2017
Ticks elicit variable fibrinogenolytic activities upon feeding on hosts with different immune backgrounds
Vora A, Taank V, Dutta SM, Anderson JF, Fish D, Sonenshine DE, Catravas JD, Sultana H, Neelakanta G. Ticks elicit variable fibrinogenolytic activities upon feeding on hosts with different immune backgrounds. Scientific Reports 2017, 7: 44593. PMID: 28300174, PMCID: PMC5353578, DOI: 10.1038/srep44593.Peer-Reviewed Original ResearchConceptsDifferent immune backgroundsImmune backgroundImmunodeficient animalsImmunocompetent animalsAge-matched miceAntibody-blocking assaysIxodes scapularis ticksFibrinogenolytic activityD-dimerAnti-hemostatic factorsImmune defenseTick feedingScapularis ticksReduced levelsBlood feedingEngorgement weightLC-MS/MSFibrinogenolysisNovel roleAnimalsPCR analysisTicksFeeding
2009
Langerhans Cell Deficiency Impairs Ixodes scapularis Suppression of Th1 Responses in Mice
Vesely DL, Fish D, Shlomchik MJ, Kaplan DH, Bockenstedt LK. Langerhans Cell Deficiency Impairs Ixodes scapularis Suppression of Th1 Responses in Mice. Infection And Immunity 2009, 77: 1881-1887. PMID: 19273564, PMCID: PMC2681756, DOI: 10.1128/iai.00030-09.Peer-Reviewed Original ResearchConceptsTh1 responseTick salivaLangerhans cell subsetsLC-deficient miceSkin dendritic cellsTh1 immune responseTh cell polarizationTh cell responsesRegional lymph nodesT cell responsesTick feedingSecondary lymphoid organsGamma interferon productionSpleens of miceWild-type miceIxodes scapularis ticksT helperDendritic cellsLymph nodesLN cellsCell subsetsImmunomodulatory effectsLymphoid organsTh2 cellsImmune response
1996
Suppression of Acute Ixodes scapularis-Induced Borrelia burgdorferi Infection using Tumor Necrosis Factor-α, Interleukin-2, and Interferon-γ
Zeidner N, Dreitz M, Belasco D, Fish D. Suppression of Acute Ixodes scapularis-Induced Borrelia burgdorferi Infection using Tumor Necrosis Factor-α, Interleukin-2, and Interferon-γ. The Journal Of Infectious Diseases 1996, 173: 187-195. PMID: 8537658, DOI: 10.1093/infdis/173.1.187.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAnimalsAntibodies, BacterialArachnid VectorsBlotting, WesternBorrelia burgdorferi GroupDNA, BacterialDrug Therapy, CombinationElectrophoresis, Polyacrylamide GelFluorescent Antibody TechniqueImmune ToleranceImmunity, CellularInjections, IntraperitonealInterferon-gammaInterleukin-2IxodesLyme DiseaseMiceMice, Inbred C3HPolymerase Chain ReactionRandom AllocationTumor Necrosis Factor-alphaConceptsTumor necrosis factorNecrosis factorBurgdorferi infectionB. burgdorferiC3H/HeJ miceTick feedingBorrelia burgdorferi infectionB. burgdorferi infectionImmune containmentPolymerase chain reaction analysisCellular immunityCytokine productionIL-2TNF-alphaHeJ miceInterleukin-2IFN-gammaChain reaction analysisDay 21Infection rateWestern blotEar biopsiesProtection rateInfectionBorrelia burgdorferi