2014
Borrelia miyamotoi sensu lato Seroreactivity and Seroprevalence in the Northeastern United States - Volume 20, Number 7—July 2014 - Emerging Infectious Diseases journal - CDC
Krause PJ, Narasimhan S, Wormser GP, Barbour AG, Platonov AE, Brancato J, Lepore T, Dardick K, Mamula M, Rollend L, Steeves TK, Diuk-Wasser M, Usmani-Brown S, Williamson P, Sarksyan DS, Fikrig E, Fish D, . Borrelia miyamotoi sensu lato Seroreactivity and Seroprevalence in the Northeastern United States - Volume 20, Number 7—July 2014 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2014, 20: 1183-1190. PMID: 24960072, PMCID: PMC4073859, DOI: 10.3201/eid2007.131587.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, BacterialBorreliaBorrelia InfectionsFemaleHumansImmunoglobulin GLyme DiseaseMaleMiddle AgedNew EnglandSeroepidemiologic StudiesConceptsB. burgdorferiInfectious Diseases journal - CDCSeroprevalence of IgGB. burgdorferi antigensLyme disease endemic areaDisease-endemic areasAntibody testingHealthy personsLyme diseaseSerum samplesSeroprevalenceBurgdorferiInfectionSame tickUnited StatesSensu latoArea residentsPersonsBorrelia spSeroreactivityIgGAntigenDiseaseSerum
2013
Human Borrelia miyamotoi Infection in the United States
Krause PJ, Narasimhan S, Wormser GP, Rollend L, Fikrig E, Lepore T, Barbour A, Fish D. Human Borrelia miyamotoi Infection in the United States. New England Journal Of Medicine 2013, 368: 291-293. PMID: 23323920, PMCID: PMC3934646, DOI: 10.1056/nejmc1215469.Peer-Reviewed Original Research
2011
Humans Infected with Relapsing Fever Spirochete Borrelia miyamotoi, Russia - Volume 17, Number 10—October 2011 - Emerging Infectious Diseases journal - CDC
Platonov AE, Karan LS, Kolyasnikova NM, Makhneva NA, Toporkova MG, Maleev VV, Fish D, Krause PJ. Humans Infected with Relapsing Fever Spirochete Borrelia miyamotoi, Russia - Volume 17, Number 10—October 2011 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2011, 17: 1816-1823. PMID: 22000350, PMCID: PMC3310649, DOI: 10.3201/eid1710.101474.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Bacterial AgentsAntibodies, BacterialBorreliaDoxycyclineHumansImmunoglobulin MPhylogenyRecurrenceRelapsing FeverRNA, Ribosomal, 16SRussiaConceptsB. miyamotoi infectionMiyamotoi infectionInfectious Diseases journal - CDCBorrelia miyamotoiInfluenza-like illnessB. burgdorferi infectionFever spirochete Borrelia miyamotoiDisease-like symptomsFebrile illnessI. ricinus ticksErythema migransClinical manifestationsIxodid tick vectorsBurgdorferi infectionI. scapularis ticksIxodes persulcatus ticksInfectionRicinus ticksScapularis ticksB. burgdorferiB. gariniiFeverWidespread prevalenceIllnessMiyamotoi
2004
Borrelia burgdorferi Infection in a Natural Population of Peromyscus Leucopus Mice: A Longitudinal Study in an Area Where Lyme Borreliosis Is Highly Endemic
Bunikis J, Tsao J, Luke C, Luna M, Fish D, Barbour A. Borrelia burgdorferi Infection in a Natural Population of Peromyscus Leucopus Mice: A Longitudinal Study in an Area Where Lyme Borreliosis Is Highly Endemic. The Journal Of Infectious Diseases 2004, 189: 1515-1523. PMID: 15073690, DOI: 10.1086/382594.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, BacterialAntigens, BacterialBacterial Outer Membrane ProteinsBlotting, WesternBorrelia burgdorferiConnecticutDisease ReservoirsDNA, BacterialEndemic DiseasesFemaleImmunoenzyme TechniquesIncidenceIxodesLongitudinal StudiesLyme DiseasePeromyscusPolymerase Chain ReactionRodent DiseasesSeasonsSeroepidemiologic StudiesConceptsPeromyscus leucopus miceLeucopus miceTransmission seasonBorrelia burgdorferi infectionPolymerase chain reactionSurface protein CBurgdorferi infectionBlood samplesMice ageEnzyme immunoassayLyme borreliosisMiceSerum samplesProtein CDynamics of infectionBorrelia burgdorferiB. burgdorferiChain reactionLongitudinal studyEnzootic siteInfectionAntibodiesEntire populationBurgdorferiIxodes scapularis
2001
Infection of Mice with the Agent of Human Granulocytic Ehrlichiosis after Different Routes of Inoculation
