2021
Genetic variation in endocannabinoid signaling is associated with differential network‐level functional connectivity in youth
Sisk LM, Rapuano KM, Conley MI, Greene AS, Horien C, Rosenberg MD, Scheinost D, Constable RT, Glatt CE, Casey BJ, Gee DG. Genetic variation in endocannabinoid signaling is associated with differential network‐level functional connectivity in youth. Journal Of Neuroscience Research 2021, 100: 731-743. PMID: 34496065, PMCID: PMC8866205, DOI: 10.1002/jnr.24946.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAmygdalaAnxietyAnxiety DisordersEndocannabinoidsFemaleHumansMagnetic Resonance ImagingMalePolymorphism, Single NucleotideConceptsEndocannabinoid signalingAllele carriersLower anxiety symptomsC385A polymorphismNetwork-level functional connectivityEnhanced endocannabinoid signalingLarge-scale resting-state brain networksAnxiety symptomsResting-state brain networksGenotype-associated differencesBrain networksFronto-amygdala connectivityFunctional connectionsCognitive Development StudyNetwork-level changesPotential protective factorsAdolescent Brain Cognitive Development (ABCD) studyEndocannabinoid systemNetwork-level differencesYounger ageFunctional connectivityProtective factorsNeural phenotypesAnxiety disordersNeural connectivity
2017
The Role of the Endocannabinoid System and Genetic Variation in Adolescent Brain Development
Meyer HC, Lee FS, Gee DG. The Role of the Endocannabinoid System and Genetic Variation in Adolescent Brain Development. Neuropsychopharmacology 2017, 43: 21-33. PMID: 28685756, PMCID: PMC5719094, DOI: 10.1038/npp.2017.143.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdolescent DevelopmentAnimalsBrainEmotionsEndocannabinoidsGenetic VariationHumansSexual MaturationConceptsAnxiety-related behaviorDevelopmental trajectoriesAdolescent brain developmentRegulation of fearConsequences of stressGenetic variationBrain developmentBehavioral processingECB systemPrefrontal cortexEmotional behaviorHuman genetic variationCorticolimbic structuresStress responsivityBrain regionsAdolescenceRegulation of stressNeural circuitsEndocannabinoid systemAnxietyEnvironmental perturbationsRole of eCBFunctional implicationsCentral roleLife span
2016
Individual differences in frontolimbic circuitry and anxiety emerge with adolescent changes in endocannabinoid signaling across species
Gee DG, Fetcho RN, Jing D, Li A, Glatt CE, Drysdale AT, Cohen AO, Dellarco DV, Yang RR, Dale AM, Jernigan TL, Lee FS, Casey BJ, Jernigan T, San Diego U, McCabe C, San Diego U, Chang L, Hawaii U, Akshoomoff N, San Diego U, Newman E, San Diego U, Dale A, San Diego U, Core M, Ernst T, Hawaii U, Dale A, San Diego U, Van Zijl P, Kuperman J, San Diego U, Murray S, Bloss C, Schork N, Appelbaum M, San Diego U, Gamst A, San Diego U, Thompson W, San Diego U, Bartsch H, San Diego U, Jernigan T, Dale A, Akshoomoff N, Chang L, Ernst T, Keating B, Amaral D, Sowell E, Kaufmann W, Van Zijl P, Mostofsky S, Casey B, Ruberry E, Powers A, Rosen B, Kenet T, Frazier J, Kennedy D, University Y, Gruen J. Individual differences in frontolimbic circuitry and anxiety emerge with adolescent changes in endocannabinoid signaling across species. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: 4500-4505. PMID: 27001846, PMCID: PMC4843434, DOI: 10.1073/pnas.1600013113.Peer-Reviewed Original ResearchConceptsFatty acid amide hydrolaseAnxiety-related behaviorGene expressionFrontolimbic circuitryEndocannabinoid signalingAnxiety disordersNeural circuit maturationPostnatal day 45Phenotypic differencesFrontoamygdala circuitryAnandamide levelsGenetic effectsAEA levelsBiological stateIndividual differencesCircuit maturationGenetic alterationsFAAH genotypeMouse modelDevelopmental neurobiologyLevels of analysisAdolescent changesDevelopmental windowAmide hydrolaseBrain circuitry