2023
A ticking time bomb hidden in plain sight
Narasimhan S, Fish D, Pedra J, Pal U, Fikrig E. A ticking time bomb hidden in plain sight. Science Translational Medicine 2023, 15: eadi7829. PMID: 37851823, DOI: 10.1126/scitranslmed.adi7829.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2015
Association between body size and reservoir competence of mammals bearing Borrelia burgdorferi at an endemic site in the northeastern United States
Barbour AG, Bunikis J, Fish D, Hanincová K. Association between body size and reservoir competence of mammals bearing Borrelia burgdorferi at an endemic site in the northeastern United States. Parasites & Vectors 2015, 8: 299. PMID: 26024881, PMCID: PMC4459683, DOI: 10.1186/s13071-015-0903-5.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBody SizeBorrelia burgdorferiDisease ReservoirsFemaleHumansIxodesLarvaLyme DiseaseMammalsNew EnglandNymphTick InfestationsConceptsBody sizeLarge-sized mammalsMedium-sized mammalsDifferent mammalian speciesEastern North AmericaSpecies-specific PCRLyme disease agentSmall mammalsMammalian speciesWhite-footed mouseCommon raccoonSized mammalsMammalsBorrelia burgdorferiPine volesBody massGrey squirrelsVirginia opossumReservoir competenceEastern chipmunksIxodes scapularis ticksDisease agentsStriped skunksSpeciesNymphal Ixodes scapularis ticks
2014
Monitoring Human Babesiosis Emergence through Vector Surveillance New England, USA - Volume 20, Number 2—February 2014 - Emerging Infectious Diseases journal - CDC
Diuk-Wasser MA, Liu Y, Steeves TK, Folsom-O'Keefe C, Dardick KR, Lepore T, Bent SJ, Usmani-Brown S, Telford SR, Fish D, Krause PJ. Monitoring Human Babesiosis Emergence through Vector Surveillance New England, USA - Volume 20, Number 2—February 2014 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2014, 20: 225-231. PMID: 24447577, PMCID: PMC3901474, DOI: 10.3201/eid2002.130644.Peer-Reviewed Original ResearchConceptsHuman babesiosisInfectious Diseases journal - CDCProtozoan Babesia microtiDisease-endemic areasTick-borne diseaseBabesiosis-endemic areasSame tick vectorInfection rateInfection ratioTick infection ratesLyme diseaseBabesia microtiHuman casesDiseaseDisease expansionBabesiosisReservoir hostsTick vectorHuman diseasesSurveillanceClose association
2012
Human Risk of Infection with Borrelia burgdorferi, the Lyme Disease Agent, in Eastern United States
Diuk-Wasser MA, Hoen AG, Cislo P, Brinkerhoff R, Hamer SA, Rowland M, Cortinas R, Vourc'h G, Melton F, Hickling GJ, Tsao JI, Bunikis J, Barbour AG, Kitron U, Piesman J, Fish D. Human Risk of Infection with Borrelia burgdorferi, the Lyme Disease Agent, in Eastern United States. American Journal Of Tropical Medicine And Hygiene 2012, 86: 320-327. PMID: 22302869, PMCID: PMC3269287, DOI: 10.4269/ajtmh.2012.11-0395.Peer-Reviewed Original ResearchConceptsLyme diseaseHuman riskSpread of infectionHuman infection riskBorrelia burgdorferi sensu strictoRisk factorsBurgdorferi sensu strictoInfection riskTick-borne pathogensLyme disease agentPrevention effortsInfectionBorrelia burgdorferiConfidence intervalsB. burgdorferiInfected nymphsRiskDiseaseRisk focusBurgdorferiUnited StatesDisease agentsHost-seeking nymphsI. scapularis populationsDiagnosis
2009
Community-Based Prevention of Lyme Disease and Other Tick-Borne Diseases Through Topical Application of Acaricide to White-Tailed Deer: Background and Rationale
Fish D, Childs JE. Community-Based Prevention of Lyme Disease and Other Tick-Borne Diseases Through Topical Application of Acaricide to White-Tailed Deer: Background and Rationale. Vector-Borne And Zoonotic Diseases 2009, 9: 357-364. PMID: 19650729, DOI: 10.1089/vbz.2009.0022.Peer-Reviewed Original ResearchEvaluation of the United States Department of Agriculture Northeast Area-Wide Tick Control Project by Meta-Analysis
