2024
Responding to threat: Associations between neural reactivity to and behavioral avoidance of threat in pediatric anxiety
Kitt E, Zacharek S, Odriozola P, Nardini C, Hommel G, Martino A, Anderson T, Spencer H, Broussard A, Dean J, Marin C, Silverman W, Lebowitz E, Gee D. Responding to threat: Associations between neural reactivity to and behavioral avoidance of threat in pediatric anxiety. Journal Of Affective Disorders 2024, 351: 818-826. PMID: 38290579, PMCID: PMC10981528, DOI: 10.1016/j.jad.2024.01.204.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAmygdalaAnxietyAnxiety DisordersBrain MappingChildHumansMagnetic Resonance ImagingPrefrontal CortexConceptsReactivity to threatMeasures of avoidanceVentral anterior insulaClinician-based measuresNeural reactivityPediatric anxietyAnxiety disordersBehavioral avoidanceFunctional magnetic resonance imaging taskAmygdala functional connectivityVentromedial prefrontal cortexTreatment-seeking sampleAvoidance of threatClinically significant constructsAssociated with tasksGeneralizability of findingsPrefrontal cortexAnterior insulaNeural findingsLaboratory tasksFunctional connectivityAnxietyAmygdalaAvoidanceSignificant constructs
2022
Experimental evidence for a child‐to‐adolescent switch in human amygdala‐prefrontal cortex communication: A cross‐sectional pilot study
Gee DG, Hanson C, Caglar LR, Fareri DS, Gabard‐Durnam L, Mills‐Finnerty C, Goff B, Caldera CJ, Lumian DS, Flannery J, Hanson SJ, Tottenham N. Experimental evidence for a child‐to‐adolescent switch in human amygdala‐prefrontal cortex communication: A cross‐sectional pilot study. Developmental Science 2022, 25: e13238. PMID: 35080089, PMCID: PMC9232876, DOI: 10.1111/desc.13238.Peer-Reviewed Original ResearchConceptsCross-sectional pilot studyAge-related switchAmygdala reactivityPresent cross-sectional pilot studyPilot studyAnterior cingulate cortex activationDorsal anterior cingulate cortex (dACC) activationAmygdala connectivityCortex activationPrefrontal cortexDACC activationAmygdalaPrefrontal functionChildhoodPrefrontal engagementEmotional behaviorChildhood experiencesAdolescenceVentromedial PFCDACCOpposite effectBayesian network analysisActivationVmPFCReverse information flow
2020
Learning About Safety: Conditioned Inhibition as a Novel Approach to Fear Reduction Targeting the Developing Brain
Odriozola P, Gee DG. Learning About Safety: Conditioned Inhibition as a Novel Approach to Fear Reduction Targeting the Developing Brain. American Journal Of Psychiatry 2020, 178: 136-155. PMID: 33167673, PMCID: PMC7951569, DOI: 10.1176/appi.ajp.2020.20020232.Peer-Reviewed Original ResearchConceptsSafety signal learningExtinction learningSignal learningAnxiety disordersAnxious youthSafety cuesDorsal anterior cingulate cortexInhibition of fearFronto-amygdala circuitryCross-species evidenceAnterior cingulate cortexFear responsesAnxiety-like behaviorFrontolimbic circuitryCingulate cortexNeural circuitryCore featuresPrelimbic cortexBasic neuroscienceTranslational frameworkCuesYouthFearLearningAnimal modelsComparing neural correlates of conditioned inhibition between children with and without anxiety disorders – A preliminary study
Harrewijn A, Kitt ER, Abend R, Matsumoto C, Odriozola P, Winkler AM, Leibenluft E, Pine DS, Gee DG. Comparing neural correlates of conditioned inhibition between children with and without anxiety disorders – A preliminary study. Behavioural Brain Research 2020, 399: 112994. PMID: 33160010, PMCID: PMC7855938, DOI: 10.1016/j.bbr.2020.112994.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyPediatric anxiety disordersAnxiety disordersNeural correlatesHigher skin conductance responsesDorsal anterior cingulate cortexRight ventromedial prefrontal cortexVentromedial prefrontal cortexSkin conductance responsesReduced fear responsesAnterior cingulate cortexCurrent pilot studyThreat learningAnxious youthSafety cuesThreat cuesFear acquisitionVmPFC activityAversive soundSafety compoundCBT responseFear responsesNovel cuesConductance responsesPrefrontal cortex
2017
Development of the emotional brain
