NEUROIMAGING OF SUBCORTICAL BRAIN VOLUME ALTERATIONS IN PEADIATRIC AND ADULT OBSESSIVE-COMPULSIVE DISORDER: Preliminary findings from the ENIGMA Obsessive-Compulsive Disorder working group
Boedhoe P, Schmaal L, Reddy J, Kwon J, Cheng Y, Nakamae T, Spalletta G, Beucke J, Soriano-Mas C, Lazaro L, Fitzgerald K, Koch K, Hoexter M, Benedetti F, Nakao T, Wang Z, Mataix-Cols D, Simpson H, Walitza S, Tolin D, Arnold P, Huyser C, Denys D, Soreni N, Guner P, Group* E, Thompson P, Hibar D, Jahanshad N, Stein D, van den Heuvel O. NEUROIMAGING OF SUBCORTICAL BRAIN VOLUME ALTERATIONS IN PEADIATRIC AND ADULT OBSESSIVE-COMPULSIVE DISORDER: Preliminary findings from the ENIGMA Obsessive-Compulsive Disorder working group. European Neuropsychopharmacology 2017, 27: 617-619. DOI: 10.1016/j.euroneuro.2016.07.024.Peer-Reviewed Original ResearchBrain volume alterationsPediatric OCD patientsIndividual participant dataThalamus volumeIntracranial volumeOCD patientsDisease durationHippocampal abnormalitiesLateral ventricleSymptom severityVolume alterationsRandom-effects meta-analysis modelRobust imaging markerSeparate stratified analysesLonger disease durationAdult obsessive-compulsive disorderSmaller hippocampal volumesPathophysiology of OCDTotal intracranial volumeAdult OCD patientsMeta-regression analysisMeta-analysis modelPediatric OCD casesSubcortical brain volumesLimited statistical power