Abstract A040: Intra-epithelia cell dynamics shape evolutionary dynamics and selection of therapy resistant clones in lung cancer
Fu X, Bhargava A, Bailey S, Biswas D, Ruiz C, Kumar S, French P, McGranahan N, Swanton C, Bates P, Sahai E. Abstract A040: Intra-epithelia cell dynamics shape evolutionary dynamics and selection of therapy resistant clones in lung cancer. Cancer Research 2022, 82: a040-a040. DOI: 10.1158/1538-7445.evodyn22-a040.Peer-Reviewed Original ResearchEvolutionary dynamicsResistant clonesEnhanced cell motilityCapability of cancer cellsCell-cell cohesionRNA sequencing dataCell dynamicsExpansion of clonesModel of cell proliferationLung cancer cell linesVariant allele frequencySequence dataNeutral evolutionCell motilityGenomic complexityCancer cell linesCell line modelsAllele frequenciesSelection pressureRandom motilityGrowth arrestMutational processesClonesCell migrationIntra-tumor heterogeneity