2018
Gene-Centric Analysis of Preeclampsia Identifies Maternal Association at PLEKHG1
Gray KJ, Kovacheva VP, Mirzakhani H, Bjonnes AC, Almoguera B, DeWan AT, Triche EW, Saftlas AF, Hoh J, Bodian DL, Klein E, Huddleston KC, Ingles SA, Lockwood CJ, Hakonarson H, McElrath TF, Murray JC, Wilson ML, Norwitz ER, Karumanchi SA, Bateman BT, Keating BJ, Saxena R. Gene-Centric Analysis of Preeclampsia Identifies Maternal Association at PLEKHG1. Hypertension 2018, 72: 408-416. PMID: 29967039, PMCID: PMC6043396, DOI: 10.1161/hypertensionaha.117.10688.Peer-Reviewed Original Research
2016
Physical Activity During Pregnancy and Subsequent Risk of Preeclampsia and Gestational Hypertension: A Case Control Study
Spracklen C, Ryckman K, Triche E, Saftlas A. Physical Activity During Pregnancy and Subsequent Risk of Preeclampsia and Gestational Hypertension: A Case Control Study. Maternal And Child Health Journal 2016, 20: 1193-1202. PMID: 26910608, PMCID: PMC5538351, DOI: 10.1007/s10995-016-1919-y.Peer-Reviewed Original ResearchConceptsRisk of preeclampsiaLeisure-time PAGestational hypertensionSedentary activitiesMedical chart reviewCase-control studyGestational hypertensiveObjectivePhysical activityPreeclampsia resultsPregnancy hypertensionPrepregnancy BMINormotensive womenChart reviewHypertension riskPreeclampsia riskSubsequent riskPreeclampsiaEpidemiologic studiesPA exposurePhysical activityMultinomial logistic regressionHypertensionControl studyDisease statusBirth records
2014
Genetic Predisposition to Dyslipidemia and Risk of Preeclampsia
Spracklen CN, Saftlas AF, Triche EW, Bjonnes A, Keating B, Saxena R, Breheny PJ, Dewan AT, Robinson JG, Hoh J, Ryckman KK. Genetic Predisposition to Dyslipidemia and Risk of Preeclampsia. American Journal Of Hypertension 2014, 28: 915-923. PMID: 25523295, PMCID: PMC4542907, DOI: 10.1093/ajh/hpu242.Peer-Reviewed Original ResearchMeSH KeywordsAdultBiomarkersBlood PressureCase-Control StudiesChi-Square DistributionCholesterol, HDLCholesterol, LDLDyslipidemiasFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansIowaLogistic ModelsMultivariate AnalysisOdds RatioPhenotypePolymorphism, Single NucleotidePre-EclampsiaPregnancyRisk FactorsTriglyceridesYoung Adult
2013
Cumulative exposure to paternal seminal fluid prior to conception and subsequent risk of preeclampsia
Saftlas A, Rubenstein L, Prater K, Harland K, Field E, Triche E. Cumulative exposure to paternal seminal fluid prior to conception and subsequent risk of preeclampsia. Journal Of Reproductive Immunology 2013, 101: 104-110. PMID: 24011785, DOI: 10.1016/j.jri.2013.07.006.Peer-Reviewed Original ResearchConceptsRisk of preeclampsiaVaginal exposureNulliparous womenImmune maladaptation hypothesisOdds of preeclampsiaMedical chart reviewPercentile of exposureBarrier contraceptive methodsCase-control studyVaginal sexual intercourseAllogeneic fetusChart reviewIowa womenPaternal HLAAntigen exposureImmune toleranceNormotensive controlsPaternal antigensMaternal tolerancePreeclampsia casesPreeclampsia riskSubsequent riskSeminal fluidLive birthsContraceptive useMaternal–fetal HLA sharing and preeclampsia: variation in effects by seminal fluid exposure in a case–control study of nulliparous women in Iowa
Triche E, Harland K, Field E, Rubenstein L, Saftlas A. Maternal–fetal HLA sharing and preeclampsia: variation in effects by seminal fluid exposure in a case–control study of nulliparous women in Iowa. Journal Of Reproductive Immunology 2013, 101: 111-119. PMID: 23998333, PMCID: PMC4060772, DOI: 10.1016/j.jri.2013.06.004.Peer-Reviewed Original ResearchConceptsCase-control studyHLA sharingSemen exposureNulliparous womenClass IHLA typingComplete HLA typingMaternal-fetal histocompatibilityOdds of preeclampsiaMother-baby pairsHLA-A matchingVaginal exposureNormotensive controlsSuccessful pregnancyPreeclampsia casesContraceptive usePreeclampsiaEligibility criteriaFluid exposureIngestion practicesClass IIMultivariate modelStudy sampleExposure historyType of practice
2012
Correction of Systematic Bias in Ultrasound Dating in Studies of Small-for-Gestational-Age Birth: An Example From the Iowa Health in Pregnancy Study