Brei B, Brownstein J, George J, Pound J, Miller J, Daniels T, Falco R, Stafford K, Schulze T, Mather T, Carroll J, Fish D. Evaluation of the United States Department of Agriculture Northeast Area-Wide Tick Control Project by Meta-Analysis. Vector-Borne And Zoonotic Diseases 2009, 9: 423-430. PMID: 19650737, PMCID: PMC2904192, DOI: 10.1089/vbz.2008.0150.Peer-Reviewed Original ResearchThe United States Department of Agriculture Northeast Area-Wide Tick Control Project: History and Protocol
Pound J, Miller J, George J, Fish D. The United States Department of Agriculture Northeast Area-Wide Tick Control Project: History and Protocol. Vector-Borne And Zoonotic Diseases 2009, 9: 365-370. PMID: 19650730, DOI: 10.1089/vbz.2008.0182.Peer-Reviewed Original ResearchAcaricidal Treatment of White-Tailed Deer to Control Ixodes scapularis (Acari: Ixodidae) in a New York Lyme Disease-Endemic Community
Daniels T, Falco R, Mchugh E, Vellozzi J, Boccia T, Denicola A, Pound J, Miller J, George J, Fish D. Acaricidal Treatment of White-Tailed Deer to Control Ixodes scapularis (Acari: Ixodidae) in a New York Lyme Disease-Endemic Community. Vector-Borne And Zoonotic Diseases 2009, 9: 381-387. PMID: 19650732, DOI: 10.1089/vbz.2008.0197.Peer-Reviewed Original ResearchThe United States Department of Agriculture's Northeast Area-Wide Tick Control Project: Summary and Conclusions
Pound J, Miller J, George J, Fish D, Carroll J, Schulze T, Daniels T, Falco R, Stafford K, Mather T. The United States Department of Agriculture's Northeast Area-Wide Tick Control Project: Summary and Conclusions. Vector-Borne And Zoonotic Diseases 2009, 9: 439-448. PMID: 19650739, DOI: 10.1089/vbz.2008.0200.Peer-Reviewed Original ResearchConceptsLone star tickFree-living populationsTick-borne diseasePopulation recovery ratesAlternative food resourcesMajor environmental factorsUnited States DepartmentHost-targeted interventionsTick speciesAcorn mastEnvironment-friendly alternativeWhite-tailed deerTicksBait stationsControl projectFood resourcesEastern statesStates DepartmentEffects of Tick Control by Acaricide Self-Treatment of White-Tailed Deer on Host-Seeking Tick Infection Prevalence and Entomologic Risk for Ixodes scapularis-Borne Pathogens
Hoen A, Rollend L, Papero M, Carroll J, Daniels T, Mather T, Schulze T, Stafford K, Fish D. Effects of Tick Control by Acaricide Self-Treatment of White-Tailed Deer on Host-Seeking Tick Infection Prevalence and Entomologic Risk for Ixodes scapularis-Borne Pathogens. Vector-Borne And Zoonotic Diseases 2009, 9: 431-438. PMID: 19650738, DOI: 10.1089/vbz.2008.0155.Peer-Reviewed Original ResearchConceptsEntomologic riskInfection prevalenceB. burgdorferiPrevalence of infectionFever group spirochetesBacterial coinfectionSelf treatmentTick infection prevalenceLyme diseaseBorrelia miyamotoiB. miyamotoiBacterial agentsPrevalenceBorrelia burgdorferiAnaplasma phagocytophilumA. phagocytophilumAdultsRiskBurgdorferiInfectionDiseaseHost-seeking ticksProportion of ticksAdult ticksTick control
2006
An Ixodes scapularis protein required for survival of Anaplasma phagocytophilum in tick salivary glands
Sukumaran B, Narasimhan S, Anderson JF, DePonte K, Marcantonio N, Krishnan MN, Fish D, Telford SR, Kantor FS, Fikrig E. An Ixodes scapularis protein required for survival of Anaplasma phagocytophilum in tick salivary glands. Journal Of Experimental Medicine 2006, 203: 1507-1517. PMID: 16717118, PMCID: PMC2118316, DOI: 10.1084/jem.20060208.Peer-Reviewed Original ResearchConceptsA. phagocytophilum-infected miceRNA interference-mediated silencingA. phagocytophilumTick salivary proteinsI. scapularis salivary glandsRickettsia-like pathogensTick salivary glandsMammalian hostsGenus RickettsiaAnaplasma phagocytophilumGene expressionSalivary glandsIntracellular organismsArthropodsSalivary proteinsPathogensProteinPhagocytophilumExpressionTicksHuman anaplasmosisSilencingGenesOrganismsAnaplasmaMyD88 Deficiency Enhances Acquisition and Transmission of Borrelia burgdorferi by Ixodes scapularis Ticks
