2020
Prospective, randomized, double-blind, placebo-controlled evaluation of the Pharmacokinetics, Safety and Efficacy of Recombinant Antithrombin Versus Placebo in Preterm Preeclampsia
Paidas MJ, Tita ATN, Macones GA, Saade GA, Ehrenkranz RA, Triche EW, Streisand JB, Lam GK, Magann EF, Lewis DF, Dombrowski MP, Werner EF, Branch DW, Habli MA, Grotegut CA, Silver RM, Longo SA, Amon E, Cleary K, How HY, Novotny SR, Grobman WA, Whiteman VE, Wing DA, Scifres CM, Sibai BM. Prospective, randomized, double-blind, placebo-controlled evaluation of the Pharmacokinetics, Safety and Efficacy of Recombinant Antithrombin Versus Placebo in Preterm Preeclampsia. American Journal Of Obstetrics And Gynecology 2020, 223: 739.e1-739.e13. PMID: 32780999, DOI: 10.1016/j.ajog.2020.08.004.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, IntravenousAdolescentAdultAntithrombin ProteinsCesarean SectionDelivery, ObstetricDouble-Blind MethodFemaleFetal DistressGestational AgeHumansInfant, Premature, DiseasesInfant, Small for Gestational AgeMiddle AgedNeonatal SepsisPerinatal MortalityPre-EclampsiaPregnancyPregnancy Trimester, SecondPregnancy Trimester, ThirdProspective StudiesRecombinant ProteinsYoung AdultConceptsRecombinant human antithrombinPreterm preeclampsiaExpectant managementMorbidity scoreHuman antithrombinPlacebo-controlled clinical trialPlacebo-controlled evaluationPlacebo-controlled trialMedian gestational ageMaternal complicationsVersus PlaceboFetal outcomesMaternal outcomesPreterm deliveryEndothelial dysfunctionSecondary outcomesSingleton pregnanciesStandard therapyLoading dosePrimary outcomeWeeks' gestationGestational ageContinuous infusionClinical trialsSaline infusion
2017
The Effect of Labour Induction on the Risk of Caesarean Delivery
Danilack V, Dore D, Triche E, Muri J, Phipps M, Savitz D. The Effect of Labour Induction on the Risk of Caesarean Delivery. Obstetric Anesthesia Digest 2017, 37: 83. DOI: 10.1097/01.aoa.0000515754.91071.a0.Peer-Reviewed Original ResearchRisk of CDLabor inductionCesarean deliveryIntrauterine growth restrictionCaesarean deliveryExpectant managementPostterm pregnancyUnderwent inductionGrowth restrictionPropensity score methodsMedical reasonsPropensity scoreEffect estimatesPreeclampsiaRiskInductionPresent studyAssociationScore methodPotential benefitsIndicationsDeliveryOligohydramniosPregnancyFetuses
2016
Comparing expectant management and spontaneous labor approaches in studying the effect of labor induction on cesarean delivery
Danilack VA, Triche EW, Dore DD, Muri JH, Phipps MG, Savitz DA. Comparing expectant management and spontaneous labor approaches in studying the effect of labor induction on cesarean delivery. Annals Of Epidemiology 2016, 26: 405-411.e1. PMID: 27211604, DOI: 10.1016/j.annepidem.2016.04.009.Peer-Reviewed Original ResearchConceptsCesarean deliveryLabor inductionExpectant managementRisk ratioWeek 34Week 37Comparison groupRisk of CDIntrauterine growth restrictionMother-newborn dyadsSpontaneous laborVaginal deliveryWeeks' gestationWeek 36Maternal ageSpontaneous onsetGrowth restrictionDiabetic disordersWeek 40High riskLower riskClinical practiceWeek 41Member hospitalsGestation
2015
The effect of labour induction on the risk of caesarean delivery: using propensity scores to control confounding by indication
Danilack V, Dore D, Triche E, Muri J, Phipps M, Savitz D. The effect of labour induction on the risk of caesarean delivery: using propensity scores to control confounding by indication. BJOG An International Journal Of Obstetrics & Gynaecology 2015, 123: 1521-1529. PMID: 26411752, DOI: 10.1111/1471-0528.13682.Peer-Reviewed Original ResearchConceptsWeeks of gestationCaesarean deliveryLabor inductionRisk ratioPropensity scoreElevated riskNational Perinatal Information CenterPrimary caesarean deliveryRisk of caesareanAdministrative hospital discharge dataHospital discharge dataMedical record informationCross-sectional analysisExpectant managementPreterm deliveryLiveborn deliveryPropensity score methodsGestationMember hospitalsPS adjustmentWeeksCovariate adjustmentSubsequent weeksTraditional covariatesRisk
2013
Exploring the Role of Antithrombin Replacement for the Treatment of Preeclampsia: A Prospective Randomized Evaluation of the Safety and Efficacy of Recombinant Antithrombin in Very Preterm Preeclampsia (PRESERVE‐1)
Paidas MJ, Sibai BM, Triche EW, Frieling J, Lowry S, Group T. Exploring the Role of Antithrombin Replacement for the Treatment of Preeclampsia: A Prospective Randomized Evaluation of the Safety and Efficacy of Recombinant Antithrombin in Very Preterm Preeclampsia (PRESERVE‐1). American Journal Of Reproductive Immunology 2013, 69: 539-544. PMID: 23444920, DOI: 10.1111/aji.12091.Peer-Reviewed Original ResearchConceptsProspective Randomized EvaluationAntithrombin replacementWeeks' gestationRandomized EvaluationRecombinant antithrombinTreatment of preeclampsiaRecombinant human ATExpectant managementPreterm preeclampsiaPrimary endpointMaternal indicationsGestational ageStudy enrollmentAT therapyPreeclampsia studyPreeclampsiaGestationHuman ATAT replacementPharmacokinetic activityAntithrombinEfficacySafetyLaboratory assaysDelivery