Harland K, Saftlas A, Wallis A, Yankowitz J, Triche E, Zimmerman M. Correction of Systematic Bias in Ultrasound Dating in Studies of Small-for-Gestational-Age Birth: An Example From the Iowa Health in Pregnancy Study. American Journal Of Epidemiology 2012, 176: 443-455. PMID: 22886591, PMCID: PMC3499119, DOI: 10.1093/aje/kws120.Peer-Reviewed Original ResearchConceptsLast menstrual periodUltrasound gestational ageGestational ageSGA birthEarly ultrasoundPreterm deliveryPopulation-based case-control studyFirst trimester vaginal bleedingFirst trimester prenatal careGestational age fetusesGestational-age birthsCase-control studyStandard guidelinesMultivariable linear regressionDifferent study populationsVaginal bleedingGestational durationSGA fetusesSGA subjectsPrenatal careMaternal ageMenstrual periodPregnancy StudyStudy populationUnadjusted modelsGenome-wide association study identifies a maternal copy-number deletion in PSG11 enriched among preeclampsia patients
Zhao L, Triche EW, Walsh KM, Bracken MB, Saftlas AF, Hoh J, Dewan AT. Genome-wide association study identifies a maternal copy-number deletion in PSG11 enriched among preeclampsia patients. BMC Pregnancy And Childbirth 2012, 12: 61. PMID: 22748001, PMCID: PMC3476390, DOI: 10.1186/1471-2393-12-61.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesCopy number variantsSingle nucleotide polymorphismsSNP candidatesCopy number deletionAssociation studiesGenome-wide scanLimited DNA quantitiesQuantitative real-time PCRAffymetrix SNP 6.0 microarraysGenomic regionsOnly deletionPSG11 geneReal-time PCRDeleterious natureMaternal single nucleotide polymorphismsNucleotide polymorphismsGenetic contributionDeletionDNA quantityCase-control datasetSignificance thresholdCNV callsPSG11Genes
2010
PDE11A associations with asthma: Results of a genome-wide association scan
DeWan AT, Triche EW, Xu X, Hsu LI, Zhao C, Belanger K, Hellenbrand K, Willis-Owen SA, Moffatt M, Cookson WO, Himes BE, Weiss ST, Gauderman WJ, Baurley JW, Gilliland F, Wilk JB, O’Connor G, Strachan DP, Hoh J, Bracken MB. PDE11A associations with asthma: Results of a genome-wide association scan. Journal Of Allergy And Clinical Immunology 2010, 126: 871-873.e9. PMID: 20920776, PMCID: PMC3133448, DOI: 10.1016/j.jaci.2010.06.051.Peer-Reviewed Original Research
2009
Hypertensive Pregnancy Disorders and Subsequent Cardiovascular Morbidity and Type 2 Diabetes Mellitus in the Mother
Lykke JA, Langhoff-Roos J, Sibai BM, Funai EF, Triche EW, Paidas MJ. Hypertensive Pregnancy Disorders and Subsequent Cardiovascular Morbidity and Type 2 Diabetes Mellitus in the Mother. Hypertension 2009, 53: 944-951. PMID: 19433776, DOI: 10.1161/hypertensionaha.109.130765.Peer-Reviewed Original ResearchMeSH KeywordsAdultCardiovascular DiseasesCase-Control StudiesCohort StudiesDenmarkDiabetes Mellitus, Type 2FemaleHumansHypertension, Pregnancy-InducedIncidencePre-EclampsiaPregnancyPregnancy OutcomePregnancy RatePregnancy, High-RiskPremature BirthProbabilityProportional Hazards ModelsRegistriesSeverity of Illness IndexYoung AdultConceptsType 2 diabetes mellitusSubsequent type 2 diabetes mellitusHypertensive pregnancy disordersSubsequent cardiovascular eventsDiabetes mellitusGestational hypertensionSevere preeclampsiaPregnancy disordersSubsequent hypertensionCardiovascular eventsRegistry-based cohort studyConsecutive singleton deliveriesSubsequent cardiovascular morbidityCongestive heart failureIschemic heart diseaseCardiovascular morbidityPlacental abruptionPreterm deliveryThromboembolic eventsCohort studyMild preeclampsiaSingleton deliveriesHeart failureSubsequent thromboembolismGestational age
2003
Asthma symptoms, severity, and drug therapy: a prospective study of effects on 2205 pregnancies.
Bracken MB, Triche EW, Belanger K, Saftlas A, Beckett WS, Leaderer BP. Asthma symptoms, severity, and drug therapy: a prospective study of effects on 2205 pregnancies. Obstetrics And Gynecology 2003, 102: 739-52. PMID: 14551004, DOI: 10.1016/s0029-7844(03)00621-5.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-Asthmatic AgentsAnti-Inflammatory AgentsAsthmaBirth WeightCase-Control StudiesConnecticutFemaleFetal Growth RetardationFetal Membranes, Premature RuptureHumansInfant, Low Birth WeightInfant, NewbornMassachusettsPregnancyPregnancy ComplicationsPregnancy OutcomeProspective StudiesRisk FactorsSeverity of Illness IndexSteroidsTheophyllineConceptsAsthma symptomsOral steroidsAsthma diagnosisPreterm deliveryPregnant womenHistory of asthmaIntrauterine growth restrictionIUGR infantsAsthma guidelinesAsthma historyController medicationsModerate asthmaAsthma therapyPregnant patientsSymptomatic patientsAsthma severityFetal effectsSymptomatic womenProspective studyDrug therapyGrowth restrictionAsthmaSymptomsMedicationsDiagnosis