2020
Prospective, randomized, double-blind, placebo-controlled evaluation of the Pharmacokinetics, Safety and Efficacy of Recombinant Antithrombin Versus Placebo in Preterm Preeclampsia
Paidas MJ, Tita ATN, Macones GA, Saade GA, Ehrenkranz RA, Triche EW, Streisand JB, Lam GK, Magann EF, Lewis DF, Dombrowski MP, Werner EF, Branch DW, Habli MA, Grotegut CA, Silver RM, Longo SA, Amon E, Cleary K, How HY, Novotny SR, Grobman WA, Whiteman VE, Wing DA, Scifres CM, Sibai BM. Prospective, randomized, double-blind, placebo-controlled evaluation of the Pharmacokinetics, Safety and Efficacy of Recombinant Antithrombin Versus Placebo in Preterm Preeclampsia. American Journal Of Obstetrics And Gynecology 2020, 223: 739.e1-739.e13. PMID: 32780999, DOI: 10.1016/j.ajog.2020.08.004.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, IntravenousAdolescentAdultAntithrombin ProteinsCesarean SectionDelivery, ObstetricDouble-Blind MethodFemaleFetal DistressGestational AgeHumansInfant, Premature, DiseasesInfant, Small for Gestational AgeMiddle AgedNeonatal SepsisPerinatal MortalityPre-EclampsiaPregnancyPregnancy Trimester, SecondPregnancy Trimester, ThirdProspective StudiesRecombinant ProteinsYoung AdultConceptsRecombinant human antithrombinPreterm preeclampsiaExpectant managementMorbidity scoreHuman antithrombinPlacebo-controlled clinical trialPlacebo-controlled evaluationPlacebo-controlled trialMedian gestational ageMaternal complicationsVersus PlaceboFetal outcomesMaternal outcomesPreterm deliveryEndothelial dysfunctionSecondary outcomesSingleton pregnanciesStandard therapyLoading dosePrimary outcomeWeeks' gestationGestational ageContinuous infusionClinical trialsSaline infusion
2019
Development and Validation of a Risk Prediction Model for Cesarean Delivery After Labor Induction
Danilack VA, Hutcheon JA, Triche EW, Dore DD, Muri JH, Phipps MG, Savitz DA. Development and Validation of a Risk Prediction Model for Cesarean Delivery After Labor Induction. Journal Of Women's Health 2019, 29: 656-669. PMID: 31657668, PMCID: PMC8935479, DOI: 10.1089/jwh.2019.7822.Peer-Reviewed Original ResearchConceptsLabor inductionCesarean deliveryHistory of herpesTerm labor inductionInternal validationExcessive fetal growthBetter risk stratificationExternal validation cohortVariables gestational ageRisk prediction modelStart of inductionRisk stratificationTime of inductionDevelopment cohortValidation cohortMaternal ageFetal growthMaternal raceMedical indicationsWoman's riskU.S. hospitalsCharacteristic curveHospitalCohortInduction
2018
Gene-Centric Analysis of Preeclampsia Identifies Maternal Association at PLEKHG1
Gray KJ, Kovacheva VP, Mirzakhani H, Bjonnes AC, Almoguera B, DeWan AT, Triche EW, Saftlas AF, Hoh J, Bodian DL, Klein E, Huddleston KC, Ingles SA, Lockwood CJ, Hakonarson H, McElrath TF, Murray JC, Wilson ML, Norwitz ER, Karumanchi SA, Bateman BT, Keating BJ, Saxena R. Gene-Centric Analysis of Preeclampsia Identifies Maternal Association at PLEKHG1. Hypertension 2018, 72: 408-416. PMID: 29967039, PMCID: PMC6043396, DOI: 10.1161/hypertensionaha.117.10688.Peer-Reviewed Original Research
2016
Genetic predisposition to elevated levels of C-reactive protein is associated with a decreased risk for preeclampsia
