2017
Plasma Biomarkers and Kidney Function Decline in Early and Established Diabetic Kidney Disease
Coca SG, Nadkarni GN, Huang Y, Moledina DG, Rao V, Zhang J, Ferket B, Crowley ST, Fried LF, Parikh CR. Plasma Biomarkers and Kidney Function Decline in Early and Established Diabetic Kidney Disease. Journal Of The American Society Of Nephrology 2017, 28: 2786-2793. PMID: 28476763, PMCID: PMC5576932, DOI: 10.1681/asn.2016101101.Peer-Reviewed Original ResearchMeSH KeywordsAgedBiomarkersCase-Control StudiesDiabetes Mellitus, Type 2Diabetic NephropathiesDisease ProgressionFemaleGlomerular Filtration RateHepatitis A Virus Cellular Receptor 1HumansMaleMiddle AgedPredictive Value of TestsPrognosisProspective StudiesRandomized Controlled Trials as TopicReceptors, Tumor Necrosis Factor, Type IReceptors, Tumor Necrosis Factor, Type IIConceptsKidney injury molecule-1Diabetic kidney diseaseTNF receptor 1Progressive diabetic kidney diseaseRenal outcomesTNFR-2Kidney diseaseBaseline levelsAdvanced diabetic kidney diseaseIncident diabetic kidney diseaseKIM-1 levelsKidney function declineInjury molecule-1Prospective cohort studyBaseline plasma samplesBiomarkers of inflammationClinical prognostic modelDiverse pathophysiologic mechanismsType 2 diabetesCase-control studyHigher baseline levelsEGFR declineCohort studyFunction declinePathophysiologic mechanisms
2016
Application of new acute kidney injury biomarkers in human randomized controlled trials
Parikh CR, Moledina DG, Coca SG, Thiessen-Philbrook HR, Garg AX. Application of new acute kidney injury biomarkers in human randomized controlled trials. Kidney International 2016, 89: 1372-1379. PMID: 27165835, PMCID: PMC4869991, DOI: 10.1016/j.kint.2016.02.027.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryBiomarkersCardiopulmonary BypassCreatinineDisease ProgressionHumansInterleukin-18Kidney Function TestsKidney Tubular Necrosis, AcuteLipocalin-2Prospective StudiesRandomized Controlled Trials as TopicRisk FactorsConceptsAcute kidney injuryAKI biomarkersKidney injuryClinical trialsNew biomarkersEarly acute kidney injuryObserved relative risk reductionPostoperative acute kidney injuryAcute kidney injury biomarkersHypothetical trialKidney injury progressionMulti-country trialAcute tubular necrosisCardiopulmonary bypass timeClinical risk factorsKidney injury biomarkersProportion of patientsProspective cohort studyKidney injury markersRelative risk reductionAKI progressionAKI trialsBypass timeCohort studyInjury markers