2022
Prominent Pseudoacini in Focal Nodular Hyperplasia
Wang D, González IA, Russo PA, Jain D, Zhang X. Prominent Pseudoacini in Focal Nodular Hyperplasia. The American Journal Of Surgical Pathology 2022, 46: 1380-1385. PMID: 35749760, DOI: 10.1097/pas.0000000000001931.Peer-Reviewed Original ResearchConceptsFocal nodular hyperplasiaHepatocellular carcinomaNodular hyperplasiaFNH casesPotential diagnostic pitfallInspissated bileChronic cholestasisInitial biopsyPathologic featuresClinicopathologic correlationDiagnostic challengeNeedle biopsyDifferential diagnosisHepatocellular neoplasmsHepatocellular adenomaDiagnostic pitfallsMorphologic featuresLobular parenchymaStaining patternPseudoaciniBiliary transdifferentiationBiopsyHyperplasiaLesionsHepatocytes
2013
Diagnostic utility and limitations of glutamine synthetase and serum amyloid-associated protein immunohistochemistry in the distinction of focal nodular hyperplasia and inflammatory hepatocellular adenoma
Joseph NM, Ferrell LD, Jain D, Torbenson MS, Wu TT, Yeh MM, Kakar S. Diagnostic utility and limitations of glutamine synthetase and serum amyloid-associated protein immunohistochemistry in the distinction of focal nodular hyperplasia and inflammatory hepatocellular adenoma. Modern Pathology 2013, 27: 62-72. PMID: 23807780, DOI: 10.1038/modpathol.2013.114.Peer-Reviewed Original ResearchMeSH KeywordsAdenoma, Liver CellAdolescentAdultAgedBiomarkers, TumorBiopsyChildChild, PreschoolC-Reactive ProteinDiagnosis, DifferentialDiagnostic ErrorsFemaleFocal Nodular HyperplasiaGlutamate-Ammonia LigaseHumansImmunohistochemistryInflammation MediatorsLiver NeoplasmsMaleMiddle AgedPredictive Value of TestsSerum Amyloid A ProteinYoung AdultConceptsSerum amyloid-associated proteinFocal nodular hyperplasiaAmyloid-associated proteinsInflammatory hepatocellular adenomaNodular hyperplasiaHepatocellular adenomaStaining patternDuctular reactionFibrous stromaFocal nodular hyperplasia casesMap-like patternOverlapping histological featuresGlutamine synthetase stainingHistological featuresProtein immunohistochemistryHyperplasia casesIndeterminate lesionsPositive stainingHyperplasiaDiagnostic utilityAdenomasBlood vesselsFrequent overlapStainingDiagnostic errors
2008
Different cytokeratin and neuronal cell adhesion molecule staining patterns in focal nodular hyperplasia and hepatic adenoma and their significance
Iyer A, Robert ME, Bifulco CB, Salem RR, Jain D. Different cytokeratin and neuronal cell adhesion molecule staining patterns in focal nodular hyperplasia and hepatic adenoma and their significance. Human Pathology 2008, 39: 1370-1377. PMID: 18602664, PMCID: PMC3738023, DOI: 10.1016/j.humpath.2008.01.015.Peer-Reviewed Original ResearchConceptsFocal nodular hyperplasiaNeuronal cell adhesion moleculeHepatic adenomaNodular hyperplasiaCell adhesion moleculeCytokeratin 7Cytokeratin 19Biliary epitheliumProgenitor/stem cellsAdhesion moleculesTelangiectatic focal nodular hyperplasiaCytokeratin 7 stainsStem cellsRare positivityAbnormal perfusionBile ductHepatocellular carcinomaStrong positivityHepatic endotheliumImmunohistochemical analysisModerate stainingFibrous septaDifferent cytokeratinsHyperplasiaAdenomas