2017
Lyme disease ecology in a changing world: consensus, uncertainty and critical gaps for improving control
Kilpatrick AM, Dobson ADM, Levi T, Salkeld DJ, Swei A, Ginsberg HS, Kjemtrup A, Padgett KA, Jensen PM, Fish D, Ogden NH, Diuk-Wasser MA. Lyme disease ecology in a changing world: consensus, uncertainty and critical gaps for improving control. Philosophical Transactions Of The Royal Society B Biological Sciences 2017, 372: 20160117. PMID: 28438910, PMCID: PMC5413869, DOI: 10.1098/rstb.2016.0117.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBorrelia burgdorferiCommunicable Disease ControlHumansIncidenceIxodesLyme DiseaseRiskConceptsNorth AmericaLyme disease ecologyDeer abundanceDifferent habitatsVector-borne zoonotic diseaseTemperate regionsDisease ecologyLyme disease preventionHost speciesDisease riskTick abundanceKnowledge gapsTemporal variationReservoir competenceCommon tick-borne diseaseEcologySubstantial uncertaintyAbundanceHost communitiesTick-borne diseaseTick populationsCritical gapAmericaAreas of consensusDisease preventionClosely-related Borrelia burgdorferi (sensu stricto) strains exhibit similar fitness in single infections and asymmetric competition in multiple infections
Rynkiewicz EC, Brown J, Tufts DM, Huang CI, Kampen H, Bent SJ, Fish D, Diuk-Wasser MA. Closely-related Borrelia burgdorferi (sensu stricto) strains exhibit similar fitness in single infections and asymmetric competition in multiple infections. Parasites & Vectors 2017, 10: 64. PMID: 28166814, PMCID: PMC5292797, DOI: 10.1186/s13071-016-1964-9.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibiosisArachnid VectorsBorrelia burgdorferiDisease Transmission, InfectiousGenetic FitnessIxodesMicePeromyscusConceptsAsymmetric competitive interactionsPatterns of coexistenceBiotic contextCommon disease vectorPathogen communitiesVector-borne pathogensBorrelia burgdorferiLong-term persistencePathogen speciesAsymmetric competitionPathogen dynamicsInfection phenotypesSimilar fitnessTransmission phenotypeDisease vectorsTemperate regionsCompetitive interactionsTransmission advantagePathogen strainsPathogen persistenceBlack-legged tickCompetitive strainsPeromyscus leucopusWhite-footed miceHost
2015
Association between body size and reservoir competence of mammals bearing Borrelia burgdorferi at an endemic site in the northeastern United States
Barbour AG, Bunikis J, Fish D, Hanincová K. Association between body size and reservoir competence of mammals bearing Borrelia burgdorferi at an endemic site in the northeastern United States. Parasites & Vectors 2015, 8: 299. PMID: 26024881, PMCID: PMC4459683, DOI: 10.1186/s13071-015-0903-5.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBody SizeBorrelia burgdorferiDisease ReservoirsFemaleHumansIxodesLarvaLyme DiseaseMammalsNew EnglandNymphTick InfestationsConceptsBody sizeLarge-sized mammalsMedium-sized mammalsDifferent mammalian speciesEastern North AmericaSpecies-specific PCRLyme disease agentSmall mammalsMammalian speciesWhite-footed mouseCommon raccoonSized mammalsMammalsBorrelia burgdorferiPine volesBody massGrey squirrelsVirginia opossumReservoir competenceEastern chipmunksIxodes scapularis ticksDisease agentsStriped skunksSpeciesNymphal Ixodes scapularis ticks
2014
Borrelia burgdorferi Promotes the Establishment of Babesia microti in the Northeastern United States
Dunn JM, Krause PJ, Davis S, Vannier EG, Fitzpatrick MC, Rollend L, Belperron AA, States SL, Stacey A, Bockenstedt LK, Fish D, Diuk-Wasser MA. Borrelia burgdorferi Promotes the Establishment of Babesia microti in the Northeastern United States. PLOS ONE 2014, 9: e115494. PMID: 25545393, PMCID: PMC4278703, DOI: 10.1371/journal.pone.0115494.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBabesia microtiBabesiosisBorrelia burgdorferiCoinfectionIxodesNew EnglandPeromyscusConceptsB. microtiB. burgdorferiBabesia microtiLyme diseaseRespective causative agentsSpread of babesiosisI. scapularis larvaeInfected micePrimary reservoir hostHigh prevalenceLeucopus miceMiceHuman babesiosisBorrelia burgdorferiLaboratory dataLarval burdenCausative agentMicrotiBurgdorferiCoinfectionReservoir hostsDiseaseR0 modelBasic reproduction numberEnzootic cycleGut Microbiota of the Tick Vector Ixodes scapularis Modulate Colonization of the Lyme Disease Spirochete