Casey BJ, Heller AS, Gee DG, Cohen AO. Development of the emotional brain. Neuroscience Letters 2017, 693: 29-34. PMID: 29197573, PMCID: PMC5984129, DOI: 10.1016/j.neulet.2017.11.055.Peer-Reviewed Original ResearchConceptsEmotion reactivityEmotional brainCognitive control circuitryNeurobiological accountsEmotional developmentRecent imaging studiesSelf-RegulationSocial situationsNeural circuitryYoung adulthoodAdolescenceImaging studiesHierarchical changesCircuitryDynamic reorganizationSubcorticoBrainCascade of changesAdulthoodLimbicControl circuitrySituationInstantiationDevelopment
2016
Stimulus-Elicited Connectivity Influences Resting-State Connectivity Years Later in Human Development: A Prospective Study
Gabard-Durnam LJ, Gee DG, Goff B, Flannery J, Telzer E, Humphreys KL, Lumian DS, Fareri DS, Caldera C, Tottenham N. Stimulus-Elicited Connectivity Influences Resting-State Connectivity Years Later in Human Development: A Prospective Study. Journal Of Neuroscience 2016, 36: 4771-4784. PMID: 27122035, PMCID: PMC4846673, DOI: 10.1523/jneurosci.0598-16.2016.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexFunctional connectivityAmygdala-medial prefrontal cortex circuitInferior frontal gyrusResting-state functional networksFunctional architectureResting-state connectivityAmygdala functional connectivityFunctional network architecturePrefrontal cortex circuitAmygdala-mPFC circuitResting-state networksFunctional connectionsEmotional stimuliCourse of developmentFrontal gyrusAge-related changesPrefrontal cortexMotivate future investigationsCortex circuitPredictive associationsSensitive periodFunctional networksDevelopmental periodBrain function
2014
Maternal Buffering of Human Amygdala-Prefrontal Circuitry During Childhood but Not During Adolescence
Gee DG, Gabard-Durnam L, Telzer EH, Humphreys KL, Goff B, Shapiro M, Flannery J, Lumian DS, Fareri DS, Caldera C, Tottenham N. Maternal Buffering of Human Amygdala-Prefrontal Circuitry During Childhood but Not During Adolescence. Psychological Science 2014, 25: 2067-2078. PMID: 25280904, PMCID: PMC4377225, DOI: 10.1177/0956797614550878.Peer-Reviewed Original ResearchConceptsAmygdala-prefrontal circuitryMaternal bufferingMaternal stimuliAmygdala-prefrontal connectivityMature connectivityAmygdala reactivityPotential mechanismsMaternal modulationChildhoodMother-child relationshipNeural mechanismsSensitive periodChildrenCaregiversMaternal influenceRegulatory influenceAdolescenceStimuliBehavioral regulationNeurocircuitryCircuitry
2013
A Developmental Shift from Positive to Negative Connectivity in Human Amygdala–Prefrontal Circuitry
Gee DG, Humphreys KL, Flannery J, Goff B, Telzer EH, Shapiro M, Hare TA, Bookheimer SY, Tottenham N. A Developmental Shift from Positive to Negative Connectivity in Human Amygdala–Prefrontal Circuitry. Journal Of Neuroscience 2013, 33: 4584-4593. PMID: 23467374, PMCID: PMC3670947, DOI: 10.1523/jneurosci.3446-12.2013.Peer-Reviewed Original ResearchConceptsAmygdala-prefrontal circuitryFunctional connectivityNegative connectivityAmygdala reactivityRecent human imagingParticipants 10 yearsTask-based functional magnetic resonance imagingNegative functional connectivityFunctional magnetic resonance imagingMagnetic resonance imagingAmygdala-prefrontal connectivityAmygdala-cortical connectivityAnxiety-related disordersFrontoamygdala circuitryAnimal studiesReciprocal connectionsResonance imagingTracing studyPositive connectivityAdolescent periodEarly childhoodNeurobiological basisEmotional behaviorPresent studyDevelopmental changes
2010
Low frequency fluctuations reveal integrated and segregated processing among the cerebral hemispheres
Gee DG, Biswal BB, Kelly C, Stark DE, Margulies DS, Shehzad Z, Uddin LQ, Klein DF, Banich MT, Castellanos FX, Milham MP. Low frequency fluctuations reveal integrated and segregated processing among the cerebral hemispheres. NeuroImage 2010, 54: 517-527. PMID: 20570737, PMCID: PMC3134281, DOI: 10.1016/j.neuroimage.2010.05.073.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityFunctional magnetic resonance imagingFunctional connectivityResting-state functional magnetic resonance imagingInterhemispheric interactionsResting-state fMRI scansSpontaneous low-frequency fluctuationsLow-frequency fluctuationsInterhemispheric processingMagnetic resonance imagingRSFC strengthCerebral hemispheresHomotopic regionsIntrahemispheric processingResonance imagingNegative connectivityEntire cerebrumConnectivity strengthFMRI scansHealthy participantsBOLD signalSegregated processingPresent studyOpposite hemisphereHemisphere