Hodzic E, Feng S, Fish D, Leutenegger C, Freet K, Barthold S. Infection of Mice with the Agent of Human Granulocytic Ehrlichiosis after Different Routes of Inoculation. The Journal Of Infectious Diseases 2001, 183: 1781-1786. PMID: 11372031, DOI: 10.1086/320735.Peer-Reviewed Original ResearchConceptsBone marrow samplesReal-time polymerase chain reactionPolymerase chain reactionHuman granulocytic ehrlichiosisMarrow samplesDay 20Granulocytic ehrlichiosisInfection of miceRate of infectionKinetics of infectionLymph nodesGene targetsInfected miceC3H miceEarly disseminationVascular perfusionDay 10Experimental infectionInfectionMiceNeedle inoculationChain reactionBloodEhrlichiosisInoculationOspA Immunization Decreases Transmission of Borrelia burgdorferi Spirochetes from Infected Peromyscus leucopus Mice to Larval Ixodes scapularis Ticks
Tsao J, Barbour A, Luke C, Fikrig E, Fish D. OspA Immunization Decreases Transmission of Borrelia burgdorferi Spirochetes from Infected Peromyscus leucopus Mice to Larval Ixodes scapularis Ticks. Vector-Borne And Zoonotic Diseases 2001, 1: 65-74. PMID: 12653137, DOI: 10.1089/153036601750137705.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, WildAntibodies, BacterialAntigens, SurfaceArachnid VectorsBacterial Outer Membrane ProteinsBacterial VaccinesBorrelia burgdorferiDisease ReservoirsDose-Response Relationship, ImmunologicEnzyme-Linked Immunosorbent AssayFluorescent Antibody Technique, DirectHost-Parasite InteractionsIxodesLarvaLipoproteinsLyme DiseasePeromyscusConceptsControl miceUninfected larval ticksInfection prevalenceLarval Ixodes scapularis ticksB. burgdorferiNumber of spirochetesEnzyme-linked immunosorbentBorrelia burgdorferi spirochetesLevel of immunizationReservoir hostsConcentration of antibodyBorrelia burgdorferi transmissionIxodes scapularis ticksSecond vaccinationImmunized miceInfected miceLarval ticksPrior infectionVaccination programSubsequent riskDecrease transmissionOspA vaccinationDirect immunofluorescenceImmune responseXenodiagnostic ticks
1998
Prevention of Borrelia burgdorferi transmission in guinea pigs by tick immunity.
Nazario S, Das S, de Silva AM, Deponte K, Marcantonio N, Anderson JF, Fish D, Fikrig E, Kantor FS. Prevention of Borrelia burgdorferi transmission in guinea pigs by tick immunity. American Journal Of Tropical Medicine And Hygiene 1998, 58: 780-5. PMID: 9660463, DOI: 10.4269/ajtmh.1998.58.780.Peer-Reviewed Original Research
1997
OspA antibodies inhibit the acquisition of Borrelia burgdorferi by Ixodes ticks
de Silva AM, Fish D, Burkot TR, Zhang Y, Fikrig E. OspA antibodies inhibit the acquisition of Borrelia burgdorferi by Ixodes ticks. Infection And Immunity 1997, 65: 3146-3150. PMID: 9234767, PMCID: PMC175444, DOI: 10.1128/iai.65.8.3146-3150.1997.Peer-Reviewed Original ResearchConceptsOspA antibodiesB. burgdorferiPassive antibody transferB. burgdorferi infectionIxodes ticksSurface protein ABurgdorferi-infected miceB. burgdorferi-infected miceLarval infection ratesOuter surface protein AAntibody transferAntibody responseBurgdorferi infectionInfection rateInfected ticksMiceInhibitory effectAntibodiesLarval infectionBorrelia burgdorferiBurgdorferiInfectionLarval ticksReservoir competenceSpirochetes
1996
Safety, efficacy, and immunogenicity of a recombinant Osp subunit canine Lyme disease vaccine
Ma J, Hine P, Clough E, Fish D, Coughlin R, Beltz G, Shew M. Safety, efficacy, and immunogenicity of a recombinant Osp subunit canine Lyme disease vaccine. Vaccine 1996, 14: 1366-1374. PMID: 9004447, DOI: 10.1016/s0264-410x(96)00045-x.Peer-Reviewed Original ResearchConceptsCanine Lyme disease vaccineLyme disease vaccineDisease vaccineGeometric mean antibody titersInjection site swellingMean antibody titersTypical clinical signsMonths postchallengeVaccination timeSecond vaccinationBorrelial antigensSpirochetal antigensAntibody titersProtective efficacyControl beaglesAdverse reactionsVaccinated dogsClinical signsImmunological memoryLocal reactionsAntibody productionNormal beaglesVaccinatesLyme diseaseOsp ASuppression of Acute Ixodes scapularis-Induced Borrelia burgdorferi Infection using Tumor Necrosis Factor-α, Interleukin-2, and Interferon-γ
