1995
Structural Model of the Phospholamban Ion Channel Complex in Phospholipid Membranes
Arkin I, Rothman M, Ludlam C, Aimoto S, Engelman D, Rothschild K, Smith S. Structural Model of the Phospholamban Ion Channel Complex in Phospholipid Membranes. Journal Of Molecular Biology 1995, 248: 824-834. PMID: 7752243, DOI: 10.1006/jmbi.1995.0263.Peer-Reviewed Original ResearchConceptsSelective ion conductanceTransmembrane domainAmino acid residuesN-terminal 30 amino acid residuesAcid residuesCircular dichroismPentameric protein complexFull-length proteinC-terminal 22 amino acid residuesPhospholipid membranesIon channel complexTransmembrane helicesProtein complexesPhosphorylation sitesMembrane proteinsIon conductanceCarboxy terminusHelix bundleIon poreReticulum membraneInhibitory complexLong helixPentameric complexSecondary structureProtein
1992
Dimerization of Glycophorin a Transmembrane Helices: Mutagenesis and Modeling
Engelman D, Adair B, Brünger A, Flanagan J, Lemmon M, Treutlein H, Zhang J. Dimerization of Glycophorin a Transmembrane Helices: Mutagenesis and Modeling. Jerusalem Symposia 1992, 25: 115-125. DOI: 10.1007/978-94-011-2718-9_11.Peer-Reviewed Original ResearchTransmembrane domainSingle transmembrane domainSite-specific mutagenesisGpA dimerTransmembrane helicesDeletion mutagenesisTransmembrane portionCarboxy terminusDimer interfaceHanded supercoilMutagenesisChimera formLipid bilayersGlycophorin AStaphylococcal nucleaseHuman erythrocyte sialoglycoproteinSDS-PAGEErythrocyte sialoglycoproteinDimerizationClose associationDomainDimersSupercoilsNucleaseTerminus