Narasimhan S, Rajeevan N, Liu L, Zhao YO, Heisig J, Pan J, Eppler-Epstein R, DePonte K, Fish D, Fikrig E. Gut Microbiota of the Tick Vector Ixodes scapularis Modulate Colonization of the Lyme Disease Spirochete. Cell Host & Microbe 2014, 15: 58-71. PMID: 24439898, PMCID: PMC3905459, DOI: 10.1016/j.chom.2013.12.001.Peer-Reviewed Original ResearchConceptsPeritrophic matrixTranscription factor signal transducerPathogen colonizationLyme disease spirochete Borrelia burgdorferiActivator of transcriptionGut microbiotaArthropod gutsSignal transducerLyme disease spirocheteFunctional linkArthropod vectorsMajor vectorKey glycoproteinsHuman pathogensSpirochete Borrelia burgdorferiGut epitheliumIxodes scapularis ticksColonizationGut epithelial barrierMicrobiotaExpressionGut lumenScapularis ticksBorrelia burgdorferiEpithelial barrier
2012
Identification of Borrelia burgdorferi ospC Genotypes in Host Tissue and Feeding Ticks by Terminal Restriction Fragment Length Polymorphisms
Tsao K, Bent S, Fish D. Identification of Borrelia burgdorferi ospC Genotypes in Host Tissue and Feeding Ticks by Terminal Restriction Fragment Length Polymorphisms. Applied And Environmental Microbiology 2012, 79: 958-964. PMID: 23183976, PMCID: PMC3568573, DOI: 10.1128/aem.03106-12.Peer-Reviewed Original ResearchGeographic Variation in the Relationship between Human Lyme Disease Incidence and Density of Infected Host-Seeking Ixodes scapularis Nymphs in the Eastern United States
Pepin KM, Eisen RJ, Mead PS, Piesman J, Fish D, Hoen AG, Barbour AG, Hamer S, Diuk-Wasser MA. Geographic Variation in the Relationship between Human Lyme Disease Incidence and Density of Infected Host-Seeking Ixodes scapularis Nymphs in the Eastern United States. American Journal Of Tropical Medicine And Hygiene 2012, 86: 1062-1071. PMID: 22665620, PMCID: PMC3366524, DOI: 10.4269/ajtmh.2012.11-0630.Peer-Reviewed Original ResearchHuman Risk of Infection with Borrelia burgdorferi, the Lyme Disease Agent, in Eastern United States
Diuk-Wasser MA, Hoen AG, Cislo P, Brinkerhoff R, Hamer SA, Rowland M, Cortinas R, Vourc'h G, Melton F, Hickling GJ, Tsao JI, Bunikis J, Barbour AG, Kitron U, Piesman J, Fish D. Human Risk of Infection with Borrelia burgdorferi, the Lyme Disease Agent, in Eastern United States. American Journal Of Tropical Medicine And Hygiene 2012, 86: 320-327. PMID: 22302869, PMCID: PMC3269287, DOI: 10.4269/ajtmh.2012.11-0395.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBorrelia burgdorferiEndemic DiseasesHumansIxodesLogistic ModelsLyme DiseaseNymphPrevalenceRisk FactorsTick InfestationsUnited StatesConceptsLyme diseaseHuman riskSpread of infectionHuman infection riskBorrelia burgdorferi sensu strictoRisk factorsBurgdorferi sensu strictoInfection riskTick-borne pathogensLyme disease agentPrevention effortsInfectionBorrelia burgdorferiConfidence intervalsB. burgdorferiInfected nymphsRiskDiseaseRisk focusBurgdorferiUnited StatesDisease agentsHost-seeking nymphsI. scapularis populationsDiagnosisPredicted Outcomes of Vaccinating Wildlife to Reduce Human Risk of Lyme Disease