Zeidner N, Dreitz M, Belasco D, Fish D. Suppression of Acute Ixodes scapularis-Induced Borrelia burgdorferi Infection using Tumor Necrosis Factor-α, Interleukin-2, and Interferon-γ. The Journal Of Infectious Diseases 1996, 173: 187-195. PMID: 8537658, DOI: 10.1093/infdis/173.1.187.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAnimalsAntibodies, BacterialArachnid VectorsBlotting, WesternBorrelia burgdorferi GroupDNA, BacterialDrug Therapy, CombinationElectrophoresis, Polyacrylamide GelFluorescent Antibody TechniqueImmune ToleranceImmunity, CellularInjections, IntraperitonealInterferon-gammaInterleukin-2IxodesLyme DiseaseMiceMice, Inbred C3HPolymerase Chain ReactionRandom AllocationTumor Necrosis Factor-alphaConceptsTumor necrosis factorNecrosis factorBurgdorferi infectionB. burgdorferiC3H/HeJ miceTick feedingBorrelia burgdorferi infectionB. burgdorferi infectionImmune containmentPolymerase chain reaction analysisCellular immunityCytokine productionIL-2TNF-alphaHeJ miceInterleukin-2IFN-gammaChain reaction analysisDay 21Infection rateWestern blotEar biopsiesProtection rateInfectionBorrelia burgdorferi
1995
Protection of Dogs from Lyme Disease with a Vaccine Containing Outer Surface Protein (Osp) A, OspB, and the Saponin Adjuvant QS21
Coughlin R, Fish D, Mather T, Ma J, Pavia C, Bulger P. Protection of Dogs from Lyme Disease with a Vaccine Containing Outer Surface Protein (Osp) A, OspB, and the Saponin Adjuvant QS21. The Journal Of Infectious Diseases 1995, 171: 1049-1052. PMID: 7706788, DOI: 10.1093/infdis/171.4.1049.Peer-Reviewed Original ResearchConceptsProtection of dogsAdjuvant QS21Vaccinated dogsControl dogsLyme diseaseIxodes scapularisOuter surface protein ABorrelia burgdorferi infectionB. burgdorferiSurface protein ADogsBurgdorferi infectionVaccineScapularisQS21InfectionDiseaseProtectionXenodiagnosisBurgdorferiProtein AFeverSymptomsLimp
1993
The distribution of canine exposure to Borrelia burgdorferi in a Lyme-Disease endemic area.
Falco R, Smith H, Fish D, Mojica B, Bellinger M, Harris H, Hechemy K. The distribution of canine exposure to Borrelia burgdorferi in a Lyme-Disease endemic area. American Journal Of Public Health 1993, 83: 1305-1310. PMID: 8363007, PMCID: PMC1694954, DOI: 10.2105/ajph.83.9.1305.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, BacterialBorrelia burgdorferi GroupDog DiseasesDogsLyme DiseaseNew YorkSeroepidemiologic StudiesConceptsCanine exposureEnzyme-linked immunosorbentLyme diseaseBorrelia burgdorferiLyme disease endemic areaIntensity of exposureHuman Lyme diseaseDistribution of exposureSeroprevalence ratesBlood samplesEndemic areasEquivocal samplesResident dogsWestchester CountyDiseaseMean numberCausative agentSignificant differencesExposureImmunosorbentDogsHuman riskBurgdorferiSimilar patternClose association
1986
SPIROCHETES IN TICKS AND ANTIBODIES TO BORRELIA BURGDORFERI IN WHITE-TAILED DEER FROM CONNECTICUT, NEW YORK STATE, AND NORTH CAROLINA
Magnarelli L, Anderson J, Apperson C, Fish D, Johnson R, Chappell W. SPIROCHETES IN TICKS AND ANTIBODIES TO BORRELIA BURGDORFERI IN WHITE-TAILED DEER FROM CONNECTICUT, NEW YORK STATE, AND NORTH CAROLINA. Journal Of Wildlife Diseases 1986, 22: 178-188. PMID: 3520030, DOI: 10.7589/0090-3558-22.2.178.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, BacterialBorreliaConnecticutDeerDogsFemaleFluorescent Antibody TechniqueMaleNew YorkNorth CarolinaSeasonsTicksConceptsB. burgdorferiIndirect immunofluorescence testIxodes damminiDirect fluorescent antibodyTick-infested areasSerologic evidenceLeptospira infectionImmunofluorescence testEtiologic agentLyme diseaseInfected ticksSerum samplesAntibodiesI. scapularisFluorescent antibodyRabbit antibodiesI. dammini nymphsBurgdorferiAdultsSpirochetesAmericanum adultsAmblyomma americanum adultsWhite-tailed deerIxodid ticksTicks