Featured Publications
The Association of COVID-19 With Acute Kidney Injury Independent of Severity of Illness: A Multicenter Cohort Study
Moledina DG, Simonov M, Yamamoto Y, Alausa J, Arora T, Biswas A, Cantley LG, Ghazi L, Greenberg JH, Hinchcliff M, Huang C, Mansour SG, Martin M, Peixoto A, Schulz W, Subair L, Testani JM, Ugwuowo U, Young P, Wilson FP. The Association of COVID-19 With Acute Kidney Injury Independent of Severity of Illness: A Multicenter Cohort Study. American Journal Of Kidney Diseases 2021, 77: 490-499.e1. PMID: 33422598, PMCID: PMC7791318, DOI: 10.1053/j.ajkd.2020.12.007.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAgedC-Reactive ProteinCohort StudiesCOVID-19CreatinineDiureticsFemaleHospital MortalityHumansIntensive Care UnitsLength of StayMaleMiddle AgedProportional Hazards ModelsRenal DialysisRenal Insufficiency, ChronicRespiration, ArtificialRisk FactorsSARS-CoV-2Severity of Illness IndexUnited StatesVasoconstrictor AgentsConceptsAcute kidney injurySARS-CoV-2Cohort studyRisk factorsCOVID-19Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testingTime-updated Cox proportional hazards modelsDialysis-requiring acute kidney injuryYale New Haven Health SystemHigher inflammatory marker levelsMore acute kidney injuryCox proportional hazards modelMulticenter cohort studyHigh rateInflammatory marker levelsTraditional risk factorsProportional hazards modelCoronavirus disease 2019KDIGO criteriaNephrotoxin exposureKidney injuryInjury independentUnivariable analysisNasopharyngeal samplesMarker levels
2023
A randomized clinical trial assessing the effect of automated medication-targeted alerts on acute kidney injury outcomes
Wilson F, Yamamoto Y, Martin M, Coronel-Moreno C, Li F, Cheng C, Aklilu A, Ghazi L, Greenberg J, Latham S, Melchinger H, Mansour S, Moledina D, Parikh C, Partridge C, Testani J, Ugwuowo U. A randomized clinical trial assessing the effect of automated medication-targeted alerts on acute kidney injury outcomes. Nature Communications 2023, 14: 2826. PMID: 37198160, PMCID: PMC10192367, DOI: 10.1038/s41467-023-38532-3.Peer-Reviewed Original ResearchConceptsAcute kidney injuryUsual care groupKidney injuryCare groupAcute Kidney Injury OutcomesAlert groupNon-steroidal anti-inflammatory drugsComposite of progressionHours of randomizationMedications of interestAldosterone system inhibitorsClasses of medicationsProton pump inhibitorsRandomized clinical trialsAnti-inflammatory drugsClinical decision support systemNephrotoxic medicationsHospitalized adultsDiscontinuation ratesCertain medicationsPrimary outcomeSubstantial morbiditySystem inhibitorsPump inhibitorsParallel group
2021
Electronic health record alerts for acute kidney injury: multicenter, randomized clinical trial
Wilson FP, Martin M, Yamamoto Y, Partridge C, Moreira E, Arora T, Biswas A, Feldman H, Garg AX, Greenberg JH, Hinchcliff M, Latham S, Li F, Lin H, Mansour SG, Moledina DG, Palevsky PM, Parikh CR, Simonov M, Testani J, Ugwuowo U. Electronic health record alerts for acute kidney injury: multicenter, randomized clinical trial. The BMJ 2021, 372: m4786. PMID: 33461986, PMCID: PMC8034420, DOI: 10.1136/bmj.m4786.Peer-Reviewed Original ResearchConceptsAcute kidney injuryElectronic health record alertsKidney injuryPrimary outcomeMedical recordsYale New Haven Health SystemCare practicesGlobal Outcomes creatinine criteriaLarge tertiary care centerComposite of progressionDays of randomizationReceipt of dialysisPrespecified secondary outcomesTertiary care centerPatients' medical recordsSmall community hospitalNon-teaching hospitalsElectronic health recordsCreatinine criteriaUsual careSecondary outcomesAdult inpatientsKidney diseaseClinical centersWorse outcomes
2016
We Use Dialysate Potassium Levels That Are Too Low in Hemodialysis
Tucker B, Moledina DG. We Use Dialysate Potassium Levels That Are Too Low in Hemodialysis. Seminars In Dialysis 2016, 29: 300-302. PMID: 27061895, DOI: 10.1111/sdi.12495.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSudden cardiac deathCardiac deathDialysate potassium concentrationHigh ultrafiltration ratesShorter dialysis timeDialysis timeHigh riskPredialysis serum potassium concentrationPotassium concentrationSudden cardiac death accountsUltrafiltration rateCalcium concentrationDialysate potassium levelsLow potassium dialysateDiscontinuation of medicationTreatment of constipationSerum potassium concentrationCertain modifiable factorsLow potassiumPredialysis hyperkalemiaCardiovascular eventsHemodialysis patientsRetrospective studyModifiable factorsRisk factors
2015
Pharmacologic Treatment of Common Symptoms in Dialysis Patients: A Narrative Review
Moledina DG, Perry Wilson F. Pharmacologic Treatment of Common Symptoms in Dialysis Patients: A Narrative Review. Seminars In Dialysis 2015, 28: 377-383. PMID: 25913502, DOI: 10.1111/sdi.12378.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsTreatment of fatigueCommon symptomsEnd-stage renal disease patientsRenal disease patientsAnabolic steroid nandroloneDisease-related symptomsEvidence-based guidelinesEfficacy of drugsPharmacologic treatmentDialysis patientsCreatine supplementationDisease patientsTreatment decisionsHemodialysis experienceReduced qualityPatientsNarrative reviewSomatic symptomsSymptomsCrampsESRDTreatmentInsomniaTherapyHeavy burden
2014
Is Low Dialysate Potassium Ever Indicated in Outpatient Hemodialysis?
Moledina D, Geller D. Is Low Dialysate Potassium Ever Indicated in Outpatient Hemodialysis? Seminars In Dialysis 2014, 27: 263-265. PMID: 24635442, DOI: 10.1111/sdi.12212.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2013
Longitudinal Predictors of Uremic Pruritus
Shirazian S, Kline M, Sakhiya V, Schanler M, Moledina D, Patel C, Hazzan A, Fishbane S. Longitudinal Predictors of Uremic Pruritus. Journal Of Renal Nutrition 2013, 23: 428-431. PMID: 24209894, DOI: 10.1053/j.jrn.2013.08.002.Peer-Reviewed Original ResearchConceptsIntact parathyroid hormoneCalcium-phosphate productParathyroid hormoneUremic pruritusSerum calciumSerum phosphateSerum phosphorusElevated serum phosphorusOriginal study groupDisorders of boneHemodialysis patientsPlacebo treatmentPruritus scoreMineral diseaseStudy groupPruritusBone indicatorsSignificant predictorsPatientsMineral statusBoneWeeksLongitudinal predictorsPredictorsCommon problem