisk behaviorsSouth African menCare programPartner's HIV statusAfrican menUnknown partnersActive HIVHIV statusHIV preventionHIVSex partnersUnprotected sexSex actsPreventionSexual behaviorMonthsWomenSexMenTherapyPrenatal Factors for Childhood Blood Pressure Mediated by Intrauterine and/or Childhood Growth?
Wen X, Triche E, Hogan J, Shenassa E, Buka S. Prenatal Factors for Childhood Blood Pressure Mediated by Intrauterine and/or Childhood Growth? Pediatrics 2011, 127: e713-e721. PMID: 21300676, PMCID: PMC3065147, DOI: 10.1542/peds.2010-2000.Peer-Reviewed Original ResearchConceptsOffspring systolic blood pressureSystolic blood pressureIntrauterine growth restrictionPregnancy weight gainBlood pressureYears of ageMaternal smokingPrenatal factorsChildhood growthPrepregnancy BMIBMI trajectoriesChildhood systolic blood pressureChildren's systolic blood pressureMaternal pregnancy weight gainWeight gainChildhood BMI trajectoriesHeavy maternal smokingOffspring blood pressureChildhood blood pressureMother-child pairsCollaborative Perinatal ProjectChronic hypertensionObstetric formPreeclampsia-eclampsiaChildhood BMI
2010
Growth of infants born to HIV‐infected women in South Africa according to maternal and infant characteristics
Venkatesh K, Lurie M, Triche E, De Bruyn G, Harwell J, McGarvey S, Gray G. Growth of infants born to HIV‐infected women in South Africa according to maternal and infant characteristics. Tropical Medicine And International Health 2010, 15: 1364-1374. PMID: 20955499, DOI: 10.1111/j.1365-3156.2010.02634.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-HIV AgentsBody HeightBody WeightCD4 Lymphocyte CountEpidemiologic MethodsFemaleGrowth DisordersHIV InfectionsHumansInfant FormulaInfant Nutritional Physiological PhenomenaInfant, NewbornInfectious Disease Transmission, VerticalMaleMaternal AgeNevirapinePregnancyPregnancy Complications, InfectiousViral LoadYoung AdultZidovudineConceptsMaternal CD4 cell countMonths of ageCD4 cell countUninfected infantsFormula feedingPremature birthGastrointestinal infectionsLower maternal CD4 cell countMultivariable Cox proportional hazards modelsCell countZ-scoreCox proportional hazards modelAdvanced HIV diseaseInfant HIV infectionLow maternal ageAppropriate antiretroviral therapyGrowth of infantsProportional hazards modelFunction of infantsMother-infant dyadsAntiretroviral therapyHIV diseaseHIV infectionMaternal ageMaternal characteristicsSpeed- and cane-related alterations in gait parameters in individuals with multiple sclerosis
Gianfrancesco M, Triche E, Fawcett J, Labas M, Patterson T, Lo A. Speed- and cane-related alterations in gait parameters in individuals with multiple sclerosis. Gait & Posture 2010, 33: 140-142. PMID: 20952198, DOI: 10.1016/j.gaitpost.2010.09.016.Peer-Reviewed Original ResearchConceptsGait parametersPreferred speedMultiple sclerosisGait impairmentMS populationBilateral coordinationAdditional trialsStance timeMS participantsCane useSwing timeStride lengthDouble supportDaily activitiesStep length ratioSingle supportAssistive devicesParticipantsIndividualsSclerosisMaximal speedImpairmentTrialsDaily