Spracklen CN, Smith CJ, Saftlas AF, Triche EW, Bjonnes A, Keating BJ, Saxena R, Breheny PJ, Dewan AT, Robinson JG, Hoh J, Ryckman KK. Genetic predisposition to elevated levels of C-reactive protein is associated with a decreased risk for preeclampsia. Hypertension In Pregnancy 2016, 36: 30-35. PMID: 27657194, PMCID: PMC5538572, DOI: 10.1080/10641955.2016.1223303.Peer-Reviewed Original ResearchConceptsC-reactive proteinGenetic risk scoreRisk of preeclampsiaBody mass indexGenetic predispositionCRP levelsPreeclampsia casesRisk scoreCRP genetic risk scoreElevated C-reactive proteinLeisure-time physical activityBlood CRP levelsIndependent replication populationMarkers of preeclampsiaElevated levelsMedical chart reviewLive birth certificatesLogistic regression analysisInverse linear trendChart reviewIowa womenNormotensive controlsDecreased riskMass indexPhysical activityComparing expectant management and spontaneous labor approaches in studying the effect of labor induction on cesarean delivery
Danilack VA, Triche EW, Dore DD, Muri JH, Phipps MG, Savitz DA. Comparing expectant management and spontaneous labor approaches in studying the effect of labor induction on cesarean delivery. Annals Of Epidemiology 2016, 26: 405-411.e1. PMID: 27211604, DOI: 10.1016/j.annepidem.2016.04.009.Peer-Reviewed Original ResearchConceptsCesarean deliveryLabor inductionExpectant managementRisk ratioWeek 34Week 37Comparison groupRisk of CDIntrauterine growth restrictionMother-newborn dyadsSpontaneous laborVaginal deliveryWeeks' gestationWeek 36Maternal ageSpontaneous onsetGrowth restrictionDiabetic disordersWeek 40High riskLower riskClinical practiceWeek 41Member hospitalsGestationdbPEC: a comprehensive literature-based database for preeclampsia related genes and phenotypes
Uzun A, Triche EW, Schuster J, Dewan AT, Padbury JF. dbPEC: a comprehensive literature-based database for preeclampsia related genes and phenotypes. Database 2016, 2016: baw006. PMID: 26946289, PMCID: PMC4779341, DOI: 10.1093/database/baw006.Peer-Reviewed Original ResearchPhysical Activity During Pregnancy and Subsequent Risk of Preeclampsia and Gestational Hypertension: A Case Control Study
Spracklen C, Ryckman K, Triche E, Saftlas A. Physical Activity During Pregnancy and Subsequent Risk of Preeclampsia and Gestational Hypertension: A Case Control Study. Maternal And Child Health Journal 2016, 20: 1193-1202. PMID: 26910608, PMCID: PMC5538351, DOI: 10.1007/s10995-016-1919-y.Peer-Reviewed Original ResearchConceptsRisk of preeclampsiaLeisure-time PAGestational hypertensionSedentary activitiesMedical chart reviewCase-control studyGestational hypertensiveObjectivePhysical activityPreeclampsia resultsPregnancy hypertensionPrepregnancy BMINormotensive womenChart reviewHypertension riskPreeclampsia riskSubsequent riskPreeclampsiaEpidemiologic studiesPA exposurePhysical activityMultinomial logistic regressionHypertensionControl studyDisease statusBirth records
2015
The Rising Burden of Preeclampsia in the United States Impacts Both Maternal and Child Health
Shih T, Peneva D, Xu X, Sutton A, Triche E, Ehrenkranz RA, Paidas M, Stevens W. The Rising Burden of Preeclampsia in the United States Impacts Both Maternal and Child Health. American Journal Of Perinatology 2015, 33: 329-338. PMID: 26479171, DOI: 10.1055/s-0035-1564881.Peer-Reviewed Original ResearchConceptsEarly-onset preeclampsiaNumerous adverse health consequencesHealth consequencesConsiderable perinatal morbidityAdverse health consequencesEstimates of burdenSeverity of outcomePerinatal morbidityPreterm deliveryPreterm birthTerm pregnancyMaternal mortalityUS incidencePreeclampsiaChild healthEffective treatmentEconomic burdenRising BurdenSocial burdenHealth careBurdenMortalityUnited StatesHealthMothersRecombinant Human Antithrombin in Pregnant Patients with Hereditary Antithrombin Deficiency: Integrated Analysis of Clinical Data
