2024
The Impact of Active Ascertainment on Sex-Specific Differences in the Prevalence and Phenotype of Transthyretin Cardiac Amyloidosis: The SCAN-MP Study
Chan N, Einstein A, Teruya S, Rodriguez C, Helmke S, Cuomo M, Santana D, Castillo M, Smiley D, Sabogal N, Lamour S, Winburn M, Fine D, de Freitas C, Kattan C, Miller E, Maurer M, Ruberg F. The Impact of Active Ascertainment on Sex-Specific Differences in the Prevalence and Phenotype of Transthyretin Cardiac Amyloidosis: The SCAN-MP Study. The American Journal Of Cardiology 2024 PMID: 39581521, DOI: 10.1016/j.amjcard.2024.11.019.Peer-Reviewed Original ResearchATTR-CATransthyretin cardiac amyloidosisProportion of womenCardiac amyloidosisReferral cohortLower left ventricular mass indexHigher left ventricular ejection fractionPrevalence of ATTR-CAATTR-CA patientsWild-type diseaseVentricular ejection fractionVentricular mass indexPosterior wall thicknessAscertainment cohortLeft ventricular hypertrophyReduce sex disparitiesHigher proportion of womenATTRwt-CAEjection fractionEchocardiographic evidenceHeart failureMass indexSex-specific differencesSevere phenotypeSex distribution
2012
The Polyphenols Resveratrol and S17834 Prevent the Structural and Functional Sequelae of Diet-Induced Metabolic Heart Disease in Mice
Qin F, Siwik DA, Luptak I, Hou X, Wang L, Higuchi A, Weisbrod RM, Ouchi N, Tu VH, Calamaras TD, Miller EJ, Verbeuren TJ, Walsh K, Cohen RA, Colucci WS. The Polyphenols Resveratrol and S17834 Prevent the Structural and Functional Sequelae of Diet-Induced Metabolic Heart Disease in Mice. Circulation 2012, 125: 1757-1764. PMID: 22388319, PMCID: PMC3354628, DOI: 10.1161/circulationaha.111.067801.Peer-Reviewed Original ResearchConceptsHFHS diet-fed miceDiet-fed miceMetabolic heart diseaseDiastolic dysfunctionLeft ventricular hypertrophyMyocardial oxidative stressVentricular hypertrophyHeart diseaseInterstitial fibrosisPlasma adiponectinInsulin resistanceProgressive left ventricular hypertrophyDiet-induced metabolic syndromeBeneficial effectsOxidative stressHomeostasis model assessmentMale C57BL/6J miceChronic hemodynamic overloadHFHS dietCardiovascular effectsSystolic functionDiabetes mellitusMetabolic syndromeConcomitant treatmentHemodynamic overload