2020
Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection
Wei J, Alfajaro MM, DeWeirdt PC, Hanna RE, Lu-Culligan WJ, Cai WL, Strine MS, Zhang SM, Graziano VR, Schmitz CO, Chen JS, Mankowski MC, Filler RB, Ravindra NG, Gasque V, de Miguel FJ, Patil A, Chen H, Oguntuyo KY, Abriola L, Surovtseva YV, Orchard RC, Lee B, Lindenbach BD, Politi K, van Dijk D, Kadoch C, Simon MD, Yan Q, Doench JG, Wilen CB. Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection. Cell 2020, 184: 76-91.e13. PMID: 33147444, PMCID: PMC7574718, DOI: 10.1016/j.cell.2020.10.028.Peer-Reviewed Original ResearchMeSH KeywordsAngiotensin-Converting Enzyme 2AnimalsCell LineChlorocebus aethiopsClustered Regularly Interspaced Short Palindromic RepeatsCoronavirusCoronavirus InfectionsCOVID-19Gene Knockout TechniquesGene Regulatory NetworksGenome-Wide Association StudyHEK293 CellsHMGB1 ProteinHost-Pathogen InteractionsHumansSARS-CoV-2Vero CellsVirus InternalizationConceptsSARS-CoV-2 infectionSARS-CoV-2Vesicular stomatitis virusGenome-wide CRISPR screenSWI/SNF chromatinSARS-CoV-2 host factorsAcute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectionTherapeutic targetHost factorsCoronavirus disease 2019 (COVID-19) pathogenesisSyndrome coronavirus 2 infectionCRISPR screensHost genesGene productsMiddle East respiratory syndrome CoVCoronavirus 2 infectionGenetic hitsHuman cellsSARS-CoV-2 spikeNovel therapeutic targetPotential therapeutic targetVero E6 cellsSARS-CoV-1Small molecule antagonists
2010
Identifying potential survival strategies of HIV-1 through virus-host protein interaction networks
van Dijk D, Ertaylan G, Boucher CA, Sloot PM. Identifying potential survival strategies of HIV-1 through virus-host protein interaction networks. BMC Systems Biology 2010, 4: 96. PMID: 20633292, PMCID: PMC2913931, DOI: 10.1186/1752-0509-4-96.Peer-Reviewed Original ResearchMeSH KeywordsDatabases, ProteinFeedback, PhysiologicalHIV InfectionsHIV-1Host-Pathogen InteractionsHumansProtein Interaction MappingProteinsRNA Polymerase IIConceptsProtein interaction networksHuman protein interaction networkHuman proteinsInteraction networksCellular processesRNA polymerase II transcriptionVirus-host protein interaction networksPolymerase II transcriptionHuman Protein Interaction DatabaseSet of proteinsNetwork motifsPotential survival strategiesVirus-host dynamicsProtein interaction databasesCentral human proteinsVirus-host systemsTranscriptional machineryProteasomal proteinsMotif analysisImportant proteinsNetwork motif analysisInteraction databasesViral strategiesProteinSurvival strategies