Paidas MJ, Triche EW, James AH, DeSancho M, Robinson C, Lazarchick J, Ornaghi S, Frieling J. Recombinant Human Antithrombin in Pregnant Patients with Hereditary Antithrombin Deficiency: Integrated Analysis of Clinical Data. American Journal Of Perinatology 2015, 33: 343-349. PMID: 26461927, DOI: 10.1055/s-0035-1564423.Peer-Reviewed Original ResearchConceptsRecombinant human antithrombinVenous thromboembolismPregnant patientsDoses of anticoagulationHigh VTE riskPostpartum venous thromboembolismHereditary antithrombin deficiencyHuman antithrombinOnset of laborAnticoagulation therapyVTE eventsVTE riskCesarean deliveryTherapy durationProphylactic dosesWeight heparinPeripartum periodClinical trialsClinical dataAntithrombin deficiencyPatientsBody weightIU/TherapyDosesFolic acid supplementation in early pregnancy and the risk of preeclampsia, small for gestational age offspring and preterm delivery
Martinussen MP, Bracken MB, Triche EW, Jacobsen GW, Risnes KR. Folic acid supplementation in early pregnancy and the risk of preeclampsia, small for gestational age offspring and preterm delivery. European Journal Of Obstetrics & Gynecology And Reproductive Biology 2015, 195: 94-99. PMID: 26500184, PMCID: PMC4684439, DOI: 10.1016/j.ejogrb.2015.09.022.Peer-Reviewed Original ResearchMeSH KeywordsAdultCohort StudiesFemaleFolic AcidHumansInfant, Low Birth WeightInfant, NewbornInfant, Small for Gestational AgeObesityOdds RatioPre-EclampsiaPregnancyPregnancy ComplicationsPregnancy Trimester, FirstPremature BirthProspective StudiesProtective FactorsRisk FactorsVitamin B ComplexYoung AdultConceptsFolic acid supplementationLow birth weightFolic acid intakePreterm birthAcid supplementationFirst trimesterLean mothersBirth weightAcid intakeEarly pregnancyOdds ratioGestational age offspringProspective cohort studyFolic acid supplementsFolic acid usePregnancy outcome dataRisk of preeclampsiaPossible protective effectMonths of pregnancyObese mothersPreterm deliveryCohort studyObstetric recordsAge offspringFolate intakeThe effect of labour induction on the risk of caesarean delivery: using propensity scores to control confounding by indication
Danilack V, Dore D, Triche E, Muri J, Phipps M, Savitz D. The effect of labour induction on the risk of caesarean delivery: using propensity scores to control confounding by indication. BJOG An International Journal Of Obstetrics & Gynaecology 2015, 123: 1521-1529. PMID: 26411752, DOI: 10.1111/1471-0528.13682.Peer-Reviewed Original ResearchConceptsWeeks of gestationCaesarean deliveryLabor inductionRisk ratioPropensity scoreElevated riskNational Perinatal Information CenterPrimary caesarean deliveryRisk of caesareanAdministrative hospital discharge dataHospital discharge dataMedical record informationCross-sectional analysisExpectant managementPreterm deliveryLiveborn deliveryPropensity score methodsGestationMember hospitalsPS adjustmentWeeksCovariate adjustmentSubsequent weeksTraditional covariatesRiskPre-Pregnancy BMI, Gestational Weight Gain, and the Risk of Hypertensive Disorders of Pregnancy: A Cohort Study in Wuhan, China
Zhou A, Xiong C, Hu R, Zhang Y, Bassig BA, Triche E, Yang S, Qiu L, Zhang Y, Yao C, Xu S, Wang Y, Xia W, Qian Z, Zheng T, Zhang B. Pre-Pregnancy BMI, Gestational Weight Gain, and the Risk of Hypertensive Disorders of Pregnancy: A Cohort Study in Wuhan, China. PLOS ONE 2015, 10: e0136291. PMID: 26305565, PMCID: PMC4548954, DOI: 10.1371/journal.pone.0136291.Peer-Reviewed Original ResearchConceptsTotal gestational weight gainGestational weight gainRisk of HDPPre-pregnancy BMIRisk factorsHypertensive disordersCohort studyBMI gainEarly gestational weight gainMaternal pre-pregnancy BMIChinese womenWeight gainMultiple unconditional logistic regressionLive singleton pregnancyUnconditional logistic regressionNormal-weight counterpartsPutative risk factorsWeight control effortsSingleton pregnanciesMaternal deathsEarly pregnancyIOM recommendationsMedicine recommendationsElevated riskPregnancyGenetic Risk Score for Essential Hypertension and Risk of Preeclampsia