Tsao K, Fish D, Galvani AP. Predicted Outcomes of Vaccinating Wildlife to Reduce Human Risk of Lyme Disease. Vector-Borne And Zoonotic Diseases 2012, 12: 544-551. PMID: 22251312, DOI: 10.1089/vbz.2011.0731.Peer-Reviewed Original ResearchConceptsMice vaccinationTick biteB. burgdorferi transmissionLyme disease preventionTick blood mealVaccination outcomesHuman riskVaccination effortsDisease preventionLyme diseaseVaccinationInfection prevalenceBorrelia burgdorferiMiceWildlife vaccinationB. burgdorferiCausative agentPredicted outcomeBlood mealVector ticksBiteOutcomesBurgdorferiRiskWildlife reservoirs
2010
Klaus Kurtenbach – a tribute to his life
Margos G, Fish D. Klaus Kurtenbach – a tribute to his life. Ticks And Tick-borne Diseases 2010, 1: 69-72. PMID: 21894640, DOI: 10.1016/j.ttbdis.2009.08.001.Peer-Reviewed Original Research
2009
Phylogeography of Borrelia burgdorferi in the eastern United States reflects multiple independent Lyme disease emergence events
Hoen AG, Margos G, Bent SJ, Diuk-Wasser MA, Barbour A, Kurtenbach K, Fish D. Phylogeography of Borrelia burgdorferi in the eastern United States reflects multiple independent Lyme disease emergence events. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 15013-15018. PMID: 19706476, PMCID: PMC2727481, DOI: 10.1073/pnas.0903810106.Peer-Reviewed Original ResearchMeSH KeywordsAllelesBacterial Typing TechniquesBase SequenceBorrelia burgdorferiDNA, BacterialLyme DiseasePhylogenyUnited StatesConceptsB. burgdorferi populationsPhylogeographic population structurePopulation size expansionBacterial housekeeping geneDisease emergence eventsPopulation structureRange expansionHousekeeping genesB. burgdorferiDescendent clonesEuropean settlementEmergence eventsEastern United StatesSize expansionCoastal ConnecticutTick vectorGeographic extentCommunity-Based Prevention of Lyme Disease and Other Tick-Borne Diseases Through Topical Application of Acaricide to White-Tailed Deer: Background and Rationale
Fish D, Childs JE. Community-Based Prevention of Lyme Disease and Other Tick-Borne Diseases Through Topical Application of Acaricide to White-Tailed Deer: Background and Rationale. Vector-Borne And Zoonotic Diseases 2009, 9: 357-364. PMID: 19650729, DOI: 10.1089/vbz.2009.0022.Peer-Reviewed Original ResearchEffects of Tick Control by Acaricide Self-Treatment of White-Tailed Deer on Host-Seeking Tick Infection Prevalence and Entomologic Risk for Ixodes scapularis-Borne Pathogens
Hoen A, Rollend L, Papero M, Carroll J, Daniels T, Mather T, Schulze T, Stafford K, Fish D. Effects of Tick Control by Acaricide Self-Treatment of White-Tailed Deer on Host-Seeking Tick Infection Prevalence and Entomologic Risk for Ixodes scapularis-Borne Pathogens. Vector-Borne And Zoonotic Diseases 2009, 9: 431-438. PMID: 19650738, DOI: 10.1089/vbz.2008.0155.Peer-Reviewed Original ResearchConceptsEntomologic riskInfection prevalenceB. burgdorferiPrevalence of infectionFever group spirochetesBacterial coinfectionSelf treatmentTick infection prevalenceLyme diseaseBorrelia miyamotoiB. miyamotoiBacterial agentsPrevalenceBorrelia burgdorferiAnaplasma phagocytophilumA. phagocytophilumAdultsRiskBurgdorferiInfectionDiseaseHost-seeking ticksProportion of ticksAdult ticksTick controlClimate and Tick Seasonality Are Predictors of Borrelia burgdorferi Genotype Distribution
Gatewood AG, Liebman KA, Vourc'h G, Bunikis J, Hamer SA, Cortinas R, Melton F, Cislo P, Kitron U, Tsao J, Barbour AG, Fish D, Diuk-Wasser MA. Climate and Tick Seasonality Are Predictors of Borrelia burgdorferi Genotype Distribution. Applied And Environmental Microbiology 2009, 75: 2476-2483. PMID: 19251900, PMCID: PMC2675205, DOI: 10.1128/aem.02633-08.Peer-Reviewed Original Research
2008
MLST of housekeeping genes captures geographic population structure and suggests a European origin of Borrelia burgdorferi