Bockenstedt LK, Liu N, Schwartz I, Fish D. MyD88 Deficiency Enhances Acquisition and Transmission of Borrelia burgdorferi by Ixodes scapularis Ticks. Infection And Immunity 2006, 74: 2154-2160. PMID: 16552045, PMCID: PMC1418887, DOI: 10.1128/iai.74.4.2154-2160.2006.Peer-Reviewed Original ResearchConceptsMyD88-/- miceToll-like receptorsWT miceB. burgdorferiB. burgdorferi strainsInnate immune cellsBurgdorferi strainsSkin inoculation siteB. burgdorferi DNAHigh virulence strainDegree of infectivityIxodes scapularis ticksMyD88 deficiencyMolecule MyD88Immune cellsMore spirochetesTransmission of BorreliaEffector functionsHost immunityBorrelia burgdorferi strainsClinical isolatesPathogen burdenMiceBlood meal hostsScapularis ticks
2004
Interaction and Transmission of Two Borrelia burgdorferi Sensu Stricto Strains in a Tick-Rodent Maintenance System
Derdáková M, Dudiòák V, Brei B, Brownstein J, Schwartz I, Fish D. Interaction and Transmission of Two Borrelia burgdorferi Sensu Stricto Strains in a Tick-Rodent Maintenance System. Applied And Environmental Microbiology 2004, 70: 6783-6788. PMID: 15528545, PMCID: PMC525125, DOI: 10.1128/aem.70.11.6783-6788.2004.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArachnid VectorsBorrelia burgdorferiDisease ReservoirsFemaleIxodesLyme DiseasePeromyscusRodent DiseasesTick InfestationsConceptsB. burgdorferi sensu strictoBurgdorferi sensu strictoXenodiagnostic ticksBorrelia burgdorferi sensu strictoUninfected larval ticksGroups of miceWhite-footed miceTransmission cycleControl miceInfected micePrimary infectionExperimental miceI. scapularis ticksLeucopus miceDouble infectionMiceLyme disease agentInfectionScapularis ticksMajor genotypesWeekly intervalsTransmission dynamicsExperimental groupSame strainLarval ticks
2002
Comparison of the Reservoir Competence of Medium-Sized Mammals and Peromyscus leucopus for Anaplasma phagocytophilum in Connecticut
Levin M, Nicholson W, Massung R, Sumner J, Fish D. Comparison of the Reservoir Competence of Medium-Sized Mammals and Peromyscus leucopus for Anaplasma phagocytophilum in Connecticut. Vector-Borne And Zoonotic Diseases 2002, 2: 125-136. PMID: 12737542, DOI: 10.1089/15303660260613693.Peer-Reviewed Original Research
2000
Acquisition of Coinfection and Simultaneous Transmission of Borrelia burgdorferi and Ehrlichia phagocytophila by Ixodes scapularis Ticks
Levin M, Fish D. Acquisition of Coinfection and Simultaneous Transmission of Borrelia burgdorferi and Ehrlichia phagocytophila by Ixodes scapularis Ticks. Infection And Immunity 2000, 68: 2183-2186. PMID: 10722618, PMCID: PMC97402, DOI: 10.1128/iai.68.4.2183-2186.2000.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBorrelia burgdorferi GroupEhrlichiaEhrlichiosisIxodesLyme DiseaseMiceNymphTick InfestationsConceptsHuman granulocytic ehrlichiosisPrior infection statusGranulocytic ehrlichiosisInfected miceLyme diseaseInfection statusI. scapularis nymphsScapularis ticksSecond pathogenSusceptible hostsScapularis nymphsInfected hostIxodes scapularis ticksPrevious infectionI. scapularis ticksEhrlichia phagocytophilaUninfected ticksInfected ticksMiceBorrelia burgdorferiDiseaseEhrlichiosisBorreliaEvidence of interactionNymphal ticks
1998
Estimation of the Incidence of Lyme Disease
Campbell G, Fritz C, Fish D, Nowakowski J, Nadelman R, Wormser G. Estimation of the Incidence of Lyme Disease. American Journal Of Epidemiology 1998, 148: 1018-1026. PMID: 9829875, DOI: 10.1093/oxfordjournals.aje.a009568.Peer-Reviewed Original ResearchPrevention of Borrelia burgdorferi transmission in guinea pigs by tick immunity.