Smith CJ, Saftlas AF, Spracklen CN, Triche EW, Bjonnes A, Keating B, Saxena R, Breheny PJ, Dewan AT, Robinson JG, Hoh J, Ryckman KK. Genetic Risk Score for Essential Hypertension and Risk of Preeclampsia. American Journal Of Hypertension 2015, 29: 17-24. PMID: 26002928, PMCID: PMC4692983, DOI: 10.1093/ajh/hpv069.Peer-Reviewed Original ResearchConceptsDiastolic blood pressureSystolic blood pressureGenetic risk scoreRisk of preeclampsiaBlood pressureEssential hypertensionRisk scoreNormotensive pregnant controlsHypertensive complicationsArterial pressurePregnant controlsWeeks' gestationPreeclamptic casesHypertensive stateEpidemiological evidenceHypertensionPreeclampsiaUS populationNonsignificant associationGenetic risk lociGenetic susceptibilitySwab samplesBuccal swab samplesGenetic riskRegression analysisGestational weight gain among American Samoan women and its impact on delivery and infant outcomes
Hawley NL, Johnson W, Hart CN, Triche EW, Ah Ching J, Muasau-Howard B, McGarvey ST. Gestational weight gain among American Samoan women and its impact on delivery and infant outcomes. BMC Pregnancy And Childbirth 2015, 15: 10. PMID: 25643752, PMCID: PMC4324802, DOI: 10.1186/s12884-015-0451-1.Peer-Reviewed Original ResearchConceptsGestational weight gainEarly pregnancy weightTrimester weight gainThird trimester weight gainAmerican Samoan womenPregnancy weightWeight gainInfant outcomesSamoan womenSecond trimester weight gainExcess gestational weight gainExcessive gestational weight gainAppropriate gestational weight gainGreater gestational weight gainMedicine GWG guidelinesPrenatal care recordsOverweight/obeseOverweight/obesityExcess weight gainLevels of obesityOutcomes of interestBinary logistic regressionAdverse pregnancyInfant overweightLGA infants
2014
Genetic Predisposition to Dyslipidemia and Risk of Preeclampsia
Spracklen CN, Saftlas AF, Triche EW, Bjonnes A, Keating B, Saxena R, Breheny PJ, Dewan AT, Robinson JG, Hoh J, Ryckman KK. Genetic Predisposition to Dyslipidemia and Risk of Preeclampsia. American Journal Of Hypertension 2014, 28: 915-923. PMID: 25523295, PMCID: PMC4542907, DOI: 10.1093/ajh/hpu242.Peer-Reviewed Original ResearchMeSH KeywordsAdultBiomarkersBlood PressureCase-Control StudiesChi-Square DistributionCholesterol, HDLCholesterol, LDLDyslipidemiasFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansIowaLogistic ModelsMultivariate AnalysisOdds RatioPhenotypePolymorphism, Single NucleotidePre-EclampsiaPregnancyRisk FactorsTriglyceridesYoung AdultLow-to-moderate prenatal alcohol consumption and the risk of selected birth outcomes: a prospective cohort study
Lundsberg LS, Illuzzi JL, Belanger K, Triche EW, Bracken MB. Low-to-moderate prenatal alcohol consumption and the risk of selected birth outcomes: a prospective cohort study. Annals Of Epidemiology 2014, 25: 46-54.e3. PMID: 25453352, PMCID: PMC4255148, DOI: 10.1016/j.annepidem.2014.10.011.