Margos G, Gatewood A, Aanensen D, Hanincová K, Terekhova D, Vollmer S, Cornet M, Piesman J, Donaghy M, Bormane A, Hurn M, Feil E, Fish D, Casjens S, Wormser G, Schwartz I, Kurtenbach K. MLST of housekeeping genes captures geographic population structure and suggests a European origin of Borrelia burgdorferi. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 8730-8735. PMID: 18574151, PMCID: PMC2435589, DOI: 10.1073/pnas.0800323105.Peer-Reviewed Original ResearchConceptsHousekeeping genesIntergenic spacerPopulation structureGeographic population structureChromosomal housekeeping genesMultilocus sequence typing (MLST) schemeB. burgdorferiPhylogenetic signalNorth AmericaEvolutionary relationshipsSequence typing schemeEvolutionary trajectoriesIGS locusSequence dataMLST schemeCultured isolatesGenesBorrelia burgdorferiOuter surface protein CMLST dataDistinct populationsSurface protein CBacterium Borrelia burgdorferiEuropean populationsVector-borne diseases
2007
Fitness Variation of Borrelia burgdorferi Sensu Stricto Strains in Mice
Hanincová K, Ogden NH, Diuk-Wasser M, Pappas CJ, Iyer R, Fish D, Schwartz I, Kurtenbach K. Fitness Variation of Borrelia burgdorferi Sensu Stricto Strains in Mice. Applied And Environmental Microbiology 2007, 74: 153-157. PMID: 17981941, PMCID: PMC2223198, DOI: 10.1128/aem.01567-07.Peer-Reviewed Original ResearchRole of Outer Surface Protein D in the Borrelia burgdorferi Life Cycle
Li X, Neelakanta G, Liu X, Beck DS, Kantor FS, Fish D, Anderson JF, Fikrig E. Role of Outer Surface Protein D in the Borrelia burgdorferi Life Cycle. Infection And Immunity 2007, 75: 4237-4244. PMID: 17620358, PMCID: PMC1951184, DOI: 10.1128/iai.00632-07.Peer-Reviewed Original ResearchConceptsB. burgdorferiSecond blood mealMurine modelSpirochete transmissionB. burgdorferi persistenceLyme borreliosisMiceB. burgdorferi strainsProtein DI. scapularisTick gutBlood mealBurgdorferi strainsSpirochete life cycleBurgdorferiGut extractsIxodes scapularisB. burgdorferi infectivityThreefold decreaseHost-specific signalsScapularisTicksBorreliosisOuter Surface Protein B Is Critical for Borrelia burgdorferi Adherence and Survival within Ixodes Ticks
Neelakanta G, Li X, Pal U, Liu X, Beck DS, DePonte K, Fish D, Kantor FS, Fikrig E. Outer Surface Protein B Is Critical for Borrelia burgdorferi Adherence and Survival within Ixodes Ticks. PLOS Pathogens 2007, 3: e33. PMID: 17352535, PMCID: PMC1817655, DOI: 10.1371/journal.ppat.0030033.Peer-Reviewed Original Research
2006
Fundamental processes in the evolutionary ecology of Lyme borreliosis
Kurtenbach K, Hanincová K, Tsao J, Margos G, Fish D, Ogden N. Fundamental processes in the evolutionary ecology of Lyme borreliosis. Nature Reviews Microbiology 2006, 4: 660-669. PMID: 16894341, DOI: 10.1038/nrmicro1475.Peer-Reviewed Original ResearchConceptsEvolutionary ecologyGenetic changesMultiple-niche polymorphismVector-borne zoonosesB. burgdorferi s.Natural transmission cycleEvolutionary relationshipsEcological parallelsEvolutionary biologyVector-borne pathogensBurgdorferi s.Population fluctuationsProcess-based modelEcologySensu latoDifferent membersFundamental processesVector-borne diseasesPathogensTransmission cycleSpeciesBorrelia burgdorferi sensu latoSame fundamental questionsKey processesBurgdorferi sensu latoMyD88 Deficiency Enhances Acquisition and Transmission of Borrelia burgdorferi by Ixodes scapularis Ticks
Bockenstedt LK, Liu N, Schwartz I, Fish D. MyD88 Deficiency Enhances Acquisition and Transmission of Borrelia burgdorferi by Ixodes scapularis Ticks. Infection And Immunity 2006, 74: 2154-2160. PMID: 16552045, PMCID: PMC1418887, DOI: 10.1128/iai.74.4.2154-2160.2006.Peer-Reviewed Original ResearchConceptsMyD88-/- miceToll-like receptorsWT miceB. burgdorferiB. burgdorferi strainsInnate immune cellsBurgdorferi strainsSkin inoculation siteB. burgdorferi DNAHigh virulence strainDegree of infectivityIxodes scapularis ticksMyD88 deficiencyMolecule MyD88Immune cellsMore spirochetesTransmission of BorreliaEffector functionsHost immunityBorrelia burgdorferi strainsClinical isolatesPathogen burdenMiceBlood meal hostsScapularis ticks