Nazario S, Das S, de Silva AM, Deponte K, Marcantonio N, Anderson JF, Fish D, Fikrig E, Kantor FS. Prevention of Borrelia burgdorferi transmission in guinea pigs by tick immunity. American Journal Of Tropical Medicine And Hygiene 1998, 58: 780-5. PMID: 9660463, DOI: 10.4269/ajtmh.1998.58.780.Peer-Reviewed Original ResearchDensity-dependent factors regulating feeding success of Ixodes scapularis larvae (Acari: Ixodidae).
Levin M, Fish D. Density-dependent factors regulating feeding success of Ixodes scapularis larvae (Acari: Ixodidae). Journal Of Parasitology 1998, 84: 36-43. PMID: 9488335, DOI: 10.2307/3284526.Peer-Reviewed Original ResearchMeSH KeywordsAnesthesiaAnimalsFeeding BehaviorGroomingImmobilizationIxodesLarvaMoltingPeromyscusRabbitsRodent DiseasesTick InfestationsConceptsMice fed 2Larval Ixodes scapularis ticksIxodes scapularis ticksReplete larvaeIxodes scapularis larvaeUnattached ticksFed 2MiceScapularis ticksLarval I. scapularisEngorgement weightSolitary miceDifferent parasitesUnfed ticksTicksContinuous infestationI. scapularisGroupFeeding successTick density
1997
Landscape characterization of peridomestic risk for Lyme disease using satellite imagery.
Dister S, Fish D, Bros S, Frank D, Wood B. Landscape characterization of peridomestic risk for Lyme disease using satellite imagery. American Journal Of Tropical Medicine And Hygiene 1997, 57: 687-92. PMID: 9430528, DOI: 10.4269/ajtmh.1997.57.687.Peer-Reviewed Original ResearchConceptsHigh-risk propertiesGeographic information systemLandsat Thematic Mapper (TM) dataFine-scale differencesLarge geographic areasThematic Mapper dataLandscape compositionLandscape variablesVegetation structureVegetation abundanceLandscape characterizationDisease exposure riskBroadleaf treesOpen lawnSatellite imageryGreater proportionExposure riskCommunityGeographic areasDrag samplingScale differencesWetterSpectral indexInformation systemsIxodes scapularis nymphsFeeding Density Influences Acquisition of Borrelia burgdorferi in Larval Ixodes scapularis (Acari: Ixodidae)
Levin M, Papero M, Fish D. Feeding Density Influences Acquisition of Borrelia burgdorferi in Larval Ixodes scapularis (Acari: Ixodidae). Journal Of Medical Entomology 1997, 34: 569-572. PMID: 9379464, DOI: 10.1093/jmedent/34.5.569.Peer-Reviewed Original ResearchConceptsPrevalence of infectionBorrelia burgdorferi transmissionConsecutive weeksLarval Ixodes scapularisSpirochete prevalenceBorrelia burgdorferiB. burgdorferiLarval I. scapularisInfluences acquisitionPrevalenceBurgdorferiIxodes scapularisWhite-footed mouseIxodes scapularis SayI. scapularisEfficiency of acquisitionI. scapularis populationsInfectionMice