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcohol DrinkingConfidence IntervalsConfounding Factors, EpidemiologicConnecticutFemaleFetal Growth RetardationGestational AgeHumansInfant, Low Birth WeightInfant, NewbornLogistic ModelsMassachusettsMaternal-Fetal ExchangeOdds RatioPregnancyPregnancy ComplicationsPregnancy OutcomePremature BirthProspective StudiesRisk FactorsConceptsIntrauterine growth restrictionLow birthweightPreterm deliveryBirth lengthBirth outcomesGrowth restrictionAlcohol exposureOdds ratioLower oddsModerate prenatal alcohol exposureModerate alcohol exposureThird-trimester drinkingProspective cohort studyMultivariable logistic regressionConfidence intervalsPrenatal alcohol consumptionPrenatal alcohol exposurePregnancy drinkingNeonatal outcomesPerinatal outcomesSingleton infantsCohort studyAlcohol drinkingReduced oddsHead circumferenceBioinformatic Approach to the Genetics of Preeclampsia
Triche EW, Uzun A, DeWan AT, Kurihara I, Liu J, Occhiogrosso R, Shen B, Parker J, Padbury JF. Bioinformatic Approach to the Genetics of Preeclampsia. Obstetrics And Gynecology 2014, 123: 1155-1161. PMID: 24807322, PMCID: PMC4409136, DOI: 10.1097/aog.0000000000000293.Peer-Reviewed Original Research
2013
The Relationship Between Parental Stress and Postpartum Depression Among Adolescent Mothers Enrolled in a Randomized Controlled Prevention Trial
Venkatesh K, Phipps M, Triche E, Zlotnick C. The Relationship Between Parental Stress and Postpartum Depression Among Adolescent Mothers Enrolled in a Randomized Controlled Prevention Trial. Maternal And Child Health Journal 2013, 18: 1532-1539. PMID: 24281848, PMCID: PMC4603360, DOI: 10.1007/s10995-013-1394-7.Peer-Reviewed Original ResearchConceptsAdjusted odds ratioDepression Rating ScalePostpartum depressionPrimiparous adolescent mothersSubthreshold depressionAdolescent mothersMonths postpartumRisk factorsParental stressDSM-IV Childhood DiagnosesSubsequent postpartum depressionChildren's Depression Rating ScaleSignificant risk factorsStructured Clinical InterviewPostpartum visitMedian agePrevention trialsStudy armsParenting Stress IndexOdds ratioStudy visitDepression diagnosisPrior historyDepression severityClinical InterviewCumulative exposure to paternal seminal fluid prior to conception and subsequent risk of preeclampsia
Saftlas A, Rubenstein L, Prater K, Harland K, Field E, Triche E. Cumulative exposure to paternal seminal fluid prior to conception and subsequent risk of preeclampsia. Journal Of Reproductive Immunology 2013, 101: 104-110. PMID: 24011785, DOI: 10.1016/j.jri.2013.07.006.Peer-Reviewed Original ResearchConceptsRisk of preeclampsiaVaginal exposureNulliparous womenImmune maladaptation hypothesisOdds of preeclampsiaMedical chart reviewPercentile of exposureBarrier contraceptive methodsCase-control studyVaginal sexual intercourseAllogeneic fetusChart reviewIowa womenPaternal HLAAntigen exposureImmune toleranceNormotensive controlsPaternal antigensMaternal tolerancePreeclampsia casesPreeclampsia riskSubsequent riskSeminal fluidLive birthsContraceptive useMaternal–fetal HLA sharing and preeclampsia: variation in effects by seminal fluid exposure in a case–control study of nulliparous women in Iowa
Triche E, Harland K, Field E, Rubenstein L, Saftlas A. Maternal–fetal HLA sharing and preeclampsia: variation in effects by seminal fluid exposure in a case–control study of nulliparous women in Iowa. Journal Of Reproductive Immunology 2013, 101: 111-119. PMID: 23998333, PMCID: PMC4060772, DOI: 10.1016/j.jri.2013.06.004.Peer-Reviewed Original ResearchConceptsCase-control studyHLA sharingSemen exposureNulliparous womenClass IHLA typingComplete HLA typingMaternal-fetal histocompatibilityOdds of preeclampsiaMother-baby pairsHLA-A matchingVaginal exposureNormotensive controlsSuccessful pregnancyPreeclampsia casesContraceptive usePreeclampsiaEligibility criteriaFluid exposureIngestion practicesClass IIMultivariate modelStudy sampleExposure historyType of practice