2016
One-Step Modification of Electrode Surface for Ultrasensitive and Highly Selective Detection of Nucleic Acids with Practical Applications
Li C, Wu D, Hu X, Xiang Y, Shu Y, Li G. One-Step Modification of Electrode Surface for Ultrasensitive and Highly Selective Detection of Nucleic Acids with Practical Applications. Analytical Chemistry 2016, 88: 7583-7590. PMID: 27374134, DOI: 10.1021/acs.analchem.6b01250.Peer-Reviewed Original ResearchConceptsElectrode surfaceCapture probeAccessibility of target moleculesSingle-base discrimination abilityFunctionalized electrode surfaceTarget moleculesUnique probe designSignal probeHairpin DNAProtein repelling abilityComplex samplesRigid scaffoldsDetection of nucleic acidsOne-step modificationBinding modelElectrodeOne-stepAcid sensorsMoleculesNucleic acid sensorsProbe bindingNucleic acidsSurfaceMicro-RNAsPractical applications
1993
The transforming activity of activated Gα12
Jiang H, Wu D, Simon M. The transforming activity of activated Gα12. FEBS Letters 1993, 330: 319-322. PMID: 8397105, DOI: 10.1016/0014-5793(93)80896-3.Peer-Reviewed Original Research
1992
Subunits βγ of heterotrimeric G protein activate β2 isoform of phospholipase C
Katz A, Wu D, Simon M. Subunits βγ of heterotrimeric G protein activate β2 isoform of phospholipase C. Nature 1992, 360: 686-689. PMID: 1465134, DOI: 10.1038/360686a0.Peer-Reviewed Original ResearchConceptsΑ-subunitG proteinsExchange of GDPVitro reconstitution experimentsReceptor-mediated releaseDifferent G proteinsFree GβγPhospholipase C activationGβγ complexG proteins resultsGα subunitsHL-60 cellsGβγ subunitsTransfection assaysPertussis toxinΓ subunitProtein resultsGβγReconstitution experimentsDifferent isoformsSpecific receptorsΒ2 isoformPhospholipase CΒ1 isoformsSubunits