2023
An Investigation of the Moderating Role of Estradiol in Interoceptive Exposure Therapy for Women with Panic Disorder.
Levy H, Goldblum R, Mullins J, Tolin D. An Investigation of the Moderating Role of Estradiol in Interoceptive Exposure Therapy for Women with Panic Disorder. Journal Of Cognitive Psychotherapy 2023, 37: 252-265. PMID: 37369539, DOI: 10.1891/jcp-2022-0012.Peer-Reviewed Original ResearchExposure therapyPanic disorderExposure sessionsExposure-based therapySelf-report measuresInteroceptive exposure therapyPanic-related anxietyFear of extinctionCurrent pilot studyAnxious samplesAnxiety sensitivityAnxious womenSubjective distressModerating RoleElectrodermal activityLow estradiolPanic severitySex hormone estradiolExposure outcomesLarge sampleHealthy womenLE groupAnimal modelsSessionsEstradiol
2021
Psychophysiological assessment of stress reactivity and recovery in anxiety disorders
Tolin DF, Lee E, Levy HC, Das A, Mammo L, Katz BW, Diefenbach GJ. Psychophysiological assessment of stress reactivity and recovery in anxiety disorders. Journal Of Anxiety Disorders 2021, 82: 102426. PMID: 34022509, DOI: 10.1016/j.janxdis.2021.102426.Peer-Reviewed Original ResearchConceptsGeneralized anxiety disorderCognitive behavioral therapyAnxiety disordersPanic disorderStressor phaseCBT outcomeHigh-frequency heart rate variabilityFrequency heart rate variabilityPsychophysiological reactivityEnd-tidal CODSM-5 anxiety disordersSpecialty outpatient clinicsHealthy control participantsHeart rate variabilityAdult patientsOutpatient clinicRate recoveryPatientsReactivity phaseResting phaseAnxious patientsAutonomic recoveryRate variabilityControl participantsDiminished changes
2017
A Multisite Benchmarking Trial of Capnometry Guided Respiratory Intervention for Panic Disorder in Naturalistic Treatment Settings
Tolin DF, McGrath PB, Hale LR, Weiner DN, Gueorguieva R. A Multisite Benchmarking Trial of Capnometry Guided Respiratory Intervention for Panic Disorder in Naturalistic Treatment Settings. Applied Psychophysiology And Biofeedback 2017, 42: 51-58. PMID: 28194546, PMCID: PMC5344940, DOI: 10.1007/s10484-017-9354-4.Peer-Reviewed Original ResearchConceptsPanic disorderRespiratory interventionsTreatment settingsTreatment of PDGlobal illness severityTreat response rateNaturalistic treatment settingEnd-tidal CO2Normocapnic rangeRemission rateIllness severityPresent studyClinical resultsFunctional impairmentRepresentative patientsResponse rateClinical settingSimilar outcomesHypocapnic rangeSimilar decreasePanic severityInterventionHome useCliniciansClient adherence
2016
RANDOMIZED TRIAL OF D‐CYCLOSERINE ENHANCEMENT OF COGNITIVE‐BEHAVIORAL THERAPY FOR PANIC DISORDER
Otto MW, Pollack MH, Dowd SM, Hofmann SG, Pearlson G, Szuhany KL, Gueorguieva R, Krystal JH, Simon NM, Tolin DF. RANDOMIZED TRIAL OF D‐CYCLOSERINE ENHANCEMENT OF COGNITIVE‐BEHAVIORAL THERAPY FOR PANIC DISORDER. Depression And Anxiety 2016, 33: 737-745. PMID: 27315514, PMCID: PMC5958622, DOI: 10.1002/da.22531.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyBenzodiazepine usePanic disorderDCS augmentationMulticenter trialD-cycloserineRecent multicenter trialPanic Disorder Severity ScaleExposure-based cognitive-behavioral therapySessions of treatmentStudy pillsPrimary outcomeRandomized trialsBaseline severityPrimary diagnosisAugmentation effectTreatment responseTreatment endpointBooster sessionsSeverity ScaleRole of severityBehavioral therapyDCS efficacyBeneficial effectsPilot study