Synaptic Actin Dysregulation, a Convergent Mechanism of Mental Disorders?
Yan Z, Kim E, Datta D, Lewis D, Soderling S. Synaptic Actin Dysregulation, a Convergent Mechanism of Mental Disorders? Journal Of Neuroscience 2016, 36: 11411-11417. PMID: 27911743, PMCID: PMC5125208, DOI: 10.1523/jneurosci.2360-16.2016.Peer-Reviewed Original ResearchMeSH KeywordsActin CytoskeletonActinsAnimalsBrainDendritic SpinesHumansMental DisordersSynapsesSynaptic TransmissionConceptsMental disordersActivity-dependent modulationCritical neural pathwaysGenetic risk allelesExcitatory synapsesNeurodevelopmental disturbancesNeural pathwaysBrain disordersSynaptic cytoskeletonRisk allelesDisordersNeurodevelopmental disordersActin dysregulationSpine structureConvergent mechanismsAutism spectrum disorderPostsynaptic complexSpectrum disorderPathwayActin cytoskeletonCandidate genesGenetic evidenceActin polymerizationAbnormalitiesSchizophrenia